Lung Adenocarcinoma with Cheek Dysesthesia as an Initial Symptom: A Case Report and Literature Review

Bandoh, Nobuyuki; Ichikawa, Haruyuki; Asahi, Atsuyoshi; Kono, Michihisa; Harabuchi, Shohei; Sato, Ryosuke; Uemura, Akihiro; Goto, Takashi; Yamaguchi, Tomomi; Kato, Yasutaka; Furukawa, Hironori; Takei, Hiroyuki; Harabuchi, Yasuaki

doi:10.1159/000502053

Cited by 2 publications

(3 citation statements)

References 13 publications

(17 reference statements)

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“…LUAD is a type of lung cancer with a high degree of malignancy, poor prognosis, and characterized by the increased likelihood of developing chest, liver, bone, and even intracranial metastasis [ 33 , 34 ]. At present, the majority of LUAD patients are diagnosed in the advanced stages and cannot be treated with surgery due to the presence of distant metastasis [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis

Song

Tang

2021

Bioscience Reports

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Background: Lung adenocarcinoma (LUAD) is the most frequent histological type of lung cancer, and its incidence has displayed an upward trend in recent years. Nevertheless, little is known regarding effective biomarkers for LUAD. Methods: The robust rank aggregation method was used to mine differentially expressed genes (DEGs) from the gene expression omnibus (GEO) datasets. The Search Tool for the Retrieval of Interacting Genes (STRING) database was used to extract hub genes from the protein–protein interaction (PPI) network. The expression of the hub genes was validated using expression profiles from TCGA and Oncomine databases and was verified by real-time quantitative PCR (qRT-PCR). The module and survival analyses of the hub genes were determined using Cytoscape and Kaplan–Meier curves. The function of KIF4A as a hub gene was investigated in LUAD cell lines. Results: The PPI analysis identified seven DEGs including BIRC5, DLGAP5, CENPF, KIF4A, TOP2A, AURKA, and CCNA2, which were significantly upregulated in Oncomine and TCGA LUAD datasets, and were verified by qRT-PCR in our clinical samples. We determined the overall and disease-free survival analysis of the seven hub genes using GEPIA. We further found that CENPF, DLGAP5, and KIF4A expressions were positively correlated with clinical stage. In LUAD cell lines, proliferation and migration were inhibited and apoptosis was promoted by knocking down KIF4A expression. Conclusion: We have identified new DEGs and functional pathways involved in LUAD. KIF4A, as a hub gene, promoted the progression of LUAD and might represent a potential therapeutic target for molecular cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis

Song

Tang

2021

Bioscience Reports

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“…was not expected, and it was found by chance. Patients with lung cancer are at a higher risk of developing bone metastases (around 40%), but sphenoid bone metastasis is rarely seen [1][2][3] .…”

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“…Symptoms resulting from metastatic compression and compression of cranial nerves (such as ocular symptoms, headache, and facial dysesthesia) may occur and the physician should always be aware of them 2,4 .…”

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Sphenoid bone metastasis in lung cancer: An unusual finding

Braga¹,

Costa²,

Santos³

2022

Pneumon

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A 68-year-old man with a recent diagnosis of small cell lung carcinoma, presented for a routine evaluation at our local lung cancer department, aiming to start treatment with carboplatin and etoposide. During the evaluation he seemed disoriented and complained of a headache. On physical examination only spatiotemporal disorientation stood out on the neurologic examination, with no other changes to report. Blood tests revealed hyponatremia, and elevated creatinine, alkaline phosphatase, gamma-GT, bilirubin, C reactive protein and procalcitonin. He was then admitted and treated for possible urinary infection, later confirmed by positive urine and blood cultures for Escherichia coli. Considering maintained symptoms, he was further investigated with a head CT scan with contrast to rule out brain metastases and it end up revealing a sphenoidal osteolytic lesion measuring 20×20×14 mm (Figure 1A), in addition to other smaller cranial bone metastases. Head MRI was also requested to allow a better characterization, showing an osteolytic lesion centered on the right paramedian region of the basisphenoid, with pronounced hyperintensity on T2-FLAIR images (Figure 1B), and homogeneous signal enhancement after contrast administration (Figures 1C and 1D).The case presented poses an unusual finding. Although imaging study was performed to clarify the presence of brain metastases, the sphenoid metastasis

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Lung Adenocarcinoma with Cheek Dysesthesia as an Initial Symptom: A Case Report and Literature Review

Cited by 2 publications

References 13 publications

Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis

Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis

Sphenoid bone metastasis in lung cancer: An unusual finding

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