Characteristics of Lung Cancer in Patients Younger than 40 Years: A Prospective Multicenter Analysis in France

Bigay-Gamé, L.; Bota, Suzanna; Greillier, L.; Monnet, I.; Madroszyk, Anne; Corre, Romain; Mastroïanni, B.; Falchero, L.; Colineaux, Hélène; Lepage, Benoît; Chouaïd, C.; Investigators, Gfpc

doi:10.1159/000489784

Cited by 17 publications

(23 citation statements)

References 28 publications

(34 reference statements)

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“…In our study, 28.83% of the younger group smoked, which is lower than the proportions reported internationally, such as in Japan (47.4–66%) and the USA (80–93%) 12 , 20 , 41 , 42 , 54 – 56 . Nevertheless, the proportion of smokers in our study is consistent with those reported in Liu's and Hou's studies, with the proportions of lung cancer patients who were smokers reported as 28.40% and 28.81% in China, respectively 34 , 46 , in contrast, the proportion in our study was higher than that in the study by Laurence et al, which reported that approximately 14.0% of the lung cancer patients younger than 40 years in France and Peru were smokers 23 , 57 . A family history of cancer was regarded as a surrogate for a genetic predisposition for lung cancer in some previous studies 24 .…”

Section: Discussionsupporting

confidence: 92%

“…A Polish study suggested that patients younger than 50 years old were relatively more likely than their older counterparts to have had a mother who had had lung cancer (4.7% vs 3.0%; P < 0.001) and to have had a father who had had lung cancer (7.6% vs 4.1%, P < 0.001) 58 . Another study by Laurence et al reported that the relatives of 25% of the younger patients who had a family history of lung cancer had developed the disease before they were 45 years old, compared to less than 5% in the old group 23 . One study by Abbasowa et al reported that the proportions of the younger and older groups of patients who had a family history of cancer were 44.8% and 36.0%, respectively, and the difference was statistically significant 59 .…”

Section: Discussionmentioning

confidence: 98%

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Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China

Shi

Liang

et al. 2021

Sci Rep

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To explore the epidemiological characteristics and prognosis of lung cancer in patients aged under 45 years old in northern China. The population-based database about lung cancer cases aged under 45y selected form the Hebei Provincial Cancer Registry Center from 2010–2015. Mortality data of young death from 1973 to 1975, 1990 to 1992, and 2004 to 2005 were extracted from the national retrospective survey of death. Mortality rates were calculated by the mortality database above in this analysis. Consecutive, 954 non-selected younger patients (< 45 years) and 2261 selected older patients (≥ 45 years) with pathologically diagnosed lung cancer treated at the Fourth Hospital of Hebei Medical University were included as the hospital-based database. Epidemiological, treatment outcomes and prognosis status from 2010 to 2017 were documented. A comparison with younger and older patients was also made. Multivariate analysis with young lung cancer patients was calculated by Cox regression model. The younger lung cancer mortality rate tended to slightly increase in Hebei Province, from 1.04 per100 000 in 1973 to 2.01 per 100 000 in 2015, but the PDR tended to decrease over the last 40 years. There were 954 younger and 2261 older lung cancer patients included in the hospital-based database. The proportions of patients who were female (50.84% vs 34.85%), family history of cancer (12.37% vs 6.32%), advanced stage at diagnosis (65.46% vs 60.77%) and adenocarcinoma (65.27% vs 61.11%) were relatively higher in the younger group than in the older group. The median OS were 23.0 months and 27.0 months between younger and older, the OS difference existed between the two groups (P = 0.001). In the younger patients, Cox regression showed that a family history of cancer, symptoms at diagnosis, pathology, stage at diagnosis and surgery were confirmed as independent factors affecting the prognosis. Mortality rates among younger lung cancer patients showed an increasing trend in northern China. The younger account for small but have unique characteristics, with higher proportions of female, family history of cancer, adenocarcinoma and advanced stages than the older group and had a trend of worse OS.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China

