Lung cancer presenting with trigeminal neuropathy

Cerase, Alfonso; Brindisi, Leopoldo; Lazzeretti, Luigi; Pepponi, Emanuela; Venturi, Carlo

doi:10.1007/s10072-011-0577-5

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…A common finding in this pathology is enlargement of the ganglion with splaying of the nerve fibers. Metastasis of pulmonary adenocarcinoma to the DRG has not previously been described but cases of trigeminal ganglion metastasis have [4]. Our case report provides further information on the potential of this entity to spread to the border between the central and peripheral nerve systems.…”

Section: Discussionmentioning

confidence: 58%

Pulmonary adenocarcinoma metastasis to a dorsal root ganglion: a case report and review of the literature

et al. 2013

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IntroductionThe dorsal root ganglion is a rare manifestation of metastatic spread. We report what we believe to be the first case of metastasis of a pulmonary adenocarcinoma to the lumbar dorsal root ganglion. Only four descriptions for different primary tumors spreading to the dorsal root ganglion have been described in the literature so far.Case presentationA 70-year-old Caucasian woman with a four-month history of left-sided lumbar radiculopathy was admitted to our department under the assumption of a herniated lumbar disc. Her past medical history included a pulmonary adenocarcinoma and invasive ductal breast cancer.Lumbar magnetic resonance imaging revealed a space-occupying mass in her left neuroforamen L3-L4 with compression of her L3 nerve root. Neurinoma was taken into account as a differential diagnosis, although not considered typical. Surgery revealed a metastasis of pulmonary adenocarcinoma to her dorsal root ganglion.ConclusionsDorsal root ganglion metastases seem to be extremely rare and can mimic primary local nerve sheath tumors. Therefore, they usually present as incidental findings. Resection should be performed strictly under intraoperative monitoring as tumor spread between the nerve fibers is commonly observed. Metastases should be taken into account in spinal nerve tumors involving the dorsal root ganglion, especially in patients harboring known malignant diseases. The low incidence means that no clear treatment advice can be given. Resection is possible under intraoperative monitoring and relieves neurological symptoms.

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Section: Discussionmentioning

confidence: 58%

Pulmonary adenocarcinoma metastasis to a dorsal root ganglion: a case report and review of the literature

et al. 2013

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“…Eight (75%) of the 12 patients showed symptoms relating to sphenoid bone metastasis as an initial presentation of the lung carcinoma. Only one report described trigeminal neuropathy caused by metastasis to Meckel's cave, site of the ganglion of the trigeminal nerve, resulting in the symptoms seen as the first presentation of lung adenocarcinoma [8]. The reason our patient did not complain of any respiratory symptoms, back pain, or general symptom remains unclear.…”

Section: Discussionmentioning

confidence: 86%

“…Characteristics of 12 patients with metastasis of lung carcinoma to the sphenoid bone identified from the literature published since 1990 are summarized in the Table 1 [4, 5, 6, 7, 8, 9, 10, 11]. Median age of the patients was 63 years (range, 47–76 years).…”

Section: Discussionmentioning

confidence: 99%

Lung Adenocarcinoma with Cheek Dysesthesia as an Initial Symptom: A Case Report and Literature Review

et al. 2019

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Metastasis from lung carcinoma to the sphenoid bone is rare. Patients with symptoms related to sphenoid bone metastasis as the initial presentation of carcinoma are thus also rare. Herein, we report the case of a patient presenting with only cheek dysesthesia as the first sign of lung adenocarcinoma. The 74-year-old woman presented with a 2-month history of left cheek dysesthesia. CT showed a tumor around 2.5 cm in diameter with heterogeneous enhancement of the central focus at the left foramen rotundum in the sphenoid bone. We endoscopically biopsied the tumor through the left sphenoid sinus. Results of histologic examination were consistent with lung adenocarcinoma. FDG-PET/CT analysis demonstrated lung carcinoma that had already metastasized to mediastinal lymph nodes and multiple bones, such as the ribs and lumbar vertebras, in addition to the sphenoid bone. As EGFR gene mutation (p.L858R) was identified, the patient was treated with oral gefinitib. This treatment proved quite effective, and the patient remains alive without tumor growth as of 18 months.

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“…Only a handful of cases have ever been reported in the literature with primary malignancy sites including breast, colon, kidney, prostate, lymphocytic, thyroid, esophagus, cervix, and endometrium. ( Hooker et al, 2018 , Soni, 2010 , Reshko, 2018 , Cerase, 2011 , Wang et al, 2016 , Sudha et al, 2019 ). Here we describe a report of a young woman with metastatic EOC to the femur, vertebrae, and Meckel’s cave with leptomeningeal spread, all found around the time of initial diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Metastatic epithelial ovarian cancer to Meckel’s cave with leptomeningeal spread at time of diagnosis

Kahn

Gandhi

Mvula

et al. 2020

Gynecologic Oncology Reports

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Lung cancer presenting with trigeminal neuropathy

Cited by 7 publications

References 11 publications

Pulmonary adenocarcinoma metastasis to a dorsal root ganglion: a case report and review of the literature

Pulmonary adenocarcinoma metastasis to a dorsal root ganglion: a case report and review of the literature

Lung Adenocarcinoma with Cheek Dysesthesia as an Initial Symptom: A Case Report and Literature Review

Metastatic epithelial ovarian cancer to Meckel’s cave with leptomeningeal spread at time of diagnosis

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