Lung Cancer Pathogenesis Associated With Wood Smoke Exposure

Delgado, Javier; Martinez, Luis; Sánchez, Therasa T.; Ramìrez, Alejandra; Iturria, Cecilia; González-Ávila, Georgina

doi:10.1378/chest.128.1.124

Cited by 57 publications

(38 citation statements)

References 22 publications

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“…(23,24) Its association with lung cancer, through pathogenic mechanisms similar to those of tobacco smoke, has also been mentioned. (25) In communities in the semiarid area of the Northeast region, as well as in the Amazonian states and the state of Minas Gerais, projects for implementing the use of ecological stoves are being developed. This stove is affordable, uses less wood and causes less environmental pollution.…”

Section: Discussionmentioning

confidence: 99%

Estudo comparativo de sintomas respiratórios e função pulmonar em pacientes com doença pulmonar obstrutiva crônica relacionada à exposição à fumaça de lenha e de tabaco

et al. 2008

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Comparative study of respiratory symptoms and lung function alterations in patients with chronic obstructive pulmonary disease related to the exposure to wood and tobacco smoke* Estudo comparativo de sintomas respiratórios e função pulmonar em pacientes com doença pulmonar obstrutiva crônica relacionada à exposição à fumaça de lenha e de tabaco AbstractObjective: To describe and analyze clinical symptoms and spirometric alterations of patients with chronic obstructive pulmonary disease (COPD) and history of exposure to wood and tobacco smoke. Methods: We retrospectively evaluated data related to 170 patients distributed into 3 groups: 34 exposed only to wood smoke, 59 patients exposed only to tobacco smoke and 77 patients exposed to both. Results: The groups did not differ significantly in terms of age (p = 0.225) or degree of exposure, considering each type of exposure in isolation or in combination (p = 0.164 and p = 0.220, respectively). Females predominated in the group exposed to wood smoke. There were no differences among the groups regarding respiratory symptoms (p > 0.05), and moderate dyspnea predominated in the three groups (p = 0.141). The group exposed to wood smoke presented higher percentages of forced expiratory volume in one second/forced vital capacity ratio and of forced expiratory volume in one second (p < 0.05). Positive results on bronchodilator testing occurred more frequently in the group exposed to tobacco smoke. The percentage of severe and extremely severe obstruction was significantly higher in the group exposed to tobacco smoke (44.1%) than in that exposed to wood smoke (11.8%; p = 0.006). Conclusions: Respiratory symptoms and pulmonary function alterations consistent with COPD were observed in the groups of patients exposed to wood smoke. However, those alterations were not as significant as the alterations observed in the groups exposed to tobacco smoke. This study emphasizes the importance of prospective studies in evaluating the risk of wood-smoke-related COPD in Brazil, as well as the need for preventive measures in this area.Keywords: Pulmonary disease, chronic obstructive; Smoking; Air pollution, indoor; Smoke. ResumoObjetivo: Descrever e analisar sintomas respiratórios e alterações espirométricas em pacientes portadores de doença pulmonar obstrutiva crônica (DPOC), com história de exposição à fumaça de lenha e de tabaco. Métodos: Foram avaliados retrospectivamente dados de 170 pacientes distribuídos em 3 grupos: 34 pacientes expostos somente à fumaça de lenha, 59 pacientes, somente à de tabaco e 77 pacientes expostos a ambas. Resultados: Os grupos não diferiram quanto a idade (p = 0,225) e grau de exposição, considerando cada tipo de exposição isoladamente ou em associação (p = 0,164 e p = 0,220, respectivamente). No grupo exposto à fumaça de lenha predominou o sexo feminino. Não houve diferença entre os grupos quanto à freqüência dos sintomas respiratórios (p > 0,05), e houve predominância de grau moderado de dispnéia nos três grupos (p = 0,141). O grupo exposto à fumaça de ...

