Lung carcinoma recognition by blood dielectric spectroscopy

Abstract

Abstract. Lung carcinoma has become one of the malignancies whose morbidity and mortality are growing significantly. Blood is a functional body fluid, it delivers oxygen and nutrients to the other parts of the body, and it is a pathway of tumor metastasis. This paper studies the possibility of diagnosing lung carcinoma by blood dielectric spectroscopy. Comparison experiments were carried out to trace the dielectric spectroscopy of blood with and without lung carcinoma changing at different tumor stages from 100 Hz to 100 MHz. The research results show that the discrepancy of complex permittivity between rat blood with and without lung carcinoma becomes significant with tumor growing, which is worthy for clinical diagnosis.

Quick, Single-Frequency Dielectric Characterization of Blood Samples of Pediatric Cancer Patients by a Cylindrical Capacitor: Pilot Study

“…The results of this work are consistent with the evidence presented in the literature in that the electrical properties of normal tissues differ from those of cancerous ones. As mentioned before, other macroscopic approaches have been reported for the detection of cancer in adult patients, with similar findings [29][30][31][32].…”

“…Studies with a similar idea have been done in recent years for adult patients with lung and breast cancer [29][30][31][32]. The idea presented in this work has several novelties and advantages over the previous ones: (1) it focuses on hematologic cancers (not reported before) in children; (2) it macroscopically measures whole blood (not blood components) at low frequencies (which enables the development of inexpensive systems); and (3) it offers a simple, self-made device (a cylindrical capacitor) to carry out the measurements.…”

Thermodynamics Characterization of Lung Carcinoma, Entropic Study and Metabolic Correlations

“…In particular, the values of a (00) and a (11) increased up to a maximum of around 10 5 Hz and then decreased, keeping constant for ω > 10 6 Hz. Here, too, the relationships (8) and 9are valid. Figure 7 shows a greater production of entropy in healthy than in cancerous cells.…”

“…This is due to both the indistinguishable characteristics of the first cancer cells, as well as the difficulty in coordinating non-invasive and low costs screening with diagnostic sensitivity. In recent years there has been a rising interest in dielectric spectroscopy, an investigation technique that can obtain information on the chemical-physical characteristics of biological materials starting from the dielectric properties [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. The response of biological tissues to an electric field is characterized by two intrinsic properties conductivity and relative permittivity, which are both dependent on frequency.…”