Preparation of gold nanoparticle coated NaYF₄:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

Abstract

A novel surface plasmon resonance (SPR) enhanced upconversion (UC) luminescence system was designed for the detection of α-fetoprotein (AFP) by using gold nanoparticle (NP) coated NaYF4:Yb,Er,Gd upconversion nanoparticles (UCNPs) as probes.

Fluorescence immunosensor based on functional nanomaterials and its application in tumor biomarker detection

“…82 When the uorescent molecules are close to the surface of noble metal nanoparticles, the emission intensity of uorescent molecules is greatly enhanced, which is called metal enhanced uorescence (MEF). 83,84 Due to the enhanced uorescence of uorescent molecules, the MEF effect can effectively improve the sensitivity of the immunosensor. Xu et al, 85 constructed a uorescence sensor based on hybridization chain reaction (HCR) and MEF for sensitive detection of AFP (Fig.…”

Switching to the brighter lane: pathways to boost the absorption of lanthanide-doped nanoparticles

“…This enables harnessing the Purcell effect to enhance the UC emission. 50 However, above 100 nm in size, the extinction spectrum of gold NPs extends more decisively in the NIR. In that vein, it was observed by Fischer et al that larger gold NPs are better suited to enhance Er 3+ emission at 980 nm under 1520-nm excitation, due to increased scattering of large structures.…”