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Section: Discussionmentioning

confidence: 99%

Estudo comparativo de sintomas respiratórios e função pulmonar em pacientes com doença pulmonar obstrutiva crônica relacionada à exposição à fumaça de lenha e de tabaco

et al. 2008

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“…32 In a study in a Mexican population, 38.7% of the cases of LC occurred in non-smoker patients with long-term home exposure to biomass smoke, with no exposure to other carcinogens. 49 In women from India, it was observed that the use of biomass fuel increased the risk for LC (OR: 3.59; 95% CI: 1.08-11.97). 50 It has recently been observed in sputum samples that there is deterioration in the DNA of individuals exposed to biomass smoke compared to those who use liquid gas for cooking, and it seems to be at least partially mediated by oxidative stress generated by the inhalation of particles and benzene.…”

Section: Lung Cancermentioning

confidence: 99%

Indoor Air Contaminants and Their Impact on Respiratory Pathologies

Fernández

Álvarez

González‐Barcala

et al. 2013

Archivos de Bronconeumología (English Edition)

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“…Lung cancer incidence was higher in women than in men, particularly in the never-smoker group; probably because this group included WS patients, and women are exposed to wood smoke for more hours than men [6,8]. …”

Section: Discussionmentioning

confidence: 99%

“…The use of wood as fuel, particularly in rural areas, could be a potential risk factor for lung cancer, but the evidence confirming that wood smoke induces lung cancer is still not enough [5,6]. Nevertheless, the International Agency for Research on Cancer concluded that biomass smoke (mainly wood) is ‘probably carcinogenic to humans (Group 2A)' on the basis of the studies that demonstrated molecular and cytogenetic effects in humans and in experimental animals [7].…”

Section: Introductionmentioning

confidence: 99%

Differences in Plasma MMPs and TIMPs Protein Expression and Chemotherapy Response in Patients with Tobacco- or Wood-Smoke-Induced Lung Cancer

González-Ávila

Delgado²,

Mendoza-Posada³

et al. 2012

Respiration

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Background: One of the risk factors associated with lung cancer in never-smoker patients is wood smoke exposure (WS). However, information about its clinical and molecular characteristics remains scant. Objective: This was to analyze - in plasma from patients with tobacco- or wood-smoke-induced lung cancer - whether the enzymatic activity and concentration of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) differ, and to determine whether there was a correlation between these indicators of the metastatic potential and the first-line chemotherapy response. Methods: Patients were classified according to lung cancer associated with: the smoking of tobacco (T), WS and where no association with a known risk factor (N) could be established. The gelatinase activity of plasma MMP was analyzed by radiolabeled substrate degradation and zymography assay. Protein expression of MMPs and TIMPs was evaluated by Western blot densitometry analysis. Results: The 26.9% WS patients had a better response to therapy in comparison with the T group (OR = 4.9, 95% CI = 1.25-20.15; p = 0.019). The lowest gelatinase activity was observed in WS subjects, in comparison with T and N subjects (96.7 ± 15.9, 182.9 ± 31.5 and 163.3 ± 22.7 µg of degraded gelatin/mg of incubated plasma protein, respectively; p < 0.025); this enzymatic activity corresponded to MMP-2. The highest MMP-2, MMP-9, MT1-MMP and TIMP-1 plasma levels were observed in T subjects. Conclusion: Tobacco and wood smoke have different effects on MMP and TIMP synthesis and gelatinase activity, directly influencing lung cancer metastatic potential and chemotherapy response.

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Lung Cancer Pathogenesis Associated With Wood Smoke Exposure

Cited by 57 publications

References 22 publications

Estudo comparativo de sintomas respiratórios e função pulmonar em pacientes com doença pulmonar obstrutiva crônica relacionada à exposição à fumaça de lenha e de tabaco

Estudo comparativo de sintomas respiratórios e função pulmonar em pacientes com doença pulmonar obstrutiva crônica relacionada à exposição à fumaça de lenha e de tabaco

Indoor Air Contaminants and Their Impact on Respiratory Pathologies

Differences in Plasma MMPs and TIMPs Protein Expression and Chemotherapy Response in Patients with Tobacco- or Wood-Smoke-Induced Lung Cancer

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