Lung function, transfusion, pulmonary capillary blood volume and sickle cell disease

Lunt, Alan; McGhee, Emily; Robinson, Polly; Rees, David C.; Height, Sue; Greenough, Anne

doi:10.1016/j.resp.2015.11.006

Cited by 23 publications

(9 citation statements)

References 32 publications

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“…In a subsequent study, increased pulmonary capillary blood volume and airways resistance were seen to occur immediately following blood transfusion in children with SCD. Those changes were accompanied by significant reductions in FEV1, VC and FEF25-75 and the change in lung function correlated with the increase in pulmonary capillary blood volume [80]. Those results further support a vascular-airway interaction.…”

Section: A Non-inflammatory Mechanism For Airflow Obstruction: a Vascsupporting

confidence: 61%

Asthma and the outcome of sickle cell disease

Lunt

Sturrock

Greenough

2018

Expert Opinion on Orphan Drugs

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Section: A Non-inflammatory Mechanism For Airflow Obstruction: a Vascsupporting

confidence: 61%

Asthma and the outcome of sickle cell disease

Lunt

Sturrock

Greenough

2018

Expert Opinion on Orphan Drugs

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“…8 The duration of symptoms, smoking history, length of treatment, need for blood transfusion, and respiratory symptoms did not correlate significantly with the spirometry results in patients with VL. Transfusion was associated with alterations in FVC and FEV1, but these changed in the same direction without altering the FVC/FEV1 ratio 17 , which was the main abnormality observed in our patients. Serum albumin level was the only laboratory test that was significantly associated with abnormal spirometry findings.…”

Section: Discussionsupporting

confidence: 48%

Disease Severity Prediction by Spirometry in Adults with Visceral Leishmaniasis from Minas Gerais, Brazil

Maia

Bezerra

Baldi

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Visceral leishmaniasis (VL) is associated with interstitial pneumonitis according to histology and radiology reports. However, studies to address the functional impact on respiratory function in patients are lacking. We assessed pulmonary function using noninvasive spirometry in a cross-sectional study of hospitalized adult VL patients from Minas Gerais, Brazil, without unrelated lung conditions or acute infections. Lung conditions were graded as normal, restrictive, obstructive, or mixed patterns, according to Brazilian consensus standards for spirometry. To control for regional patterns of lung function, we compared spirometry of patients with regional paired controls. Spirometry detected abnormal lung function in most VL patients (70%, 14/20), usually showing a restrictive pattern, in contrast to regional controls and the standards for normal tests. Alterations in spirometry measurements correlated with hypoalbuminemia, the only laboratory value indicative of severity of parasitic disease. Abnormalities did not correlate with unrelated factors such as smoking or occupation. Clinical data including pulmonary symptoms and duration of therapy were also unrelated to abnormal spirometry findings. We conclude that the severity of VL is correlated with a restrictive pattern of lung function according to spirometry, suggesting that there may be interstitial lung involvement in VL. Further studies should address whether spirometry could serve as an index of disease severity in the management of VL.

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“…In the SCD children there was a significant correlation between the pulmonary capillary blood volume and the increased airways airway obstruction [67]. Furthermore, transfusion in SCD children has been shown to acutely increase airway obstruction and this was significantly related to an increase in pulmonary capillary blood volume [68]. Those results suggest that the airway obstruction seen in SCD children, at least in some, relates to their increased pulmonary capillary blood flow rather than bronchial hyper-reactivity.…”

Section: Aetiology Of the Lung Function Abnormalitiesmentioning

confidence: 81%

Pulmonary Complications and Lung Function Abnormalities in Children with Sickle Cell Disease

Greenough¹

2016

Sickle Cell Disease - Pain and Common Chronic Complications

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The pulmonary complications of sickle cell disease (SCD) have a high morbidity and mortality. Fatal pulmonary complications occur in % of adults those with sickle chronic lung disease (SCLD) and pulmonary hypertension have a signiicantly increased mortality. Treatment of SCLD is only supportive. Recurrent acute chest syndrome (ACS) episodes are the major risk factor for SCLD, and ACS is the leading cause of death. Adults with SCD tend to have restrictive lung function abnormalities, whereas, in children, obstructive abnormalities are more frequent. Lung function abnormalities are common even in young children and may relect their chronic anaemia and increased pulmonary capillary blood volume, which increases airway obstruction and may be responsible for their increased wheezing. Whether more aggressive treatment of anaemia would improve lung function and long-term outcomes merits testing. Children with SCD experience a decline in lung function, which is most rapid in younger children in whom ACS episodes are most common highlighting the importance of identifying efective strategies to prevent and optimally treat ACS.

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Lung function, transfusion, pulmonary capillary blood volume and sickle cell disease

Cited by 23 publications

References 32 publications

Asthma and the outcome of sickle cell disease

Asthma and the outcome of sickle cell disease

Disease Severity Prediction by Spirometry in Adults with Visceral Leishmaniasis from Minas Gerais, Brazil

Pulmonary Complications and Lung Function Abnormalities in Children with Sickle Cell Disease

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