Lung Adenocarcinoma Incidence Rates and Their Relation to Motor Vehicle Density

Jackson, Haley; Bina, William F.

doi:10.1158/1055-9965.epi-08-0741

Cited by 44 publications

(35 citation statements)

References 13 publications

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“…The incidence rates of squamous cell and small-cell carcinomas of the lung increased during the 1970s, peaked at the beginning of the 1980s, and decreased thereafter, whereas the incidence rate of adenocarcinoma of the lung first decreased from about 1998. An association between NO x air pollution and adenocarcinoma of the lung has been suggested as the explanation for these different time trends, supported by ecological correlations between the incidence rates of adenocarcinomas and vehicle densities at county area level (29,30). Use of individual exposure assessments in our study did not confirm this hypothesis because we observed stronger associations between NO x concentrations and risk for squamous cell and small-cell carcinomas than for adenocarcinoma of the lung.…”

Section: Discussioncontrasting

confidence: 58%

Air Pollution from Traffic and Risk for Lung Cancer in Three Danish Cohorts

Raaschou-Nielsen

Bak

Sørensen

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Air pollution is suspected to cause lung cancer. The purpose was to investigate whether the concentration of nitrogen oxides (NO x ) at the residence, used as an indicator of air pollution from traffic, is associated with risk for lung cancer.Methods: We identified 679 lung cancer cases in the Danish Cancer Registry from the members of three prospective cohorts and selected a comparison group of 3,481 persons from the same cohorts in a case-cohort design. Residential addresses from January 1, 1971, were traced in the Central Population Registry. The NO x concentration at each address was calculated by dispersion models, and the time-weighted average concentration for all addresses was calculated for each person. We used Cox models to estimate incidence rate ratios after adjustment for smoking (status, duration, and intensity), educational level, body mass index, and alcohol consumption.Results: The incidence rate ratios for lung cancer were 1.30 [95% confidence interval (95% CI), 1.07-1.57] and 1.45 (95% CI, 1.12-1.88) for NO x concentrations of 30 to 72 and >72 μg/m

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Section: Discussioncontrasting

confidence: 58%

Air Pollution from Traffic and Risk for Lung Cancer in Three Danish Cohorts

Raaschou-Nielsen

Bak

Sørensen

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Likewise, average NO 2 concentrations reported by the EPA have increased 169% from 1960 to 1979, followed by a decline of 44% in the monitoring concentration of NOx from 1980 to 2007. (4,5) The peak year of the incidence curve was 20 years later than the peak of the curve of NOx pollutants.…”

Section: Resultsmentioning

confidence: 99%

“…Later research proposed the possibility that lung adenocarcinoma is a disease whose long-term incidence trend is associated with variation of nitrogen oxides (NOx), a family including Nitric oxide (NO) and nitrogen dioxide (NO 2 ), and several other nitrogen-oxygen compounds of air pollution, and the geographic distribution pattern of lung adenocarcinoma is highly related to motor vehicle density, a major source of NOx (R 2 0.8052). [3,4] Given that breast cancers are also diagnosed as adenocarcinoma and its incidence rises along with industrialization, further study is needed to explore possible linkages between the upward-downward trend of breast cancer incidence and air quality. In addition to comparing the long-term trend, an analysis of the geographical pattern is needed to see whether there is a doseresponse relationship between incidence and the level of air pollution in different areas.…”

Section: Introductionmentioning

confidence: 99%

Correlation of white female breast cancer incidence trends with nitrogen dioxide emission levels and motor vehicle density patterns

Fan

Bina

2011

Breast Cancer Res Treat

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The long-term trend of female breast cancer incidence rates in the United States and some European countries demonstrates a similar pattern: an increasing trend in the last century followed by a declining trend in this century. The well-known risk factors cannot explain this trend. We compared the breast cancer incidence trends obtained from SEER data with the trend of nitrogen dioxides (NOx) emission and monitoring data as well as motor vehicle density data. The upward followed by downward trend of NOx is similar to the breast cancer incidence trend but with an offset of 20 years earlier. Motor vehicles are the major source of NOx emissions. The geographic distribution of motor vehicles density in 1970 in the observed US counties is positively correlated with breast cancer incidence rates (R(2) 0.8418, the correlation coefficient = 0.9175) in 1980-1995. Because both the time trend and geographic pattern are associated with breast cancer incidence rates, further studies on the relationship between breast cancer and air pollution are needed.

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“…For instance, residences near industrial areas are significantly associated with various disease incidences including lung cancer (37)(38)(39); green spaces have a positive impact on health, including decreasing respiratory disease mortality (40)(41)(42), while the impact may not always significant in certain areas (43). Meanwhile, since high traffic volume increases incidence rate of pulmonary adenoma (44,45), living within 100 m from highways has a negative impact on respiratory health for both children (46,47) and adults (48). Current studies have respectively explored the indoor and outdoor factors on respiratory diseases.…”

Section: Introductionmentioning

confidence: 99%

Correlation analysis of lung cancer and urban spatial factor: based on survey in Shanghai

Wang

Zhao

et al. 2016

J. Thorac. Dis.

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Background: The density of particulate matter (PM) in mega-cities in China such as Beijing and Shanghai has exceeded basic standards for health in recent years. Human exposure to PMs has been identified as traceable and controllable factor among all complicated risk factors for lung cancer. While the improvement of air quality needs tremendous efforts and time, certain revision of PM's density might happen associated with the adjustment of built environment. It is also proved that urban built environment is directly relevant to respiratory disease. Studies have respectively explored the indoor and outdoor factors on respiratory diseases. More comprehensive spatial factors need to be analyzed to understand the cumulative effect of built environment upon respiratory system. This interdisciplinary study examines the impact of both indoor (including age of housing, interval after decoration, indoor humidity etc.) and outdoor spatial factors (including density, parking, green spaces etc.) on lung cancer. Methods: A survey of lung cancer patients and a control group has been conducted in 2014 and 2015. A total of 472 interviewees are randomly selected within a pool of local residents who have resided in Shanghai for more than 5 years. Data are collected including their socio-demographic factors, lifestyle factors, and external and internal residential area factors. Regression models are established based on collected data to analyze the associations between lung cancer and urban spatial factors. Results: Regression models illustrate that lung cancer presents significantly associated with a number of spatial factors. Significant outdoor spatial factors include external traffic volume (P=0.003), main plant type (P=0.035 for trees) of internal green space, internal water body (P=0.027) and land use of surrounding blocks (P=0.005 for residential areas of 7-9 floors, P=0.000 for residential areas of 4-6 floors, P=0.006 for business/ commercial areas over 10 floors, P=0.005 for business/commercial areas of 7-9 floors, P=0.043 for business/ commercial areas of 4-6 floors). Indoor spatial factors include age of housing (P=0.003) and indoor humidity (P=0.000). Conclusions: The findings support the hypothesis that both indoor and outdoor spatial factors are independently associated with lung cancer incidence. Certain principles based on the modeling results are proposed to revise the criteria for lung cancer screening of high-risk individuals. It also provides empirical evidence for urban planning and design to improve built environment with more thorough consideration of respiratory health.

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Lung Adenocarcinoma Incidence Rates and Their Relation to Motor Vehicle Density

Cited by 44 publications

References 13 publications

Air Pollution from Traffic and Risk for Lung Cancer in Three Danish Cohorts

Air Pollution from Traffic and Risk for Lung Cancer in Three Danish Cohorts

Correlation of white female breast cancer incidence trends with nitrogen dioxide emission levels and motor vehicle density patterns

Correlation analysis of lung cancer and urban spatial factor: based on survey in Shanghai

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