Lumbar Sympathetic Nerve Modulation Using Absolute Ethanol for the Treatment of Primary Lower-Extremity Hyperhidrosis: A Dose-Effect Pilot Study

Liu, Mingjuan; Ni, Huadong; Tao, Jiachun; Xie, Keyue

doi:10.12659/msm.928209

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Under the funding of the Zhejiang Medical and Health Platform's key project, we conducted research on the treatment technology of CT-guided absolute alcohol chemical destructive block of the thoracic sympathetic nerve chain to explore a new treatment technology for palmar hyperhidrosis ( 6 – 8 ). This technique has been effectively utilized for managing palmar hyperhidrosis, cephalic hyperhidrosis, axillary hyperhidrosis, perineal hyperhidrosis of the lower limbs, and Raynaud's syndrome ( 6 – 9 , 23 , 24 ), as well as a combined thoracic and lumbar sympathetic nerve block for palmar and foot hyperhidrosis ( 25 , 26 ). Resen et al conducted a study on the effectiveness of CT-guided chemical destruction of the thoracic sympathetic nerve chain with absolute alcohol in treating palmar hyperhidrosis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of CT-guided thoracic sympathetic nerve block and radiofrequency in the treatment of primary palmar hyperhidrosis

Zhang

Liu

et al. 2023

Front. Surg.

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BackgroundPrimary palmar hyperhidrosis (PPH) is a condition marked by an overactive secretion of the hand's exocrine glands and is frequently hereditary. The profuse sweating associated with this condition can significantly impair the patient's daily activities and quality of life.ObjectiveThe objective of this study was to compared the benefits and drawbacks of thoracic sympathetic block and thoracic sympathetic radiofrequency in the treatment of PPH.MethodsA retrospective analysis was conducted on 69 patients. They were divided into groups A and B according to their treatment. Group A (34 cases) received CT-guided percutaneous thoracic sympathetic nerve chain anhydrous alcohol chemical damage block, and group B (35 cases) received CT-guided percutaneous thoracic sympathetic nerve chain radiofrequency thermocoagulation.ResultsPalmar sweating disappeared immediately after the operation. The recurrence rates at 1, 3, 6, 12, 24, and 36 months were 5.88% vs. 2.86% (P > 0.05), 20.59% vs. 5.71% (P > 0.05), 32.35% vs. 11.43% (P < 0.05),32.35% vs. 11.43% (P < 0.05), 25% vs. 14.71% (P < 0.05), and 68.75% vs. 20.59% (P < 0.05), respectively. The incidence of intercostal neuralgia and compensatory hyperhidrosis was higher in group A compared with of group B (52.94% vs. 22.86%, P < 0.05; 55.88% vs. 22.86%, P < 0.05).ConclusionBoth methods were found to be effective in treating PPH, but thoracic sympathetic radiofrequency had a longer-term effect, a lower recurrence rate, and a lower incidence of intercostal neuralgia and compensatory hyperhidrosis than a thoracic sympathetic block.

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Section: Discussionmentioning

confidence: 99%

Comparison of CT-guided thoracic sympathetic nerve block and radiofrequency in the treatment of primary palmar hyperhidrosis

Zhang

Liu

et al. 2023

Front. Surg.

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“…45 The agent of choice is 2 to 3 mL of absolute ethanol, but 3 mL of phenol 7% has been used; other options include botulinum toxin, RFA, and laser ablation. 67 68 69 70 71 In one head-to-head study, it was noted that RFA resulted in fewer instances of post-sympathetic neuralgia compared with ethanol, but also a significantly decreased rate of efficacy at 8 weeks. 72 The procedure has been shown to produce favorable results with cutaneous hyperemia in the lower extremities sometimes occurring immediately afterward due to the resulting vasodilation.…”

Section: Ganglion and Plexus Blockadementioning

confidence: 99%

Agents Used for Nerve Blocks and Neurolysis

Majdalany

Lilly

et al. 2022

Semin intervent Radiol

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The recognition of pain and the treatments used for it are vital for all practitioners. Many types of pain can be treated in a locoregional fashion, which has significant implications not just for any individual patient but for society as a whole. These treatments are most effective when performed in a minimally invasive, image-guided fashion. Interventional radiologists should play a central role in providing these lifestyle-limiting treatments. This article describes the medications most typically used for spinal and extra-axial treatments in the management of patients in pain.

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Computed tomography-guided chemical renal sympathetic nerve modulation in the treatment of resistant hypertension: A case report

Luo¹,

Zhu²,

Yao³

et al. 2021

WJCC

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BACKGROUND Resistant hypertension (RH) has always been a difficult problem in clinical diagnosis and treatment. At present, there is no recognized safe and effective minimally invasive treatment. CASE SUMMARY An 80-year-old woman was admitted to hospital due to trigeminal neuralgia (TN). The patient had a history of RH for more than 10 years and her blood pressure (BP) was not well-controlled. Before the treatment for TN, we decided to perform chemical renal sympathetic denervation with ethanol in the Pain Department of our hospital. One year after the operation, she stopped taking antihypertensive drugs, and her BP was satisfactorily controlled within 4 years after surgery. CONCLUSION Computed tomography-guided chemical renal sympathetic modulation may be a feasible method for the treatment of RH.

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Lumbar Sympathetic Nerve Modulation Using Absolute Ethanol for the Treatment of Primary Lower-Extremity Hyperhidrosis: A Dose-Effect Pilot Study

Cited by 3 publications

References 6 publications

Comparison of CT-guided thoracic sympathetic nerve block and radiofrequency in the treatment of primary palmar hyperhidrosis

Comparison of CT-guided thoracic sympathetic nerve block and radiofrequency in the treatment of primary palmar hyperhidrosis

Agents Used for Nerve Blocks and Neurolysis

Computed tomography-guided chemical renal sympathetic nerve modulation in the treatment of resistant hypertension: A case report

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