Lung cancer metastasis to the breast mimicking inflammatory breast carcinoma on imaging

Malek, Daniel; Buccheri, Sebastiano; Dey, Courtney B.; Şamli, Billur; Plemmons, John

doi:10.1016/j.radcr.2019.09.024

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…In our study, the most common symptoms were skin edema and painless breast lesions. Edema of the skin may be due to the rapid growth of metastatic cancer, which could be misdiagnosed as inflammatory breast carcinoma (12). Both single and multiple lesions of unilateral breast were found in our study.…”

Section: Discussionmentioning

confidence: 48%

Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features

Wang

Jiang

et al. 2021

Transl Lung Cancer Res

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Background: Lung cancer metastases to the breast are less common and consequently have received much less attention in clinical practice. The purpose of this study was to provide a better understanding of clinical, ultrasonographic, and immunohistochemical features of breast metastases from primary lung cancer.Methods: This retrospective case series included patients with breast metastases from primary lung cancer between January 2012 and December 2020. Clinical features, ultrasonographic characteristics, and immunohistochemical findings were evaluated in this analysis.Results: In all, 7 cases (mean ± standard deviation age: 57.4±8.3 years; range, 49-70 years) were evaluated. The maximum size of breast lesions in 6 cases ranged from 1.2 to 4.5 cm, while 1 case showed a diffused pattern. Ultrasound features of breast metastases from lung cancer were irregular (5/7, 71.4%), indistinct (6/7, 85.7%), hypoechoic (7/7, 100.0%), and parallel (6/7, 85.7%) masses without calcification.Immunohistochemical staining test was positive for thyroid transcription factor 1 (TTF-1) in all patients (7/7, 100.0%), 3 cases (3/5, 60.0%) were negative for p63, 5 cases (5/5, 100.0%) were positive for cytokeratin 7 (CK7), 4 cases (4/5, 80.0%) were positive for napsin A. Conclusions:The ultrasonographic features of lung metastases to the breast are clinically important to understand. A known history of the primary lung cancer is of great importance when evaluating patients with a breast nodule. The presence of an ipsilateral lung cancer, breast nodule and axillary lymphadenopathy should be considered with pathological and immunohistochemical data to differentiate breast metastases from a primary breast malignancy in this setting.

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Section: Discussionmentioning

confidence: 48%

Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features

Wang

Jiang

et al. 2021

Transl Lung Cancer Res

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“…Similarly, widespread dermal lymphatic invasion in a tumor metastasizing to the breast via the lymphatic route can be challenging when differentiating from a inflammatory breast carcinoma. 17,18 Khalifeh et al presented a case of metastatic peritoneal serous carcinoma in punch biopsy material, which was interpreted as inflammatory breast carcinoma due to diffuse tumor embolism in dermal lymphatics. 19 Among the non-hematopoietic metastatic breast neoplasia series in the literature, one of the most comprehensive is the series of Zhou et al In their study of 238 cases, 77.7% were diagnosed correctly at the first evaluation.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metastatic Neoplasms to the Breast

Özşen,

Tolunay,

Polatkan

et al. 2023

Int J Surg Pathol

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Objective When the clinical presentation is related to the metastatic mass and a radiologically solitary tumor focus is detected, especially in cases where clinical information is not taken into account or is insufficient, if a possible metastatic neoplasia is not kept in mind then it is possible to evaluate the tumor as a primary breast neoplasm. In this study, it is aimed to present our cases of non-hematopoietic metastatic neoplasms and to evaluate the clinicopathological features that may aid in distinguishing metastatic from primary neoplasms. Material and Methods This study includes cases diagnosed with metastatic non-hematopoietic breast neoplasm in breast resection materials in our center, between the years 2010–2023. All cases were analyzed retrospectively by evaluating clinicopathological features. Results Of the 15 subjects included in the study, 11 (73%) were female and 4 (27%) were male. The mean age of the patients were 46.9 ranged from 22 to 63 years. The most frequent metastatic malignancy was carcinoma (60%), followed by melanoma (33%) and sarcoma (7%). Of the 9 patients with metastatic carcinoma, the primary tumor originated from the lungs in 4, from gastrointestinal system in 2, female genital tract in 2, and kidney in 1 patient. Sarcoma diagnosis was given in a single patient and the histology was a leiomyosarcoma originating from kidney. Conclusion A careful histomorphological and immunohistochemical evaluation and a detailed examination of the clinicoradiological data are critical to establish the right course in patient management, treatment plan and to correctly predict the prognosis.

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“…Several tumors can cause metastases to breast tissue including hematologic malignancies, malignant melanoma, rhabdomyosarcoma, and lung malignancies [ 8 ]. Dissemination can occur via lymphatic and hematologic routes [ 9 , 10 ]. Hematologic metastases most commonly appear as palpable single masses that do not display skin changes or nipple discharge [ 9 ].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Breast Metastasis from Neuroendocrine Carcinoma of the Lung: A Case Report and Review of the Literature

et al. 2020

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Breast metastasis originating from non-mammary tumors is an uncommon event accounting for 0.5–6.6% of all breast neoplasms. The primary malignancies that reportedly metastasize to the breast most frequently are hematologic malignancies, such as leukemia and lymphoma and malignant melanoma. Breast cancer metastasis resulting from a primary lung neoplasm is significantly less commonly described in the literature. Herein, we present the unusual case of a patient with metastatic disease to the breast from a primary lung tumor.

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Lung cancer metastasis to the breast mimicking inflammatory breast carcinoma on imaging

Cited by 9 publications

References 7 publications

Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features

Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features

Metastatic Neoplasms to the Breast

Breast Metastasis from Neuroendocrine Carcinoma of the Lung: A Case Report and Review of the Literature

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