Lung function in infants with sickle cell disease

Lung Function in Infants with Sickle Cell Anemia

“…Our results showed that obstruction is the main pattern of abnormal lung function in SCA. This finding is in accordance with the 1 previous SCA infant study 9 and with research in the other pediatric age groups. 2 Prospective studies have suggested that the prevalence of restrictive alterations in lung function becomes more common with increasing age.…”

Wheezing and asthma are independent risk factors for increased sickle cell disease morbidity

“…In our cohort, more than half of patients with wheezing did not have physician diagnosis of asthma. This is consistent with prior reports that not all wheezing in SCD patients is due to asthma, and that an asthma‐like syndrome may be a pulmonary manifestation of SCD (high rates of airflow obstruction (Koumbourlis et al , , , , ; Ozbek et al , ) airway hyperreactivity (Field et al , ) and wheezing (Cohen et al , ) in SCD patients with and without asthma) (Anim et al , ; Newaskar et al , ). Our study is one of the first to suggest that this asthma‐like syndrome may also be a risk factor for increased morbidity.…”

Qualidade de sono e função pulmonar em adolescentes portadores de anemia falciforme clinicamente estáveis

“…(28) Whereas adults with SCA present restrictive ventilatory disorder, probably resulting from repeated pulmonary involvement caused by vaso-occlusive pulmonary episodes, (8,29) the child can present conflicting results. (6,7,9) In our study, although most adolescents presented pulmonary function within normal ranges, (30) it was possible to observe increased RV and RV/TLC ratio. In addition, we observed a relationship between being a passive smoker and increased RV.…”