Quick, Single-Frequency Dielectric Characterization of Blood Samples of Pediatric Cancer Patients by a Cylindrical Capacitor: Pilot Study

Abstract

In this paper, as an application in biometrics, the electrical capacitance of normal and cancerous blood samples is experimentally determined in order to test the null hypothesis that the electrical capacitance of the two samples differs. The samples taken from healthy donors and patients diagnosed with different types of hematologic cancer are examined by a cylindrical capacitor with blood as its dielectric. The capacitance of these samples is measured at room temperature and a single frequency of 120 Hz, well below the frequency where β -dispersion starts, using a simple LCR meter device. The measurements indicate that the capacitance of the blood increases under applied electric field for a short period of time and asymptotically reaches its steady-state value. The measured values for the healthy group agreed with previous data in the literature. By the use of the unpaired two-tailed T-test, it is found that cancerous blood has higher values of capacitance when compared to normal samples ( p < 0.05 ). The reasons that might lead to such alterations are discussed from a biological perspective. Moreover, based on correlation calculations, a strong negative association is observed between blood capacitance and red blood cell (RBC) count in each group. Furthermore, sensitivity (SE) and specificity (SP) analysis demonstrates that for a threshold value between 15 and 17 for the capacitance value, both SE and SP are 100%. These preliminary findings on capacitance values may pave the way for the development of inexpensive and easy-to-use diagnosis tools for hematologic cancers at medical facilities and for in-home use, especially for children.

Sensitivity Improvement of Surface Plasmon Resonance Biosensors with GeS-Metal Layers

“…This is the surface plasmon resonance (SPR) phenomenon [4], and this kind of phenomenon can be used for real-time monitoring and label-free sensing [5]. Biochemical sensors based on SPR technology have many advantageous properties, such as high operation sensitivities, detection accuracy, and biocompatibilities [6][7][8]. These kinds of sensors have been studied and used for many biological and chemical applications [9], such as medical diagnosis, enzyme detection, and pharmaceuticals [10].…”