Lung carcinoma with rhabdoid cells: a clinicopathological study and survival analysis of 14 cases

Shimazaki, Hideyuki; Aida, Shinsuke; Sato, Mitsuhiro; Deguchi, Hirotaka; Osuga, Yutaka; Tamai, Susumu

doi:10.1046/j.1365-2559.2001.01145.x

Cited by 54 publications

(35 citation statements)

References 9 publications

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“…Some well-established neoplasms have variants with rhabdoid features, the so-called composite RTs, for example, rhabdoid meningioma, 37) rhabdoid glioblastoma, 16,28) carcinomas with rhabdoid features, 44) and sarcomas with rhab- doid features. 35) Rhabdoid meningioma corresponds to WHO grade III and shows only focal rhabdoid features.…”

Section: Discussionmentioning

confidence: 99%

Malignant Brain Tumor With Rhabdoid Features in an Adult -Case Report-

Mutou

Hirose

Ikeda

et al. 2011

Neurol. Med. Chir.(Tokyo)

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Rhabdoid tumor (RT) of the central nervous system is an uncommon and aggressive neoplasm that usually affects pediatric patients. Currently, these tumors are classified as malignant RT or atypical teratoid/RT. Another entity of intraparenchymal brain tumor with a rhabdoid component is the extremely rare rhabdoid glioblastoma. A 23-year-old woman presented with a malignant RT in the right thalamus. The tumor was adjacent to the right lateral ventricle and was partially resected. Histological examination revealed prominent proliferation of rhabdoid cells, which is consistent with a diagnosis of malignant RT; the typical features of glioblastoma were not observed. The tumor cells stained positively for integrase interactor-1 and glial fibrillary acidic protein. Therefore, the tumor may have originated from glial components. Genetic analysis using comparative genomic hybridization showed a deoxyribonucleic acid copy-number gain on chromosome 7 but not on chromosome 22. The tumor did not respond to chemotherapy or radiotherapy, and the patient survived for only 4 months after surgery. The present case of malignant RTs shows certain similarities with those of rhabdoid glioblastoma. Further accumulation and analysis of data, including data from genetic analyses, may lead to the identification of a new type of malignant RT.

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Section: Discussionmentioning

confidence: 99%

Malignant Brain Tumor With Rhabdoid Features in an Adult -Case Report-

Mutou

Hirose

Ikeda

et al. 2011

Neurol. Med. Chir.(Tokyo)

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“…However, LC have the tendency to show an epithelial-mesenchymal transition. This is particularly true for LC with a rhabdoid phenotype in which the expression of vimentin was frequently reported (Cavazza et al 1996;Chetty et al 1997;Falconieri et al 2005;Kaneko et al 2002;Shimazaki et al 2001;Tamboli et al 2004;Yilmazbayhan et al 2005). The recognition that undifferentiated lung carcinomas can show a complete loss of cytokeratin expression and their epithelial phenotype during tumor progression resulted in the development of a tumor progression model in which different tumor types are placed according to their mesenchymal phenotype and their malignant potential (Fig.…”

Section: Large Cell Carcinomasmentioning

confidence: 99%

Lung cancer: developments, concepts, and specific aspects of the new WHO classification

Petersen

Warth

2015

J Cancer Res Clin Oncol

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“…The secondary rhabdoid phenotype is most often found in neoplasms of adults and has been encountered in a variety of parent neoplasms, including carcinomas, melanomas, sarcomas, desmoplastic small round cell tumors, neuroblastomas, meningiomas, and gliomas. 7,[25][26][27][28][29][30][31][32][33][34] Occasionally, the parent tumor is not immediately recognizable so that a specific diagnosis is not attainable, beyond that of a highgrade malignant neoplasm. Previously referred to as composite extrarenal rhabdoid tumors, the 'extrarenal' portion is no longer appropriate, given the recent recognition of a rhabdoid variant of renal cell carcinoma.…”

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confidence: 99%

INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas

et al. 2005

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Rhabdoid cells are encountered in specific entities, such as malignant rhabdoid tumor and atypical teratoid/ rhabdoid tumor, as well as in composite rhabdoid tumors derived secondarily from other tumor types. Although rhabdoid tumors are uniformly aggressive, distinction of the entity from the phenotype remains important for its therapeutic implications. The majority of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors affect infants and young children, harbor chromosome 22q deletions, and inactivate the INI1/hSNF5/BAF47 tumor suppressor gene on 22q11.2. In contrast, most composite rhabdoid tumors are diagnosed in adults, with FISH detectable 22q losses the exception rather than the rule. However, this assay remains limited since 22q dosages are maintained in 20-30% of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors. Furthermore, chromosome 22 losses are common in some parent tumor types, particularly meningiomas. The recently developed INI1 antibody shows loss of nuclear expression in malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors, though its status in composite rhabdoid tumors is largely unknown. Therefore, we utilized immunohistochemistry and FISH to study INI1 expression and 22q dosages, respectively, in 40 composite rhabdoid tumors, including 16 meningiomas, 15 carcinomas, three melanomas, two sarcomas, two glioblastomas, and 1 neuroblastoma. Approximately 70% of rhabdoid meningiomas had a 22q deletion, but this was rare in other tumor types. Except for one retroperitoneal leiomyosarcoma, nuclear INI1 expression was retained in all composite rhabdoid tumors, including meningiomas with 22q deletion. Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor. Modern Pathology (2005) 18, 951-958.

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Lung carcinoma with rhabdoid cells: a clinicopathological study and survival analysis of 14 cases

Abstract: Rhabdoid cells are heterogeneous except for epithelial markers and vimentin positivity. Less than 5% of rhabdoid cells has a negligible effect on prognosis.

Cited by 54 publications

References 9 publications

Malignant Brain Tumor With Rhabdoid Features in an Adult -Case Report-

Malignant Brain Tumor With Rhabdoid Features in an Adult -Case Report-

Lung cancer: developments, concepts, and specific aspects of the new WHO classification

INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas

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