Shi

Liang

et al. 2021

Sci Rep

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“…The prevalence of EGFR mutations varies widely between studies included in this systematic review, probably due to ethnicity and the retrospective nature of the studies. Only seven 11,14,[17][18][19]41,42 out of fourteen studies found statistically significant differences in the prevalence of EGFR mutations across age groups (see Table 1). However, four 12,15,18,19 out of these seven studies found a significantly higher percentage of EGFR mutations among older patients with LUAD.…”

Section: Genomic Profiling In Aya With Lung Cancermentioning

confidence: 99%

Genomic profiling in non-small-cell lung cancer in young patients. A systematic review

et al. 2021

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Lung cancer in young patients is an uncommon and understudied entity that harbors distinctive epidemiological, clinic-demographic, and genomic features. We carried out a systematic review of genomic profiling in young patients with lung cancer from 2010 to 2020 in the main electronic databases and selected 23 manuscripts. Lung cancer in young patients occurs more frequently in women with adenocarcinoma histology and at more advanced stages. Some studies report higher oncogenic genomic alteration in this population, with higher anaplastic lymphoma kinase rearrangements, a distinct profile of epidermal growth factor receptor mutations, and other novel genomic alterations. Although still uncommon, the implementation of next-generation sequencing (NGS) has shed some light on germline genomic alterations associated with lung cancer in young patients. Although outcomes when compared with the older population are conflicting, the overall prognosis is still poor in this subset of patients and efforts to find targetable genomic alterations should be made to improve survival.

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“…The disease features and treatment outcomes among young NSCLC patients in the US, Western Europe and East Asia have been frequently studied [6][7][8][9][10][11][12][13][14][15]. Commonly, these comprehensive investigations of single-institutional or multi-centre cancer databases have sought (1) to quantify the rates of driver mutations and/or germline mutations among those with advanced NSCLC and/or (2) to recognise opportunities to explore more aggressive multimodality treatment regimens among those with early-stage diseases.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive comparison between young and older-age non-small cell lung cancer patients at a public referral centre in Delhi, India

Vashistha¹,

Garg²,

Iyer³

et al. 2021

ecancer

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Purpose Given the increasing number of non-small cell lung cancer (NSCLC) patients in India, a comparative analysis between patients under 40 years and those of older age at a major public referral centre would provide insight into the phenotypic patterns of this group. Methods NSCLC patients who were accessioned within the lung cancer clinic database of the Pulmonary Medicine Department at the all India institute of medical sciences – Delhi between 2008 and 2019 were reviewed. Patients 40 years or younger and 60 years or older were selected and categorised as young and older patients, respectively. Baseline clinical characteristics, histologic profiles, treatments administered and survival outcomes were compared between both groups. Results Following the database review, 154 young and 1,058 older patients were selected for inclusion. Clinically, young patients were more often female (26.0% versus 14.5%, p < 0.001), retained a more independent performance status (64.1% versus 45.5%; p < 0.001) and never smoked (63.7 % versus 18.8%, p < 0.001). Regarding disease profiles, young patients were more frequently diagnosed with adenocarcinoma ( p < 0.001) and 12 young patients had adenoid cystic carcinoma. Rates of stage IV disease at presentation were higher among young patients (78.0% versus 63.0%, p < 0.001). Regarding treatment, no differences in systemic therapies administered or survival were identified. Conclusion In India, young NSCLC patients are frequently non-smokers and diagnosed with advanced disease. Despite better performance status, young patients do not share better outcomes. Efforts should be directed towards optimising intensive treatment for young patients.

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Characteristics of Lung Cancer in Patients Younger than 40 Years: A Prospective Multicenter Analysis in France

Cited by 17 publications

References 28 publications

Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China

Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China

Genomic profiling in non-small-cell lung cancer in young patients. A systematic review

A comprehensive comparison between young and older-age non-small cell lung cancer patients at a public referral centre in Delhi, India

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