Lung injury in acute pancreatitis: Mechanisms underlying augmented secondary injury

Elder, Alison S.F.; Saccone, Gino T.P.; Dixon, Dani‐Louise

doi:10.1016/j.pan.2011.12.012

Cited by 63 publications

(37 citation statements)

References 80 publications

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“…Moreover, L-arginine may also stimulate the induction of AP through increased production of cytokines, such as TNF-α and IL-6. Th e important of this model is that it is non-invasive and highly reproducible one (Elder et al 2012). It is not only a good model to study the pathogenic mechanisms of acute necrotizing pancreatitis, but also tremendous to observe and infl uence time line changes of the disease.…”

Section: Discussionmentioning

confidence: 99%

Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats

Aziz

Kamel

Rifaai

2017

Endocrine Regulations

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Objective. Th e aim of the current study was to assess the protective outcome of hemin, a heme oxygenase-1 (HO-1) inducer on L-arginine-induced acute pancreatitis in rats. Acute pancreatitis (AP) is considered to be a critical infl ammatory disorder with a major impact on the patient health. Various theories have been recommended regarding the pathophysiology of AP and associated pulmonary complications.Methods. Twenty-four adult male albino rats were randomly divided into four groups: control group, acute pancreatitis (AP), hemin pre-treated AP group, and hemin post-treated AP group.Results. Administration of hemin before induction of AP signifi cantly attenuated the L-arginine-induced pancreatitis and associated pulmonary complications characterized by the increasing serum levels of amylase, lipase, tumor necrosis factor-α, nitric oxide, and histo-architectural changes in pancreas and lungs as compared to control group. Additionally, pre-treatment with hemin signifi cantly compensated the defi cits in total antioxidant capacities and lowered the elevated malondialdehyde levels observed with AP. On the other hand, post-hemin administration did not show any protection against L-arginine-induced AP.Conclusions. Th e current study indicates that the induction of HO-1 by hemin pre-treatment signifi cantly ameliorated the L-arginine-induced pancreatitis and associated pulmonary complications may be due to its anti-infl ammatory and antioxidant properties.

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Section: Discussionmentioning

confidence: 99%

Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats

Aziz

Kamel

Rifaai

2017

Endocrine Regulations

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“…The ALI and acute respiratory distress syndrome (ARDS) contribute to the majority of AP-associated deaths [9]. Recent research has revealed that alveolar macrophages (AMs) not only serve as phagocytes, but also play an important role as secretory cells to release secretory products such as cytokines, arachidonic acid metabolites and NO in the course of different pulmonary inflammations [10].…”

Section: Discussionmentioning

confidence: 99%

Treatment with ginkgo biloba extract protects rats against acute pancreatitis-associated lung injury by modulating alveolar macrophage

Yang

Bai

et al. 2014

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IntroductionAcute pancreatitis (AP) protease release induces lung parenchymal destruction via inflammatory mediators. Ginkgo biloba has been reported to have anti-inflammatory effects.AimTo evaluate the effect of ginkgo biloba extract on experimental acute pancreatitis-associated lung injury in the rat and to investigate the underlying mechanisms.Material and methodsAcute pancreatitis was induced in rats by injection of 5% sodium taurocholate into the biliary pancreatic duct. Ginkgo biloba extract (GBE) was administered and pancreas and lung injury were assessed by histological examination. Alveolar macrophages were harvested by bronchoalveolar lavage. Specificity fluorescent probe DAF-FM-DA was applied to observe nitric oxide (NO) bioavailability in alveolar macrophage. The expression of tumour necrosis factor α (TNF-α) and macrophage migration inhibitory factor (MIF) protein in alveolar macrophage was studied by ELISA.ResultsIn sodium taurocholate-induced acute pancreatitis, treatment with GBE significantly protected rats against lung injury associated with pancreatitis in histological sections. Ginkgo biloba extract had a tendency to down-regulate NO bioavailability compared with the AP group, but without statistical significance. Moreover, TNF-α and MIF at protein levels in alveolar macrophage with GBE treatment were decreased compared with the AP group.ConclusionsThese results suggest that GBE could effectively protect rats against acute pancreatitis-associated lung injury. The GBE may inhibit excessive activation of alveolar macrophages from acute pancreatitis-associated lung injury through down-regulation of generation of NO, TNF-α and MIF. These findings suggest that ginkgo biloba extract is a suitable candidate as an effective strategy against acute pancreatitis-associated lung injury.

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“…Acute lung injury (ALI) is one of the most common organ failure, approximately 20% patients with acute lung injury develop acute respiratory distress syndrome (ARDS). It is the first cause of patients' death during the early stage (Elder et al 2012). It is believed that the excess production of inflammatory mediators released by macrophages, neutrophils and other cells of the immune system in a cascade network is the underlying mechanism causing ALI in SAP (Shang et al 2009;Zhao et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Downregulation of HMGB1 protects against the development of acute lung injury after severe acute pancreatitis

et al. 2013

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Lung injury in acute pancreatitis: Mechanisms underlying augmented secondary injury

Cited by 63 publications

References 80 publications

Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats

Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats

Treatment with ginkgo biloba extract protects rats against acute pancreatitis-associated lung injury by modulating alveolar macrophage

Downregulation of HMGB1 protects against the development of acute lung injury after severe acute pancreatitis

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