Reference data for bone density and body composition measured with dual energy x ray absorptiometry in white children and young adults

Sluis, Inge M. van der; Ridder, Maria A. J. de; Boot, Annemieke M.; Krenning, Eric P.; Keizer‐Schrama, Sabine M.P.F. de Muinck

doi:10.1136/adc.87.4.341

Cited by 311 publications

(200 citation statements)

References 44 publications

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“…Our findings confirm both observations, with no differences in leptin levels found between sexes when the cohort was analyzed as a whole or in PTN separately, but with female FTN having higher leptin and free leptin index than male FTN. Thus, this sexual dimorphism in leptin levels seems to be a late gestational event and, in the absence of differences in weight or ponderal index, points towards a higher fat content in females than in males already in late pregnancy, as shown at birth and throughout extrauterine life (23,24). sOB-R levels behave in an opposite fashion to leptin levels at birth (25), as in later stages of extrauterine life (6).…”

Section: Discussionmentioning

confidence: 99%

Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism

Martos‐Moreno¹,

Barrios²,

Pipaón³

et al. 2009

European Journal of Endocrinology

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Objective: To determine the influence of gestational age and fetal growth restriction on the cord blood adipokine profile, IGF1, and ghrelin levels, and their relationship with glucose metabolism. Study design: One hundred and ninety newborns (99 preterm and 91 full term) were studied and, according to their anthropometry at birth, classified as small (SGA) or adequate for gestational age (AGA). Methods: Venous cord blood serum levels of IGF1, IGF binding protein 3 (IGFBP-3), adiponectin, resistin, leptin, soluble leptin receptor (sOB-R), tumoral necrosis factor-a, interleukin 6 (IL-6), total ghrelin, and acylated ghrelin were determined and compared between preterm and full-term, as well as between SGA and AGA, newborns. Correlations with newborn weight, gestational age, and homeostatic model assessment (HOMA) index, as an index of insulin resistance, were determined. Results: Preterm newborns had higher HOMA, sOB-R, resistin, and IL-6 and lower IGF1, IGFBP-3, leptin, and adiponectin levels than full-term newborns. SGA had lower IGF1, IGFBP-3, leptin, IL-6, and adiponectin and higher sOB-R and total ghrelin than AGA newborns. Adiponectin and HOMA showed independent positive and negative correlations with gestational age respectively, but not with neonatal weight. Birth weight was correlated positively with IGF1 and leptin levels and negatively with total ghrelin ones. Conclusions: Our findings suggest that the lack of proper acquisition of adipose tissue by the fetus either due to prematurity or to fetal growth restriction is associated with changes in the cord blood adipokine profile that may contribute to the impairment of glucose metabolism.

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Section: Discussionmentioning

confidence: 99%

Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism

Martos‐Moreno¹,

Barrios²,

Pipaón³

et al. 2009

European Journal of Endocrinology

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“…21 Ageand gender-specific reference data from a cohort of white European children were used to calculate the vBMD z scores. 22 …”

Section: Bone Mineral Assessmentmentioning

confidence: 99%

Cow's Milk Allergy and Bone Mineral Density in Prepubertal Children

Mailhot

Perrone²,

Alos

et al. 2016

Pediatrics

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BACKGROUND AND OBJECTIVES: Recent data suggest that cow's milk allergy (CMA) has become more persistent, prolonging treatment via strict elimination of cow's milk products into a period of skeletal growth. The objectives of this study were to compare bone mineral density (BMD), vitamin D status, and dietary intakes of calcium and vitamin D between prepubertal children with persistent CMA and those with non-cow's milk food allergies (NCMA) as control subjects and to assess the use of and compliance to calcium and vitamin D supplementation among children with persistent CMA.

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“…The precision error of dual energy X-ray absorptiometry (DXA) has been reported to be 425 g for whole-body fat and fat-free mass (35), with a correlation of 0.99 with a four-compartment model body composition method for measuring fat-free mass and 0.93-0.97 with multislice computed tomography for measuring regional fat-free mass (36). Whole-body DXA is recommended for determining body composition in children (37,38), and the coefficients of variation (CV) for lean body and fat mass by DXA in the pediatric weight range have been reported as 1.0 and 4.1% respectively (39,40).…”

Section: Subjectsmentioning

confidence: 99%

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Pacifico¹,

Anania²,

Osborn³

et al. 2008

European Journal of Endocrinology

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Background: Helicobacter pylori, and the chronic gastric inflammation that it causes, may compromise the function and survival of ghrelin-producing cells, resulting in a decrease of circulating ghrelin levels. This finding raises the possibility that the infection might affect growth in children by reducing the ghrelin production. Aims: To determine baseline circulating levels of ghrelin and leptin in prepubertal children with and without H. pylori infection and to evaluate the long-term effects of H. pylori eradication on circulating levels of ghrelin and leptin as well as on body composition. Patients: Thirty children with H. pylori-associated gastritis, 35 children with H. pylori-negative gastric mucosa, and 20 healthy controls were studied. Results: At baseline, while leptin levels were significantly lower in H. pylori-positive patients, ghrelin concentrations did not differ among the three study groups. However, a significant inverse correlation between ghrelin concentrations and histological severity of gastritis was found. Eradication of the organism was associated with a progressive decrease in ghrelin concentrations over baseline at both 6-and 12-month follow-ups. SDS-body mass index (BMI), lean and fat mass, as well as leptin concentrations, significantly increased over baseline at both follow-ups. Conclusions: In prepubertal children, serum ghrelin concentrations are inversely related to the severity of H. pylori-associated gastritis. In these youngsters, long-term eradication of H. pylori infection is associated with a significant increase in BMI, lean and fat mass along with a significant decrease in circulating ghrelin levels and an increase in leptin levels.

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Reference data for bone density and body composition measured with dual energy x ray absorptiometry in white children and young adults

Cited by 311 publications

References 44 publications

Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism

Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism

Cow's Milk Allergy and Bone Mineral Density in Prepubertal Children

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

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