Lung distribution, quantification, co-localization and speciation of silver nanoparticles after lung exposure in mice

Smulders, Stijn; Larue, Camille; Sarret, Géraldine; Castillo‐Michel, Hiram; Vanoirbeek, Jeroen; Hoet, Peter

doi:10.1016/j.toxlet.2015.07.001

Cited by 45 publications

(28 citation statements)

References 37 publications

(43 reference statements)

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“…Similar results were obtained also by Jiang and collaborators on Chinese hamster ovary cells [60]. A further confirmation of macrophage role in AgNPs clearance and toxicity was made by Smulders and collaborators [61]. Compared to other works, the authors provided the Ag lung biodistribution and speciation in vivo of different size NPs by means of XRF, XANES, and PIXE techniques combined approach.…”

Section: Speciation Of Metallic Nanoparticlessupporting

confidence: 69%

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Advances in element speciation analysis of biomedical samples using synchrotron-based techniques

Porcaro

Roudeau

Carmona

et al. 2018

TrAC Trends in Analytical Chemistry

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Advances in element speciation analysis of biomedical samples using synchrotron-based techniques. Trends in Analytical Chemistry, Elsevier, 2018, 104, pp. Highlights principle of direct element speciation with synchrotron X-ray absorption spectroscopy (XAS)  experimental modalities for bulk-and micro-XAS speciation and their limitations  review (2012-2017) of XAS in pharmacology, metals and nanoparticles toxicology, physiopathology  future directions and developments of XAS speciation for biomedical research AbstractSynchrotron-radiation X-ray absorption spectroscopy (XAS) is a direct method for speciation analysis with atomic resolution, providing information about the local chemical environment of the probed element. This article gives an overview of the basic principles of XAS and its application to element speciation in biomedical research. The basic principle and experimental modalities of XAS are introduced, followed by a discussion of both its limitations, such as beam damage or detection limits, and practical advices to improve experiments. An updated review of biomedical studies involving XAS published over the last 5 years is then provided, paying special attention to metal-based drug biotransformation, metal and nanoparticle toxicology, and element speciation in cancer, neurological, and general pathophysiology. Finally, trends and future developments such as hyphenated methods, in situ correlative imaging and speciation, in vivo X-ray Absorption Near Edge Spectroscopy (XANES), full-field XANES, and X-ray Free Electron Laser (XFEL) XAS are presented.

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Section: Speciation Of Metallic Nanoparticlessupporting

confidence: 69%

“…The most important data however, came from SXRF analysis and histology comparison: first, a local macrophage increase in the lungs was observed. Second, Ag NPs presence was shown in approximately a quarter of all macrophages in the lumen [61].…”

Section: Speciation Of Metallic Nanoparticlesmentioning

confidence: 98%

Advances in element speciation analysis of biomedical samples using synchrotron-based techniques

Porcaro

Roudeau

Carmona

et al. 2018

TrAC Trends in Analytical Chemistry

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“…Rather, ROS production following minimal cellular insult induces mast cell activation. Silver NPs can either damage cell membranes or enter cells by diffusion for some cell types, including endothelial cells or hepatocytes, and by endocytosis in phagocytic cells . The K + efflux followed by membrane damage may trigger histamine release from mast cells directly or indirectly via the production of intracellular ROS .…”

Section: Resultsmentioning

confidence: 99%

5 nm Silver Nanoparticles Amplify Clinical Features of Atopic Dermatitis in Mice by Activating Mast Cells

Kang

Kim

Lee

et al. 2016

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The triggering effect of silver nanoparticles (NPs) on the induction of allergic reactions is evaluated, by studying the activation of mast cells and the clinical features of atopic dermatitis in a mouse model. Granule release is induced in RBL-2H3 mast cells by 5 nm, but not 100 nm silver NPs. Increases in the levels of reactive oxygen species (hydrogen peroxide and mitochondrial superoxide) and intracellular Ca in mast cells are induced by 5 nm silver NPs. In a mouse model of atopic dermatitis induced by a mite allergen, the skin lesions are more severe and appear earlier in mice treated simultaneously with 5 nm silver NPs and allergen compared with mice treated with allergen alone or 100 nm silver NPs and allergen. The histological findings reveal that number of tryptase-positive mast cells and total IgE levels in the serum increase in mice treated with 5 nm silver NPs and allergen. The results in this study indicate that cotreatment with 5 nm silver NPs stimulates mast cell degranulation and induces earlier and more severe clinical alterations in allergy-prone individuals.

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“…This may result from slowed pulmonary clearance of particles administered by instillation compared to inhalation [45] or the dissolution and formulation of other NP or salt participates [24,36,46] The contribution of silver ions to the observed toxicity observed remains a possible mechanism. It has been reported that 20 nm citrate capped AgNP quickly dissolutes in water however, this dissolution can be slowed in the presence of dipalmitoylphosphatidylcholine a componenet of surfactant [23,47].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Ischemia Reperfusion Injury Following Instillation of 20 nm Citrate-capped Nanosilver

DP¹,

Shannahan²

2015

J Nanomedic Nanotechnol

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Background Silver nanoparticles (AgNP) have garnered much interest due to their antimicrobial properties, becoming one of the most utilized nano-scale materials. However, any potential evocable cardiovascular injury associated with exposure has not been reported to date. We have previously demonstrated expansion of myocardial infarction after intratracheal (IT) instillation of carbon-based nanomaterials. We hypothesized pulmonary exposure to Ag core AgNP induces a measureable increase in circulating cytokines, expansion of cardiac ischemia-reperfusion (I/R) injury and is associated with depressed coronary constrictor and relaxation responses. Secondarily, we addressed the potential contribution of silver ion release on AgNP toxicity. Methods Male Sprague-Dawley rats were exposed to 200 μl of 1 mg/ml of 20 nm citrate-capped Ag core AgNP, 0.01, 0.1, 1 mg/ml Silver Acetate (AgAc), or a citrate vehicle by intratracheal (IT) instillation. One and 7 days following IT instillation the lungs were evaluated for inflammation and the presence of silver; serum was analyzed for concentrations of selected cytokines; cardiac I/R injury and coronary artery reactivity were assessed. Results AgNP instillation resulted in modest pulmonary inflammation with detection of silver in lung tissue and alveolar macrophages, elevation of serum cytokines: G-CSF, MIP-1α, IL-1β, IL-2, IL-6, IL-13, IL-10, IL-18, IL-17α, TNFα, and RANTES, expansion of I/R injury and depression of the coronary vessel reactivity at 1 day post IT compared to vehicle treated rats. Silver within lung tissue was persistent at 7 days post IT instillation and was associated with an elevation in cytokines: IL-2, IL-13, and TNFα and expansion of I/R injury. AgAc resulted in a concentration dependent infarct expansion and depressed vascular reactivity without marked pulmonary inflammation or serum cytokine response. Conclusions Based on these data, IT instillation of AgNP increases circulating levels of several key cytokines, which may contribute to persistent expansion of I/R injury possibly through an impaired vascular responsiveness.

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Lung distribution, quantification, co-localization and speciation of silver nanoparticles after lung exposure in mice

Cited by 45 publications

References 37 publications

Advances in element speciation analysis of biomedical samples using synchrotron-based techniques

Advances in element speciation analysis of biomedical samples using synchrotron-based techniques

5 nm Silver Nanoparticles Amplify Clinical Features of Atopic Dermatitis in Mice by Activating Mast Cells

Cardiac Ischemia Reperfusion Injury Following Instillation of 20 nm Citrate-capped Nanosilver

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