Lung Carcinoma in the Era of Personalized Medicine: The Role of Cytology

Zakowski, Maureen F.; Bibbo, Marluce

doi:10.1159/000345183

Cited by 4 publications

(2 citation statements)

References 42 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although recent randomized studies failed to detect a significant improvement in the diagnostic yield of transbronchial aspiration techniques with the addition of ROSE [21] , this has been shown to reduce the number of needle passes, the complications rate, and the need for additional procedures by increasing the success rate of molecular genotyping [22] . In the era of targeted lung cancer therapy, indeed, a sample should be considered as diagnostic only if it provides an amount of cells suitable for both tumor subtyping and molecular genotyping [23] . Of note, in the present study, a complete molecular characterization was, in fact, obtained in more than 95% of patients with NSCLC, regardless of the technique employed.…”

Section: Discussionmentioning

confidence: 99%

Conventional versus Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymph Adenopathies: A Randomized Controlled Trial

et al. 2017

View full text Add to dashboard Cite

Background: Conventional transbronchial needle aspiration (c-TBNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are both valuable diagnostic techniques for the diagnosis of hilar/mediastinal lesions. Although a superiority of EBUS-TBNA over c-TBNA may be expected, evidence-based data on a direct comparison between these 2 procedures are still lacking. Objectives: We aimed to test the superiority of EBUS-TBNA over c-TBNA in a randomized trial and to evaluate the cost-effectiveness profile of a staged strategy, including c-TBNA as initial test followed by EBUS-TBNA, in case of inconclusive results at rapid on-site evaluation. Methods: Eligible patients were randomized 1:1 to either the EBUS-TBNA or c-TBNA group. The primary endpoint was to test the superiority of EBUS-TBNA sensitivity over c-TBNA. The secondary endpoints included the sensitivity of the staged strategy, as well as costs and safety related to each procedure and to their sequential combination. Results: A total of 253 patients were randomized to either EBUS-TBNA (n = 127) or c-TBNA (n = 126), and 31 patients of the c-TBNA group subsequently underwent EBUS-TBNA. The sensitivity of EBUS-TBNA was higher, but not significantly superior to that of c-TBNA (respectively. 92% [95% CI 87-97] and 82% [95% CI 75-90], p > 0.05). The sensitivity of the staged strategy was 94% (95% CI 89-98). No major adverse events occurred. Conclusions: EBUS-TBNA was the single best diagnostic tool, although not significantly superior to c-TBNA. Due to the favorable cost-effectiveness profile of their sequential combination, in selected scenarios with a high probability of success from the standard procedure, these should not be necessarily intended as competitive and the staged strategy could be considered in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Conventional versus Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymph Adenopathies: A Randomized Controlled Trial

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The main challenge to a cytopathologist in the present era of personalized treatment is to be able to devise techniques that can provide more information with less tissue available. [ 17 ] We can differentiate between small-cell carcinoma and NSCLC in over 90% cases by FNAC. In 10-40% of NSCLC cases, it may not be possible to subtype NSCLC based on morphology alone that applies for both small biopsies as well as cytology samples.…”

Section: Necessity To Subclassify Nsclcmentioning

confidence: 99%

Role of FNAC, fluid specimens, and cell blocks for cytological diagnosis of lung cancer in the present era

Gupta

Sekar

Rajwanshi

2015

J Cytol

View full text Add to dashboard Cite

Cytoblocks prepared from residual tissue fluids and fine-needle aspirations can be useful adjuncts to smears for establishing a more definitive cytopathologic diagnosis. These paraffin embedded cytoblocks have been popular since these can be handled like any other histologic specimen. Rapid on-site evaluation (ROSE) can help in attaining adequate material in the cytoblock, which is a major concern to the cytopathologists. Ancillary studies can be done using cytoblocks including IHC and various molecular techniques. The opportunities for cytopathologists to influence therapy, and uncover strategies in the complex field of lung cancer are exciting and limitless especially in the presence of an adequate cytoblock

show abstract

The Role of the Pulmonologist in Rapid On-site Cytologic Evaluation of Transbronchial Needle Aspiration

Bonifazi

Sediari

Ferretti

et al. 2014

Chest

View full text Add to dashboard Cite

Lung Carcinoma in the Era of Personalized Medicine: The Role of Cytology

Cited by 4 publications

References 42 publications

Conventional versus Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymph Adenopathies: A Randomized Controlled Trial

Conventional versus Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymph Adenopathies: A Randomized Controlled Trial

Role of FNAC, fluid specimens, and cell blocks for cytological diagnosis of lung cancer in the present era

The Role of the Pulmonologist in Rapid On-site Cytologic Evaluation of Transbronchial Needle Aspiration

Contact Info

Product

Resources

About