Lung cancer prognosis in Spain: The role of histology, age and sex

Salmerón, Diego; Chirlaque, María‐Dolores; Izarzugaza, M. Isabel; Sánchez, María‐José; Marcos‐Gragera, Rafael; Ardanáz, Eva; Galcerán, Jaume; Mateos, Antonio Navareño; Navarro, Carmen

doi:10.1016/j.rmed.2012.06.006

Cited by 50 publications

(25 citation statements)

References 26 publications

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“…1 In Spain, as in the rest of the developed world, certain changes are taking place, such as a greater incidence of LC in women, though the poor prognosis remains. 2 Among HIV-infected persons, LC is the third most common malignancy, preceded only by Kaposi's sarcoma and non-Hodgkin lymphoma. [3][4][5][6] Moreover, epidemiologic data suggest that the risk of LC is two to four times greater in HIV-infected persons than in the general population, even after adjusting for other factors such as smoking intensity and duration.…”

Section: Introductionmentioning

confidence: 99%

Lung cancer in HIV-infected patients

et al. 2013

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PurposeSeveral studies have shown that HIV patients are at higher risk of lung cancer. Our aim is to analyse the prevalence and features of lung cancer in HIV-infected patients. MethodsThe clinical charts of 4,721 HIV-infected patients seen in three hospitals of southeast Spain (study period 1992Á2012) were reviewed, and all patients with a lung cancer were analysed. ResultsThere were 61 lung cancers, giving a prevalence of 1.2%. There was a predominance of men (82.0%), and smokers (96.6%; mean pack-years 35.2), with a median age of 48.0 (41.7Á52.9) years, and their distribution according to risk group for HIV was: intravenous drug use 58.3%, homosexual 20.0%, and heterosexual 16.7%. Thirty-four (56.7%) patients were Aids cases, and 29 (47.5%) had prior pulmonar events: tuberculosis 16, bacterial pneumonia 9, and P. jiroveci pneumonia 4. The median nadir CD4 count was 149/mm 3 (42Á232), the median CD4 count at the time of diagnosis of the lung cancer was 237/mm 3 (85Á397), and 66.1%B350/mm 3 . 66.7% were on ART, and 70% of them had undetectable HIV viral load. The most common histological types of lung cancer were adenocarcinoma and epidermoid, with 24 (40.0%) and 23 (38.3%) cases, respectively. There were 49 (80.3%) cases with advanced stages (III and IV) at diagnosis. The distribution of treatments was: only palliative 23 (39.7%), chemotherapy 14 (24.1%), surgery and chemotherapy 8 (13.8%), radiotherapy 7 (12.1%), surgery 4 (6.9%), and other combined treatments 2 (3.4%). Forty-six (76.7%) patients died, with a median survival time of 3 months. The Kaplan-Meier survival rate at 6 months was 42.7% (at 12 months 28.5%). ConclusionsThe prevalence of lung cancer in this cohort of HIV-patients is high. People affected are mainly men, smokers, with transmission of HIV by intravenous drug use, and around half of them with prior opportunistic pulmonary events. Most patients had low nadir CD4 count, and were immunosuppressed at the time of diagnosis. Adenocarcinoma is the most frequent histological type. The diagnosis is usually made at advanced stages of the neoplasm, and mortality is high.

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Section: Introductionmentioning

confidence: 99%

Lung cancer in HIV-infected patients

et al. 2013

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“…[17][18][19][20] The current male-to-female ratio in the USA is close to one. [21,22] Our ratio of males to females with lung cancer is still high, [23][24][25] similar to other spainish rural areas. In any case, the male-to-female ratio is still substantially higher in Spain (8.5 in 2003) [26,27] than in other Western countries, where it varies between 1.3 and 4.5 likely due to the much more rare habit of smoking in women than in men.…”

Section: Discussionmentioning

confidence: 69%

“…25.5 months(22)(23)(24)(25)(26)(27)(28)(29) [Figure 4]. At last follow-up, 22.4% of patients were alive and 77.6% were deceased.…”

