Luminescence properties and cell uptake analysis of Y2O3:Eu, Bi nanophosphors for bio-imaging applications

Chávez-García, D.; Sengar, Prakhar; Juárez-Moreno, Karla; Flores, Dora–Luz; Calderon, Irene; Barrera, Jaime Bermejo; Hirata, G.A.

doi:10.1016/j.jmrt.2020.11.071

Cited by 22 publications

(9 citation statements)

References 32 publications

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“…Novel approaches to improve radiotherapy by nanotechnology are now attempted to overcome radioresistance of melanoma tumors [ 45 , 46 ]. Indeed, various nanomaterials are known to induce cell apoptosis by mitochondrial injury [ 27 ]. Relevant biochemical events involve altered energy metabolism, mitochondrial outer membrane permeability, mitochondrial swelling, release of pro-apoptotic BCl-2 family proteins and loss of mitochondrial inner membrane potential, which eventually could decide cell fate [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, various nanomaterials are known to induce cell apoptosis by mitochondrial injury [ 27 ]. Relevant biochemical events involve altered energy metabolism, mitochondrial outer membrane permeability, mitochondrial swelling, release of pro-apoptotic BCl-2 family proteins and loss of mitochondrial inner membrane potential, which eventually could decide cell fate [ 27 ]. A promising strategy to enhance the biological effect of radiotherapy refers to the NPs induced sensitization of tumor cells without affecting normal tissue cells.…”

Section: Discussionmentioning

confidence: 99%

“…The main objective of the study was to systematically analyze the biological effects on A375 cells induced by either Y 2 O 3 NPs or superficial X-ray radiation to eventually reveal the potential role of Y 2 O 3 NPs during X-ray exposure. We believe these investigations are essential for biomedical cancer applications in the new field of theranostics where Y 2 O 3 NPs could be used as intracellular dosimetric sensors during X-ray treatment via bioimaging of tumors [ 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

et al. 2021

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The innovative strategy of using nanoparticles in radiotherapy has become an exciting topic due to the possibility of simultaneously improving local efficiency of radiation in tumors and real-time monitoring of the delivered doses. Yttrium oxide (Y2O3) nanoparticles (NPs) are used in material science to prepare phosphors for various applications including X-ray induced photodynamic therapy and in situ nano-dosimetry, but few available reports only addressed the effect induced in cells by combined exposure to different doses of superficial X-ray radiation and nanoparticles. Herein, we analyzed changes induced in melanoma cells by exposure to different doses of X-ray radiation and various concentrations of Y2O3 NPs. By evaluation of cell mitochondrial activity and production of intracellular reactive oxygen species (ROS), we estimated that 2, 4, and 6 Gy X-ray radiation doses are visibly altering the cells by inducing ROS production with increasing the dose while at 6 Gy the mitochondrial activity is also affected. Separately, high-concentrated solutions of 25, 50, and 100 µg/mL Y2O3 NPs were also found to affect the cells by inducing ROS production with the increase of concentration. Additionally, the colony-forming units assay evidenced a rather synergic effect of NPs and radiation. By adding the NPs to cells before irradiation, a decrease of the number of proliferating cell colonies was observed with increase of X-ray dose. DNA damage was evidenced by quantifying the γ-H2AX foci for cells treated with Y2O3 NPs and exposed to superficial X-ray radiation. Proteomic profile confirmed that a combined effect of 50 µg/mL Y2O3 NPs and 6 Gy X-ray dose induced mitochondria alterations and DNA changes in melanoma cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

et al. 2021

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“…[ 4 ]. One of the actively studied materials in this category is yttrium oxide (Y 2 O 3 ), which is considered as a suitable host matrix for ionic dopants (including rare-earth and transition-metal ions) in order to construct and develop solid-state optical devices [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Exciton Luminescence and Optical Properties of Nanocrystalline Cubic Y2O3 Films Prepared by Reactive Magnetron Sputtering

et al. 2022

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This paper presents a comprehensive study of the energy structure, optical characteristics, and spectral-kinetic parameters of elementary excitations in a high-purity nanocrystalline cubic Y2O3 film synthesized by reactive magnetron sputtering. The optical transparency gaps for direct and indirect interband transitions were determined and discussed. The dispersion of the refractive index was established based on the analysis of interference effects. It was found that the refractive index of the Y2O3 film synthesized in this study is higher in order of magnitude than that of the films obtained with the help of other technologies. The intrinsic emission of Y2O3 film has been discussed and associated with the triplet–singlet radiative relaxation of self-trapped and bound excitons. We also studied the temperature behavior of the exciton luminescence of Y2O3 for the first time and determined thermal activation barriers. The optical energy and kinetic parameters of cubic Y2O3 films were analyzed in comparison with those of the monoclinic films of yttrium oxide. The main difference between the optical properties of cubic and monoclinic Y2O3 films was established, which allowed for a supposition of their application prospects.

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“…In addition, Y2O3 is used as a host material for doping with different ions, especially with rare-earth and transition ions [7,8]. Optical properties of Y2O3-based materials usually well meet manufacturing requirements for creation of lightemitting diodes [9], color displays [10], lasers [11], solar cells [12], bio-imaging systems [13], etc.…”

Section: Introductionmentioning

confidence: 99%