Lung cancer induction by crystalline silica: Relationships to granulomatous reactions and host factors

Saffiotti, Umberto; Stinson, Sherman F.

doi:10.1080/10590508809373350

Cited by 19 publications

(10 citation statements)

References 20 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, an increased number of a-smooth muscle actin-positive fibroblasts was observed at 1 week after instillation following observation of acute inflammatory foci, which showed positive immunolabelings for TNF-a at 24 hr after instillation. Experimental silicosis in rats showed predominant granulomatous nodules (Saffiotti and Stinson 1988) rather than fibrotic nodules. Lung lesions in animals are generally less old (immature), and they rarely become as densely fibrotic as those seen in humans (Green, Vallyathan, and Hahn 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Another well-known health outcome associated with silica exposure is an increase in the incidence of autoimmune disorders Parks, Conrad, and Cooper 1999) including rheumatoid arthritis (Rosenman, Moore-Fuller, and Reilly 1999), scleroderma (Martin et al 1999), systemic lupus erythematosus (Parks and Cooper 2006), and antineutrophilic cytoplasmic antibody-related nephritis (Tervaert, Stegeman, and Kallenberg 1998). Experimental exposure of crystalline silica is known to cause granuloma formation (Huang et al 2001;Kumar 1989;Langley et al 2004Langley et al , 2010Saffiotti and Stinson 1988) and/or fibrosis (Porter et al 2004) in the lungs of rats. In a previous chronic experiment, granulomatous inflammation consisting of epithelioid macrophages containing crystalline silica particles in the lung-associated lymph nodes was demonstrated in rats at 6 weeks (Friedetzky et al 1998), 76 days (Porter et al 2004), and 5 months (Huang et al 2001) and in mice at 1 week after inhalation of crystalline silica.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, silicosis patients often develop autoimmune diseases Parks, Conrad, and Cooper 1999). It has been reported that experimental chronic exposure to crystalline silica caused granuloma formation (Huang et al 2001;Kumar 1989;Langley et al 2004Langley et al , 2010Saffiotti and Stinson 1988) and/or fibrosis (Porter et al 2004) in rats. In addition, granulomatous inflammation, which consists of epithelioid macrophages containing crystalline silica particles, in lung-associated lymph nodes has been reported in rats exposed to crystalline silica (Friedetzky et al 1998;Huang et al 2001;Porter et al 2002).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pathological Study of Chronic Pulmonary Toxicity Induced by Intratracheally Instilled Asian Sand Dust (Kosa)

et al. 2012

View full text Add to dashboard Cite

Asian sand dust (ASD) events are associated with an increase in pulmonary morbidity and mortality. The number of ASD events has increased rapidly in the east Asian region since 2000. To study the chronic lung toxicity of ASD, saline suspensions of low doses (200 and 400 mg) and high doses (800 and 3,000 mg) of ASD were intratracheally instilled into ICR mice. Animals were sacrificed at 24 hr, 1 week, or 1, 2, or 3 months after instillation. Histopathological examination revealed that ASD induced acute inflammation at 24 hr after instillation. The acute inflammation was transient and subsided at 1 week and 1 month after instillation. At 2 and 3 months after instillation, focal infiltration of lymphocytes with accumulation of epithelioid macrophages, which is a suggestive finding of transformation to granuloma, and granuloma formation were occasionally observed. Aggregation of macrophages containing particles was observed in the pulmonary lymph nodes at 3 months after instillation in high-dose groups. Prolonged inflammatory foci (granuloma) and presence of ASD particles in pulmonary lymph nodes would have a chance to induce immunological modulation leading to adverse health effects in the exposed animals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pathological Study of Chronic Pulmonary Toxicity Induced by Intratracheally Instilled Asian Sand Dust (Kosa)

et al. 2012

View full text Add to dashboard Cite

show abstract

“…A sample of min-U-sil 5 a-quartz (MQZ, Pennsylvania Glass Sand Co., (Pittsburgh PA) was obtained through the Illinois Institute of Technology Research (Chicago, IL) and tested for biologic activity in vivo and in vitro (5,6,12,21). Chinese standard a-quartz (CSQZ), which is used as a standard sample in China (29), was obtained from Nanjing University (Nanjing, China).…”

Section: Silica Preparationsmentioning

confidence: 99%

“…Since the early 1980s, epidemiologic studies have reported the association of silicosis with an increased risk for lung cancer (2)(3)(4). Experimental treatment of rats with silica by inhalation or by intratracheal instillation induced high incidences of fibrosis-associated pulmonary carcinomas (2,3,(5)(6)(7). In cell culture assays, silica has been shown to stimulate the proliferation of fibroblasts (8) and alveolar epithelial cells (9,10) and to induce neoplastic transformation (11,12).…”

Section: Introductionmentioning

confidence: 99%

DNA Binding to Crystalline Silica Characterized by Fourier-Transform Infrared Spectroscopy

Mao¹,

Daniel²,

Whittaker³

et al. 1994

Environmental Health Perspectives

Self Cite

View full text Add to dashboard Cite

The interaction of DNA with crystalline silica in buffered aqueous solutions at physiologic pH has been investigated by Fourier-transform infrared spectroscopy (FT-IR). In aqueous buffer, significant changes occur in the spectra of DNA and silica upon coincubation, suggesting that a DNA-silica complex forms as silica interacts with DNA. As compared to the spectrum of silica alone, the changes in the FT-IR spectrum of silica in the DNA-silica complex are consistent with an Si-O bond perturbation on the surface of the silica crystal. DNA remains in a B-form conformation in the DNA-silica complex. The most prominent changes in the DNA spectrum occur in the 1225 to 1000 cm1 region. Upon binding, the PO_ asymmetric stretch at 1225 cm1 is increased in intensity and slightly shifted to lower frequencies; the PO-symmetric stretch at 1086 cm1 is markedly increased in intensity; and the band at 1053 cm-, representing either the phosphodiester or the C-O stretch of DNA backbone, is significantly reduced in intensity.In D20 buffer, the DNA spectrum reveals a marked increase in intensity of the peak at 1086 cm-1 and a progressive decrease in intensity of the peak at 1053 cm-1 when DNA is exposed to increasing concentrations of silica. The carbonyl band at 1688 cm-diminishes and shifts to slightly lower frequencies with increasing concentrations of silica. The present study demonstrates that crystalline silica binds to the phosphate-sugar backbone of DNA. The close proximity of the silica surface to the DNA molecule, brought about by this binding, may contribute to DNA strand breakage produced by silica-derived free radicals. The ability of silica to form stable complexes with DNA may play an important role in the mechanisms of silica-induced toxicity and carcinogenesis. -Environ Health Perspect 102(Suppl 10):1 65-171 (1994)

show abstract

Lung Cancer Induction by Silica in Rats, but not in Mice and Hamsters: Species Differences in Epithelial and Granulomatous Reactions

Saffiotti¹

1990

Environmental Hygiene II

View full text Add to dashboard Cite

Lung cancer induction by crystalline silica: Relationships to granulomatous reactions and host factors

Cited by 19 publications

References 20 publications

Pathological Study of Chronic Pulmonary Toxicity Induced by Intratracheally Instilled Asian Sand Dust (Kosa)

Pathological Study of Chronic Pulmonary Toxicity Induced by Intratracheally Instilled Asian Sand Dust (Kosa)

DNA Binding to Crystalline Silica Characterized by Fourier-Transform Infrared Spectroscopy

Lung Cancer Induction by Silica in Rats, but not in Mice and Hamsters: Species Differences in Epithelial and Granulomatous Reactions

Contact Info

Product

Resources

About