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confidence: 99%

Ten years of lung cancer in a single center: gender, histology, stage and survival

Gironés¹,

López²,

Chulvi³

et al. 2015

J Cancer Metastasis Treat

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The aim was to describe, in a prospective manner, the clinical, histopathological and epidemiological characteristics of lung cancer patients who attended as outpatients at the Lluís Alcanyís, Xàtiva Medical Oncology Hospital, València, Spain from January 2004 to July 2014. We also analyzed survival and compared our data with that reported in the literature. Methods: Clinical and demographic characteristics were analyzed for the entire series and trends were compared by year of diagnosis. Changes in epidemiology were examined and compared. Results: There were 701 patients (91.4% were men, mean age 67.6). Main histology was squamous cell carcinoma (41.5%). Squamous cell carcinoma prevailed in men (45.5%) and adenocarcinoma (ADC) in women (60.3%). The percentage of men with lung cancer and of patients with squamous cell carcinoma was higher than in the reported worldwide data and remained throughout the 10 years period. Mean survival was low, with < 10% survivors at 5 years. Stage of disease remained the main prognostic factor for survival. Conclusion: Squamous cell carcinoma continues to be the most frequent histological type in our area. Male and smoking is associated with lung carcinoma while ADC more often occurs in females. Over the time, our epidemiological and histological patterns have not changed, possibly in relation to maintenance of smoking habits.

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“…Una serie de estudios indican que la supervivencia del cáncer de pulmón es mejor en mujeres que en hombres, independientemente del estadio, la histología, o el tratamiento (Fu et al, 2005;Janjigian et al, 2010;Micheli et al, 2009;Nakamura et al, 2011;Ries et al, 2007;Sagerup, Smastuen y Johannesen, 2001;Salmeron et al, 2012;Wakelee et al, 2012;WheatleyPrice et al, 2010). Según los datos de la SEER, la su-a235 pervivencia relativa a 5 años para mujeres con cáncer de pulmón es del 18,2% comparada con el 14,5% en hombres.…”

Section: Pronóstico Del Cáncer De Pulmón En Mujeresunclassified

El cáncer de pulmón en mujeres

Felip

2015

Arbor

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Hospital Universitari Vall d'Hebronefelip@vhebron.net RESUMEN: El cáncer de pulmón es la enfermedad maligna más frecuente en el mundo. En los últimos diez años en España, la mortalidad por cáncer de pulmón ha aumentado un 20% en las mujeres frente a un 5% en los hombres, debido a los cambios recientes de patrones de hábito tabáquico entre ambos sexos. El tabaco sigue siendo la causa única más importante de una enfermedad prevenible en un alto porcentaje de casos. Es muy importante que la población conozca esta realidad y que modifique el estilo de vida, eliminado el tabaquismo, para poder detener esta epidemia que representa el cáncer de pulmón. En este artículo se revisarán aspectos epidemiológicos, así como factores de riesgo, características y pronóstico de las mujeres con cáncer de pulmón, con una especial atención a la población española. PALABRAS CLAVE: adenocarcinoma; EGFR; tabaco.ABSTRACT: Lung cancer is the most frequent malignant disease in the world. Over the last ten years lung cancer mortality has risen in Spain by 20% among women compared with 5% among men. This is due to recent changes in both genders' smoking habits. Tobacco is still the single most important cause of a preventable disease in a high percentage of cases. It is extremely important that the population is aware of this and that people modify their lifestyle accordingly, giving up smoking in order to halt the lung cancer epidemic. In this article, we review epidemiological aspects, as well as risk factors, characteristics and the prognosis for women with lung cancer, focusing particularly on the Spanish population.

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Lung cancer prognosis in Spain: The role of histology, age and sex

Cited by 50 publications

References 26 publications

Lung cancer in HIV-infected patients

Lung cancer in HIV-infected patients

Ten years of lung cancer in a single center: gender, histology, stage and survival

El cáncer de pulmón en mujeres

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