Lung Clear “Sugar” Cell Tumor and Jak V617f Positive Essential Thrombocythemia: A simple Coıncıdence?

Yazak, Volkan; Sargın, Gökhan; Yavaşoğlu, İrfan; Kadıköylü, Gürhan; Tataroğlu, Canten; Bozkurt, Gökay; Bolaman, Zahit

doi:10.4084/mjhid.2013.21

Cited by 3 publications

(4 citation statements)

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“…Between the two genders, there is a slight female preponderance among the CCTL patients. [10,11] Although the age range of the patients have been reported from 8 to 63 years old with the median age of 57 years; the neoplasm seems to present with a higher incidence in the elderly. [12] Usually, the presentation is an asymptomatic patient with an isolated coin lesion, so the lesion often is discovered inadvertently by via radiologic.…”

Section: Discussionmentioning

confidence: 99%

“…Over a long-term observation and research, some unique presentations have been reported in literatures, such as the finding about concurrently with minute pulmonary meningothelial-like nodules in the patient with rectal adenocarcinoma, [13] or concurrently with thrombocytosis (platelet count > 1,000,000/mm³), which was solved after removing the CCTL. [11,14]…”

Section: Discussionmentioning

confidence: 99%

“…Over a longterm observation and research, some unique presentations have been reported in literatures, such as the finding about concurrently with minute pulmonary meningothelial-like nodules in the patient with rectal adenocarcinoma, [13] or concurrently with thrombocytosis (platelet count > 1,000,000/mm³), which was solved after removing the CCTL. [11,14] Radiographically, CCTLs generally present as solitary, round, peripheral and parenchymal nodules with smooth boundary, but without evidence of cavitation or calcification. The location of the tumor has no lobar preference.…”

Section: Discussionmentioning

confidence: 99%

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Clear cell “sugar” tumor of the lung: Diagnostic characteristics of a rare pulmonary tumor: A case report and review of literature

Wang

Zhao

2023

Medicine

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Introduction: Clear cell tumors of the lung (CCTLs), also known as "sugar tumors" for an abundant cellular glycogen concentration, are an extremely rare type pulmonary neoplasm. Often, they are incidentally found on chest roentgenogram or computed tomography scan during routine examination. CCTLs usually present with nonspecific symptoms that pose a diagnostic challenge to clinicians. Accordingly, histopathology remains the gold standard for diagnosing. Moreover, some of them can present with either appearances or histopathological features similar to other pulmonary neoplasms under the light microscope, including pulmonary malignancy, thereby causing misdiagnosis prior to or after surgery. Accordingly, herein, we describe a rare case of CCTL, review the literature has been published, and then discuss the benign versus malignant nature of this rare tumor.Patient concerns: A 59-year-old man presented due to a high-density chest nodule in the left diaphragm. The patient's medical history was unremarkable and he also denied smoking in the past.Diagnosis: Physical examination, there were no noted signs. A new chest contrast-enhanced computed tomography revealed a 3.2 × 2.5 cm, solitary, circular nodule with a smooth edge located in the beside of the left thoracic aorta. Postoperative pathological and immunohistochemical examinations of the surgical specimens revealed a final diagnosis of CCTLs. Interventions:The patient underwent video-assisted thoracoscopic surgery. A wedge resection of left lower lung lobe was carried out and the tumor node was successfully removed alongside normal surrounding parenchyma.Outcomes: The operation was successful. Then the patient recovered completely and continued to do well on postsurgical thoracic surgical clinic visits. The tumor was a benign tumor, and the patient did not require any additional treatment. The patient had been followed-up regularly for 4 years after surgery; she did not experience any complications and remained disease-free. Conclusion:CCTLs should be considered in the differential diagnosis if a patient shows a solitary, circular chest nodule with a smooth edge. They are extremely rare lung tumors that must be differentiated from other lung tumors, especially the malignant tumors. Although pathological and immunohistochemical findings are important for making the diagnosis, the varying histopathological features on microscope make diagnosis difficult. The current case highlights the importance of physicians being aware of and suspecting CCTLs in similar cases, along with knowing the characteristics of CCTLs for the diagnosis and differential diagnosis.Abbreviations: CCTLs = clear cell tumors of the lung, CgA = chromogranin, CT = computed tomography, EMA = epithelial membrane antigen, NSE = neuron-specific enolase, PEC = perivascular epithelial cells, SMA = smooth muscle actin, Syn = synaptophysin, WHO = World Health Organization.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clear cell “sugar” tumor of the lung: Diagnostic characteristics of a rare pulmonary tumor: A case report and review of literature

Wang

Zhao

2023

Medicine

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“…CCTL can present with coughing, shortness of breath or hemoptysis but is most often an incidental finding of a coin lesion or solitary pulmonary nodule on radiographic imaging (8)(9)(10). Some unique presentations found in the literature include thrombocytosis (platelet count >1,000,000/mm 3 ), which resolved after resection of the CCTL (11,12). CCTL has also been found concurrently with minute pulmonary meningothelial-like nodules in the presence of invasive rectal adenocarcinoma (13).…”

Section: Discussionmentioning

confidence: 99%

Clear cell “sugar” tumor of the lung: a case report and review of the literature

2018

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Clear cell "sugar" tumor of the lung is a rare benign tumor that is often an incidental finding during histopathologic workup. It strikingly has a similar resemblance to renal cell carcinoma (RCC) cells. Under the microscope, it is composed of thin cell walls and high levels of glycogen. Therefore, when diagnosed, it is important to rule out metastatic RCC. Here, in this case report, we present a case of clear cell "sugar" tumor of the lung and review the literature that has been published. Clear cell tumor of the lung needs to be studied more extensively as it can present with unique signs and symptoms. It has also occurred in the presence of systemic diseases. This has led researchers to theorize about its etiology which we discuss in this case report.

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Benign Tumors of the Lungs

Akın,

Döngel,

Toker

2023

Airway Diseases

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Lung Clear “Sugar” Cell Tumor and Jak V617f Positive Essential Thrombocythemia: A simple Coıncıdence?

Cited by 3 publications

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Clear cell “sugar” tumor of the lung: Diagnostic characteristics of a rare pulmonary tumor: A case report and review of literature

Clear cell “sugar” tumor of the lung: Diagnostic characteristics of a rare pulmonary tumor: A case report and review of literature

Clear cell “sugar” tumor of the lung: a case report and review of the literature

Benign Tumors of the Lungs

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