Lung function evaluation: comparing fixed percentage reference values vs. the 5th percentile in the diagnosis of airway obstruction

Borrego, Luís Miguel; Couto, Mariana; Almeida, Isabel Tavares de; Pimenta, Lara; Matos, Sara; Morais‐Almeida, Mário

doi:10.5935/2318-5015.20130030

Cited by 1 publication

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“…However, it can increase the rates of false-positive results among older subjects and might not detect the disease in younger subjects (false-negative results). 22 , 23 The increase in the number of false-positive results is minimized when this criterion is based on the fifth percentile or taken as below the LLN. On the other hand, it has already been demonstrated that false-negative results are more common when such a criterion is used.…”

Section: Discussionmentioning

confidence: 99%

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Incidence of chronic obstructive pulmonary disease based on three spirometric diagnostic criteria in Sao Paulo, Brazil: a nine-year follow-up since the PLATINO prevalence study

et al. 2015

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CONTEXT AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a respiratory disease of high prevalence and socioeconomic impact worldwide. It affects approximately 16% of the population of São Paulo. The incidence of COPD is still unknown in Brazil. The aim of this study was to estimate new cases of COPD in a population-based sample in São Paulo, Brazil, using three different spirometric diagnostic criteria, and to assess the concordance between these criteria.DESIGN AND SETTING: Prospective cohort study, in the city of São Paulo, Brazil.METHODS: A questionnaire was applied and anthropometry and pre and post-bronchodilator spirometry were performed on the same subjects as in the initial PLATINO study (2003) in São Paulo. Data from this follow-up study were added to the original database of the initial phase. Incident COPD cases refer to subjects who developed the disease in accordance with each spirometric criterion during the nine-year follow-up period. The Statistical Package for the Social Sciences, version 17.0 (SPSS Inc., Chicago, IL, USA) was used in the analysis and the significance level was set at P < 0.05.RESULTS: 613 subjects participated in the follow-up. New COPD cases ranged in frequency from 1.4% to 4.0%, depending on the diagnostic criterion used. The concordance between the criteria ranged from 35% to 60%.CONCLUSION: The incidence of COPD after a nine-year follow-up was high, but varied according to the spirometric criterion used. The agreement between the criteria for identifying new cases of the disease ranged from 35% to 60%.

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Section: Discussionmentioning

confidence: 99%

“… 25 , 26 , 27 These diagnostic criteria present different sensitivities, specificities and positive and negative predictive values. 23 , 24 , 28 , 29 …”

Section: Discussionmentioning

confidence: 99%