Lumbar Spine Bone Density in Argentine Children

Abstract

It has been demonstrated that bone mineral density (BMD) in children and adolescents is influenced by individual height. The aim of the present work was to introduce a formula to include height in the BMD analysis. Postero-anterior (PA) (L2-L4) and lateral (L2-L3) lumbar BMD was assessed by dual X-ray absorptiometry (DXA) in 433 and 393, respectively, healthy Caucasian females from 2 to 20 years of age. A complete medical examination including weight, height, and Tanner puberal stage was performed in all the subjects. Bone age was assessed by left wrist radiographs and analyzed by the TW2 method to insure that it was within 1 year of chronological age. Bone mineral density adjusted for height (BMDcorr = BMC/projected area x height), was calculated for each individual. As analyzed by Tanner stage, both PA and lateral BMD increased up to stage 3, and there were no significant differences among stages 3-5. Results of BMDcorr variations related to Tanner stage suggested that the increase in lateral BMD before puberty might be related to height. PA BMDcorr increased up to Tanner stage 3, and there were no differences among stages 3-5. The BMDCORR approach can be used to get a more reliable analysis of BMD studies in children and adolescents.

Bone mineral density and urinary N‐acetyl‐β‐ d‐glucosaminidase activity in paediatric patients with idiopathic hypercalciuria

“…The estimation of BMD is influenced by bone size and can be underestimated in smaller individuals, and vice versa, overestimated in larger bones 29,32 , 33 . The poor correlations between anthropometric parameters and BMD in the present patients suggest low bone mass in children with IH, because body size is a better correlate of spinal BMD than the chronological age 29,32–34 . This was further confirmed by low BMDvol because volumetric bone density gives more reliable information than the areal data 23,35 .…”

Reference data for bone density and body composition measured with dual energy x ray absorptiometry in white children and young adults

“…[22][23][24][25][26] The main increase occurs during puberty, when concentrations of growth hormone as well as sex steroids increase; both are known to positively influence bone mineralisation. 27 28 Maximal increase in BMD and BMAD occurred around the age of 13 years in girls and approximately two years later in boys.…”

Genetic Determination of Colles' Fracture and Differential Bone Mass in Women With and Without Colles' Fracture

“…The values are expressed as bone content per unit area (g/cm 2 ) of the projected image of the region of interest (ROI), which is only an approximation of the volumetric density. Correction factors for this are subject to error, (59–63) because there is no closed formula that defines the size of the vertebrae or the femur. Importantly, DXA values are influenced by variation in the composition of soft tissues in the beam path of the ROI.…”