Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

“…DCs are critically involved in the pathogenesis of Th2-mediated disorders; however, the exact function of cDC1s in allergic asthma is still debated, as it has been shown that cDC1s can either suppress or induce Th2-mediated inflammation. 11,13,14,16 Our results indicate that TNFAIP3 deletion in Langerin Our observation that mice harboring TNFAIP3-deficient Langerin + cDC1s do not develop Th2-mediated inflammation upon exposure to HDM agrees with other reports that cDC1s suppress Th2-mediated pulmonary inflammation upon helminth infection, 16 ovalbumin sensitization, 10,39 and chronic HDM exposure. 11 Additionally, Helicobacter pylori infection suppresses allergic airway inflammation through activation of cDC1s.…”

Murine Intraepithelial Dendritic Cells Interact With Phagocytic Cells During Aspergillus fumigatus-Induced Inflammation

“…However, no strong correspondence between cDC1/cDC2 and CD103 + CD11b − /CD103 − CD11b + cDC subsets detected by immunohistochemistry was reported. At the same time, a significant reduction of lung CD103 + cDC numbers was detected in Batf3 −/− mice (14). Since cDC1 development was shown to be BATF3-dependent (12), this observation supports the evidence that detected by immunohistochemistry CD103 + CD11b − cells can be classified as cDC1s.…”

Lipopolysaccharide impacts murine CD103+ DC differentiation, altering the lung DC population balance

“…As they are functionally different [13], their simultaneous presence and various complementary functions insure lung homeostasis maintenance by supporting the efficient pulmonary immune response to a variety of stimuli. CD103 + DCs specialize in IL-12 production [14] and cross-presentation of exogenous antigens to CD8 + T cells through MHCI [15], playing an important role in T H 1 immune responses [14,16] and more specifically in anticancer and antiviral immune responses [17,18]. Of note, it was previously reported that gut CD103 + DCs preferentially induce T regulatory cells, although these studies did not clarify whether this specific DC population was considered as DC1 or DC2s [13,19].…”