Lung function assessment and its association with blood chromium in a chromate exposed population

Zhang, Yali; Su, Zekang; Hu, Guiping; Hong, Shiyi; Long, Changmao; Zhang, Qiaojian; Zheng, Pai; Wang, Tiancheng; Yu, Shanfa; Yuan, Fang; Zhu, Xiaojun; Jia, Guang

doi:10.1016/j.scitotenv.2021.151741

Cited by 16 publications

(4 citation statements)

References 30 publications

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“…In the pulmonary function tests, FVC measures the total amount of air exhaled and FEV1 refers to the forced expiratory volume in one second. Both FVC and FEV1 can represent the ventilation function and detect the resistance in the airway [24,25]. In our study, the higher FVC and FEV1 measurements in the patients who received hydrogen-oxygen therapy compared to the oxygen therapy alone, suggesting that the former therapy could bene t patients, potentially by decreasing the airway resistance, which is consistent with those previous studies.…”

Section: Discussionsupporting

confidence: 91%

Hydrogen-oxygen therapy improves postoperative pulmonary functions and accelerates recovery through attenuating inflammatory reactions and oxidative stress in patients undergoing lung surgery

Yang

Zhang

et al. 2022

Preprint

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Purpose: To investigate whether hydrogen-oxygen (67%–33%) therapy could improve the postoperative pulmonary function, recovery, complications, inflammatory reactions, and oxidative stress in patients undergoing lung surgery.Methods: We performed a prospective, randomized, single-blind, controlled clinical trial between December 2020 and December 2021. Eligible patients received either a lobectomy or sublobar resection. Postoperatively, they had 2-hour hydrogen-oxygen therapy (group H) or oxygen therapy (group C) daily, for three consecutive days. The pulmonary functions, recovery, pain intensity, oxygen saturation, inflammatory cytokines, and anti-oxidative markers were documented.Results: A total of 66 patients were analyzed, with 33 patients in each group. Both groups had decreased postoperative pulmonary functions, but group H had significantly better postoperative pulmonary functions than group C (forced vital capacities were 1.4±0.5 and 1.0±0.4 L and forced expiratory volumes in the first second were 1.1±0.3 and 0.9±0.3 L in group H and C, respectively (both P<0.01)). Compared to group C, group H had significantly decreased drainage volume, reduced catheter indwelling duration, shortened length of hospital stay, and lower pain intensity. Group H had statistically significantly decreased postoperative serum cytokine TNF-α and IL-6 levels and increased anti-oxidative markers compared to group C. The incidences of postoperative complications were comparable between the two groups. Conclusion: Hydrogen-oxygen therapy could improve postoperative pulmonary functions, decrease pain intensity, accelerate recovery, and shorten the length of the hospital stay in patients who have undergone lung resection, which may be related to its anti-inflammatory and anti-oxidative effects. Trial registration: The Chinese Clinical Trial Registry (registration number ChiCTR2100042101)，the date of registration was January,13,2021.

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Section: Discussionsupporting

confidence: 91%

Hydrogen-oxygen therapy improves postoperative pulmonary functions and accelerates recovery through attenuating inflammatory reactions and oxidative stress in patients undergoing lung surgery

Yang

Zhang

et al. 2022

Preprint

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“…To the best of our knowledge, there is little evidence of the association between welder’s pneumoconiosis risk with concentrations of haemal Cr and Zn, but exposure to Cr and Zn harms lung function. A cohort study on chromate exposed population suggested that short-term high exposure to Cr was associated with obstructive ventilatory impairment, and long-term exposure further led to restrictive ventilatory impairment [ 53 ]. Elevated urinary Zn was associated with lung function reduction, and a dose-dependent association between urinary Zn and restrictive lung disease risk in the general population was previously observed [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Metal Exposure-Related Welder’s Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China

Zhou

Wang

Chen

et al. 2022

IJERPH

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Long-term inhalation of welding fume at high exposure can cause welder’s pneumoconiosis, and metals in welding dust are associated with respiratory dysfunction. This cross-sectional study, which contains 384 Chinese male workers who were or had been working in a container factory, aimed to assess the potential risk of haemal and urinary metal content in welder’s pneumoconiosis. Further, we investigated their effects on lung function parameters. Metal content and lung function were measured using inductively coupled plasma–mass spectrometry (ICP-MS) and spirometer, respectively. The concentration and metal content of respirable dust as well as total dust were collected at this container factory. Lung function of cases with welder’s pneumoconiosis was significantly worse, as indicated by lower values of FVC, FVC% predicted, FEV1, FEV1% predicted, MEF25% predicted, and MMEF% predicted (p < 0.05). Results of logistic regression models showed that haemal Cr and Zn were risk factors of welder’s pneumoconiosis (OR = 4.98, 95%CI: 1.73–21.20, p = 0.009 for Cr; OR = 5.23, 95%CI: 1.56–41.08, p = 0.033 for Zn) after adjusted with age, BMI, working years, welding dust exposure years, and smoking status. Multiple linear regression models showed that several metals (haemal Cd and Pb; urinary Cd and Fe) were significantly associated with different lung function indices in the welder’s pneumoconiosis group. Compared to non-welders, welders were exposed to considerably higher levels of respirable dust, total dust, and six kinds of metals (p < 0.05). In conclusion, haemal Cr and Zn are positively related to welder’s pneumoconiosis. Meanwhile, Cd and Pb might worsen lung function in welder’s pneumoconiosis.

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“…Occupational exposure to Cr VI is a known risk factor for cancer and respiratory disorders. Zhang et al 170 reported on an 8 year longitudinal cohort study investigating the relationship between Cr and lung function in 515 workers from chromate production and application plants in China between 2010 and 2017. Blood Cr levels and lung function were determined by ICP-MS and spirometry, respectively, and exposure–response curves demonstrated a non-linear correlation between lung function and ln-transformed blood Cr.…”

Section: Applications: Clinical and Biological Materialsmentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Patriarca

Barlow

Cross³

et al. 2023

J. Anal. At. Spectrom.

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Lung function assessment and its association with blood chromium in a chromate exposed population

Cited by 16 publications

References 30 publications

Hydrogen-oxygen therapy improves postoperative pulmonary functions and accelerates recovery through attenuating inflammatory reactions and oxidative stress in patients undergoing lung surgery

Hydrogen-oxygen therapy improves postoperative pulmonary functions and accelerates recovery through attenuating inflammatory reactions and oxidative stress in patients undergoing lung surgery

Metal Exposure-Related Welder’s Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

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