Lung cancer in patients younger than 40 years of age

Maruyama, Riichiroh; Yoshino, Ichiro; Yohena, Tomofumi; Uehara, Tadashi; Kanematsu, Takanori; Kitajima, Masachika; Teruya, Tsuyoshi; Ichinose, Yukito

doi:10.1002/jso.1096

Cited by 39 publications

(28 citation statements)

References 15 publications

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“…[12][13][14][15][16][17][18][19][20][21][22] In our study, the percentage of adenocarcinoma in the young male subgroup was significantly higher than that of the whole group. Although this analysis lacks a detailed smoking history, we think smoking is a major factor for this phenomenon.…”

Section: Discussionmentioning

confidence: 79%

Multicenter analysis of lung cancer patients younger than 45 years in Shanghai

Zhang

Chen

Zhen

et al. 2010

Cancer

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BACKGROUND:The treatment, prognosis, and outcomes of young lung cancer patients have not been fully explored. In addition, there is a pressing need to characterize this subgroup of patients, because there is a trend of increasing incidence in younger patients from Europe and Japan. METHODS: Consecutive, nonselected young patients (<45 years old) with pathologically diagnosed lung cancer treated at 175 qualified hospitals in the greater Shanghai area were included in this analysis. Incidence, prognostic factors, and treatment outcome of lung cancer patients from 2002 to 2006 were documented. A comparison with lung cancer patients of any age was also made. RESULTS: A total of 12,380 patients with nonsmall cell lung cancer were registered. Among them, 652 patients were between 15 and 45 years old. One-year, 3-year, and 5-year survival rates of lung cancer patients younger than 45 years were 49.87%, 26.68%, and 23.12%, respectively. TNM stage, treatment hospital (tertiary vs community hospital), sex, and cancer histology were confirmed as independent prognostic factors. Compared with lung cancer patients of any age in Shanghai, the percentage of adenocarcinoma in the young male subgroup was significantly higher (63.77% vs 43.19%, P < .001). Interestingly, median survival time of young lung cancer patients was similar with that of lung cancer patients of any age, but was significantly shorter than the median survival of middle-aged patients (45-60 years old). CONCLUSIONS: Median survival of the middle-aged group (45-60 years) was significantly longer than the young group (<45 years) and the old group (>60 years). Therefore, aggressive treatment modalities should be strongly considered for young lung cancer patients. Cancer 2010;116;3656-62.

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Section: Discussionmentioning

confidence: 79%

Multicenter analysis of lung cancer patients younger than 45 years in Shanghai

Zhang

Chen

Zhen

et al. 2010

Cancer

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“…Although several reports have shown no differences in the prognosis of surgically treated cases of lung cancer (Sugio et al 1992;Shimono et al 1994;Schönfeld et al 1999;Maruyama et al 2001;Skarin et al 2001), lung cancer in young adults is reported to be associated with a poor prognosis (Putnam et al 1997) and to be more aggressive (Antkowiak et al 1989;Whooley et al 2000). Furthermore, it has been reported that lung cancer in patients younger than 40 years of age is often more advanced at the time of diagnosis than in elderly patients (Pemberton et al 1983;Schönfeld et al 1999;Maruyama et al 2001;Skarin et al 2001). However, the biological features of lung cancer in young adults have not yet been fully elucidated.…”

mentioning

confidence: 97%

“…60 years of age or older, and it has been reported that, among lung cancer patients younger than 40 years of age, females are becoming increasingly affected and adenocarcinoma is becoming more common (Pemberton et al 1983;Antkowiak et al 1989;Sugio et al 1992;Shimono et al 1994;Putnam et al 1997;Schönfeld et al 1999;Whooley et al 2000;Maruyama et al 2001;Skarin et al 2001). Although several reports have shown no differences in the prognosis of surgically treated cases of lung cancer (Sugio et al 1992;Shimono et al 1994;Schönfeld et al 1999;Maruyama et al 2001;Skarin et al 2001), lung cancer in young adults is reported to be associated with a poor prognosis (Putnam et al 1997) and to be more aggressive (Antkowiak et al 1989;Whooley et al 2000).…”

mentioning

confidence: 99%

Correlation between Angiogenesis and p53 Expression in Lung Adenocarcinoma of Young Patients

Kondou

Nagayasu

Hidaka

et al. 2009

Tohoku J. Exp. Med.

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“…Some studies concluded that young patients had a longer survival [10,12,13,[15][16][17][18], although the authors sometimes acknowledged that they received more aggressive treatment, others found a shorter survival [19], and many studies did not find any survival difference between young and older patients [9,14,[21][22][23][24]. However, these results cannot be compared because the cut-off used to define young patients varies from 40 to 50 years, and the populations included in these studies are heterogeneous, sometimes limited to non-small cell lung cancer (NSCLC) or adenocarcinoma or restricted to patients who underwent surgery.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Lung Cancer in Patients Younger than 40 Years: A Prospective Multicenter Analysis in France

et al. 2018

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Objectives: The aim of this study was to describe the demographic and clinico-pathological characteristics of lung cancer in patients younger than 40 years. Materials and Methods: This was a prospective study performed within the Groupe Français de Pneumo-Cancérologie. Consecutive patients diagnosed with lung cancer before the age of 40 years were eligible. Data on demographics, medical history, clinico-pathological characteristics, treatment and overall survival were analysed. Results: In total, 146 patients were included from January 2011 to December 2013. Median age was 38 years (IQR: 34–40). Women accounted for 41%. Main histological type was adenocarcinoma (77%). Only 3% had a prior history of cancer, but a family history (first- or second-degree relatives) of cancer was reported in 80 (55%) patients; 85 and 50% were current or past smokers of tobacco and cannabis, respectively; 82% had stage IIIB/IV at diagnosis. Median overall survival was 15.3 (95% CI: 8.1–24.0) months in the whole population, 10.3 (95% CI: 12.5–14.2) months in stage IV and 15 (95% CI: 8.7–35.2) months in stage III. One- and two-year overall survival rates were 57% (95 CI: 49–65) and 31.5% (95 CI: 27–43), respectively. Compared to smokers, non-smokers were significantly younger and more often females. Median overall survival was not statistically different between smokers and non-smokers.

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Lung cancer in patients younger than 40 years of age

Abstract: This study suggests that the prognosis of young patients with lung cancer is at least equivalent to that of older patients; therefore, they should be managed according to the general therapeutic guidelines.

Cited by 39 publications

References 15 publications

Multicenter analysis of lung cancer patients younger than 45 years in Shanghai

Multicenter analysis of lung cancer patients younger than 45 years in Shanghai

Correlation between Angiogenesis and p53 Expression in Lung Adenocarcinoma of Young Patients

Characteristics of Lung Cancer in Patients Younger than 40 Years: A Prospective Multicenter Analysis in France

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