Lung and airway shape in neuroendocrine cell hyperplasia of infancy

Mastej, Emily; DeBoer, Emily M.; Humphries, Stephen; Cook, Marlijne C; Hunter, Kendall S.; Liptzin, Deborah R.; Weinman, Jason P.; Deterding, Robin R.

doi:10.1007/s00247-018-4189-6

Cited by 10 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, the KEGG and GO analyses of the overlapping genes revealed significant differences among the different tissues (Figures S1 and S2). For example, we found that the heart exhibits tissuespecific regulation of cell cycle function, while the liver exhibits tissue-specific regulation of cell proliferation function, and the lung exhibits tissue-specific regulation of cell shape function [33][34][35]. These findings suggest that different tissues have evolved specialized molecular mechanisms to regulate specific biological functions.…”

Section: Comparison Analysis Of Alternative Splicing Between Duroc An...mentioning

confidence: 77%

Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

Wang,

Li,

Liu

et al. 2024

Genes

View full text Add to dashboard Cite

Alternative splicing (AS) is a crucial mechanism in post-transcriptional regulation, contributing significantly to the diversity of the transcriptome and proteome. In this study, we performed a comprehensive AS profile in nine tissues obtained from Duroc (lean-type) and Luchuan (obese-type) pigs. Notably, 94,990 AS events from 14,393 genes were identified. Among these AS events, it was observed that 80% belonged to the skipped exon (SE) type. Functional enrichment analysis showed that genes with more than ten AS events were closely associated with tissue-specific functions. Additionally, the analysis of overlap between differentially alternative splicing genes (DSGs) and differentially expressed genes (DEGs) revealed the highest number of overlapped genes in the heart and skeletal muscle. The novelty of our study is that it identified and validated three genes (PYGM, MAPK11 and CAMK2B) in the glucagon signaling pathway, and their alternative splicing differences were highly significant across two pig breeds. In conclusion, our study offers novel insights into the molecular regulation of diverse tissue physiologies and the phenotypic differences between obese- and lean-type pigs, which are helpful for pig breeding.

show abstract

Section: Comparison Analysis Of Alternative Splicing Between Duroc An...mentioning

confidence: 77%

Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

Wang,

Li,

Liu

et al. 2024

Genes

View full text Add to dashboard Cite

show abstract

“…NECs release bombesin, probably involved in the pathogenesis of small airway obstruction [ 29 ]. Mastej et al demonstrated that lung and airway appearances in patients with NEHI presented an increased anteroposterior diameter, suggesting that also this criterion might be considered in the diagnostic criteria [ 30 ]. As demonstrated by Doan et al, the level of serum glycoprotein KL-6 might be a useful biomarker to distinguish NEHI from more severe neonatal surfactant metabolism disorders.…”

Section: Resultsmentioning

confidence: 99%

Interstitial Lung Disease in Children: “Specific Conditions of Undefined Etiology” Becoming Clearer

et al. 2022

View full text Add to dashboard Cite

Background: Children’s interstitial lung disease (chILD) is a rare group of pediatric lung diseases affecting the lung interstitium diffusely. In this work, we focused our attention on a specific infant group of chILD, also known as “specific conditions of undefined aetiology”, including pulmonary interstitial glycogenosis (PIG) and neuroendocrine cell hyperplasia of infancy (NEHI). Methods: PubMed was searched to conduct this narrative review. We searched for articles in English using the following keywords: (1) neuroendocrine cell hyperplasia of infancy; (2) NEHI; (3) pulmonary interstitial glycogenosis; (4) PIG; (5) chILD. Results: An increasing interest and insight into these two conditions have been reported. The updated literature suggests that it is possible to look at these disorders as a continuum of diseases, rather than two different entities, since they share a pulmonary dysmaturity. Conclusions: NEHI and PIG are featured by dysmaturity of airway development and consequent respiratory distress. Understanding the underlying pathogenic mechanisms would lead to identifying new targeted therapies to ameliorate the mortality and morbidity of these rare conditions.

show abstract

“…When tested and verified, the automated AAI was able to capture bronchiectasis in cystic fibrosis patients and was positively correlated with expert bronchiectasis scores in different scanners and reconstruction protocols. The automatic bronchiectasis score calculated using this method is a sensitive and objective indicator of research and clinical care [ 6 ].…”

Section: Related Workmentioning

confidence: 99%

Detection and Classification of Bronchiectasis Based on Improved Mask-RCNN

et al. 2022

View full text Add to dashboard Cite

Bronchiectasis is defined as a permanent dilation of the bronchi that can cause pulmonary ventilation dysfunction. CT examination is an important means of diagnosing bronchiectasis. It can also be used in severity scoring. Current studies on bronchiectasis have focused on high-resolution CT (HRCT), ignoring the more common low-dose CT (LDCT). Methodologically, existing studies have not adopted an authoritative standard to classify the severity of bronchiectasis. In effect, the accuracy of detection and classification needs to be improved for practical application. In this paper, the ACER image enhancement method, RDU-Net lung lobe segmentation method and HDC Mask R-CNN model were proposed to detect and classify bronchiectasis. Moreover, a Python-based system was developed: after inputing an LDCT image of a patient’s lung, it can automatically perform a series of processing, then call on the trained deep learning model for detection and classification, and automatically obtain the patient’s bronchiectasis final score according to the Reiff and BRICS scoring criteria. In this paper, the mapping relationship between original lung CT image data and bronchiectasis scoring system was established. The accuracy of the method proposed in this paper was 91.4%; the IOU, sensitivity and specificity were 88.8%, 88.6% and 85.4%, respectively; and the recognition speed of one picture was about 1 s. Compared to a human doctor, the system can process large amounts of data simultaneously, quickly and efficiently, with the same judgment accuracy as a human doctor. Doctors only need to judge the uncertain cases, which significantly reduces the burden of doctors and provides a useful reference for doctors to diagnose the disease.

show abstract

Lung and airway shape in neuroendocrine cell hyperplasia of infancy

Abstract: Lung and airway shapes were different between children with NEHI and control children in this cohort. Children with NEHI had an increased anteroposterior diameter of their lungs that might be useful in the diagnostic criteria.

Cited by 10 publications

References 19 publications

Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

Interstitial Lung Disease in Children: “Specific Conditions of Undefined Etiology” Becoming Clearer

Detection and Classification of Bronchiectasis Based on Improved Mask-RCNN

Contact Info

Product

Resources

About