Luminescence energy transfer detection of PSA in red region based on Mn2+-enhanced NaYF4:Yb, Er upconversion nanorods

Recent advances in nanomaterials for prostate cancer detection and diagnosis

“…Similarly, Zhang et al constructed a FRET-based sensor by complexing Mn 2+ -doped NaYF4:Yb,Er up-conversion nanorods with gold nanorods, resulting in a quenched luminescence due to the FRET between them. 97 The introduction of PSA disassembled the Mn 2+ -doped NaYF4:Yb,Er up-conversion nanorods with gold nanorods, recovering the luminescence for detection.…”

Preparation of gold nanoparticle coated NaYF4:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

“…For example, our group successfully constructed a luminescence energy transfer (LET) system in which NaYF 4 :Yb,Er UCNPs were used as the energy donors, and gold nanorods (GNRs) were used as the energy acceptors for bioassays and ion detection. [16][17][18] The LET system was widely used in biological detection, but its complex system construction made practical application difficult. Its application was limited by its emission rate because of its surface quenching, particularly for the large specific surface area/volume ratio of nanoparticles and relatively small crosssectional area of photon absorption.…”

“…First, hydrothermal synthesis of NaYF 4 :Yb,Er,Gd UCNPs was performed with the amphiphilic surfactant cetyltrimethylammonium bromide (CTAB). Then, the surfaces of the NaYF 4 :Yb,Er,Gd UCNPs were modified with poly(acrylic acid) (PAA) 17,18 , and the gold NPs coated on the UCNPs were prepared by introducing a reductant to the UCNPs and conjugating Ab 1 . When AFP was added, the binding affinity between AFP and Ab 1 resulted in a reduced distance between the gold NPs coated UCNPs, and the luminescence intensity of the UCNPs increased as the AFP concentration increased, which was attributed to SPR occurring.…”