Lung immunity: necessity is the mother of induction

Corbett, Max; Kraehenbuhl, Jean–Pierre

doi:10.1038/nm0904-904

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…The lungs are considered to be immunocompetent organs (Meyer et al, 1998;Moyron-Quiroz et al, 2004;Corbett & Kraehenbuhl, 2004). Thus, in the protection of the lungs from damage and the pathogenesis of many respiratory diseases of major importance is the pulmonary system of mononuclear phagocytes (Brogden et al, 2003;Hiemstra et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Macro and microscopic structure and morphometric indices of the mature horse lungs

Goralskyi,

Sokulskyi,

Hlukhova

et al. 2022

TAVM

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The macro-and microscopic structure of the lungs of mature horses has been studied using anatomical, histological, morphometric and statistical research methods. Morphometric estimation of lung morphological structures is given. The morphofunctional law of continuous unity and interdependence of the morphological structure and function is clearly shown in the system of the respiratory organs. Morphological researches of respiratory organs remain important and actual enough for the determination of their morphofunctional characteristic in different species. They allow diagnosing objectively the state of respiratory organs with the help of markers and criteria of morphological diagnosis. Macro-and micromorphology of lungs in sexually mature horses have characteristic anatomical features which correspond to class, age and species of animals. The presence of individual morphological features in the lung lobule structure is shown. The lung surface lobule pattern, which is formed by the stroma, is prominent in horses and has a smoother pattern compared to other domestic animals. The histological structure of the acini is formed by alveolar passages, alveolar sacs and alveoli. The alveolar tree in horses is of the shortened type, wide and vesicular in shape. Morphometric studies show that the average volume of pulmonary alveoli in clinically healthy horses is 699.8 ± 106.42 thousand µm 3 . The respiratory part of the lungs in horses occupies 54.8 ± 7.4% of the total area of the lung parenchyma, and the connective tissue base occupies 45.2 ± 7.4%.

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Section: Introductionmentioning

confidence: 99%

Macro and microscopic structure and morphometric indices of the mature horse lungs

Goralskyi,

Sokulskyi,

Hlukhova

et al. 2022

TAVM

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“…In contrast, iBALT can limit immunopathology and can contribute to host defense against respiratory pathogens (3,4) via the creation of a local niche to facilitate immune cell crosstalk and accelerated T cell priming (5). Thus, understanding the processes that underlie iBALT formation may offer strategies to limit immunopathology or enhance protective immunity (6,7).…”

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confidence: 99%

Regulatory T Cells Prevent Inducible BALT Formation by Dampening Neutrophilic Inflammation

Foo

Zhang

Lalwani

et al. 2015

The Journal of Immunology

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Inducible BALT (iBALT) can amplify pulmonary or systemic inflammatory responses to the benefit or detriment of the host. We took advantage of the age-dependent formation of iBALT to interrogate the underlying mechanisms that give rise to this ectopic, tertiary lymphoid organ. In this study, we show that the reduced propensity for weanling as compared with neonatal mice to form iBALT in response to acute LPS exposure is associated with greater regulatory T cell expansion in the mediastinal lymph nodes. Ab- or transgene-mediated depletion of regulatory T cells in weanling mice upregulated the expression of IL-17A and CXCL9 in the lungs, induced a tissue neutrophilia, and increased the frequency of iBALT to that observed in neonatal mice. Remarkably, neutrophil depletion in neonatal mice decreased the expression of the B cell active cytokines, a proliferation-inducing ligand and IL-21, and attenuated LPS-induced iBALT formation. Taken together, our data implicate a role for neutrophils in lymphoid neogenesis. Neutrophilic inflammation is a common feature of many autoimmune diseases in which iBALT are present and pathogenic, and hence the targeting of neutrophils or their byproducts may serve to ameliorate detrimental lymphoid neogenesis in a variety of disease contexts.

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Peculiarities of morphoarchitectonics of the lungs of a sexually mature horse (Equus Feruscaballus L., 1758)

Horalskyi

Hlukhova

Sokulskyi

2022

Nauk. vìsn. vet. med.

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The respiratory system is one of the most important systems that carries out the body's gas exchange between air and blood, as a result of which oxygen enters the body and carbon dioxide is removed from it to the environment. In recent years, in the list of diseases of various etiologies, there has been a sharp increase in the number of diseases related to the respiratory organs. There is no doubt that the effective treatment of these pathologies is impossible without knowledge of breed and species characteristics of the anatomy and histology of respiratory organs, the morphofunctional parameters of which should be taken into account when carrying out diagnostic and preventive measures, regarding the prevention of animal diseases, and when providing them with medical care. Therefore, when planning research on the respiratory organs, which include the lungs, one should take into account their topographical-anatomical specific features in domestic animals, their structural-functional features of the microscopic structure, etc. The completed morphological work is a fragment of the research topic of the Department of Normal and Pathological Morphology, Hygiene and Expertise, Polis National University: "Development, morphology and histochemistry of animal organs in normal and pathological conditions", (state registration number – No. 0113V000900). This publication is devoted to the study of the morpho-functional characteristics of the lungs of a sexually mature horse (Equus Feruscaballus L., 1758). Using the method of anatomical dissection, macroscopic, histological, morphometric and statistical methods of research, the macro- and microscopic structure of the lungs was clarified and their belonging to a certain anatomical type was determined. As a result of the conducted studies, the partial structure of the lungs was determined, their topography, shape, dimensions, absolute and relative mass of the lungs were determined, a morphometric assessment of their morphological structures, asymmetry coefficient, etc. was carried out. Staining of tissue sections with hematoxylin and eosin was used to study cell morphology, conduct morphometric studies, and obtain histological examination preparations. When conducting morphological studies, the basic rules of good laboratory practice GLP (1981), the provisions of the "General ethical principles of animal experiments" adopted by the First National Congress of Bioethics (Kyiv, 2001) and the requirements of the "Rules for conducting work using experimental animals", approved by order of the Ministry of Health No. 281 dated November 1, 2000 "On measures to further improve organizational forms of work with the use of experimental animals". It was morphologically investigated that the macro- and micromorphology of the lungs of a sexually mature horse has certain characteristic morphological features, according to the class, age and species of animals. Thus, through scientific studies of the horse, we present the presence of individual morphological features in the lobular structure of the lungs. So, in the left lung of horses there are only two lobes: cranial and caudal, in the right lung there are three lobes: cranial, caudal and additional. Histological structure of acini formed by alveolar ducts, alveolar sacs and alveoli. According to the results of morphological studies, the alveolar tree in horses, represented by a shortened type, is wide and has a bubble shape. Morphometric studies have shown that the average volume of pulmonary alveoli in clinically healthy horses is 699.8±106.42 thousand μm3. The respiratory part of the lungs in horses occupies 54.8±7.4% of the total area of the lung parenchyma, the connective tissue base – 45.2±7.4%. Key words: anatomy, domestic animals, respiratory organs, gas exchange, morphometry, morphotopography, lung lobes, absolute weight, lung histostructure, bronchial tree, respiratory bronchioles, lung asymmetry.

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Lung immunity: necessity is the mother of induction

Cited by 3 publications

References 14 publications

Macro and microscopic structure and morphometric indices of the mature horse lungs

Macro and microscopic structure and morphometric indices of the mature horse lungs

Regulatory T Cells Prevent Inducible BALT Formation by Dampening Neutrophilic Inflammation

Peculiarities of morphoarchitectonics of the lungs of a sexually mature horse (Equus Feruscaballus L., 1758)

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