Luliconazole, an alternative antifungal agent against Aspergillus terreus

Zargaran, Mahdis; Taghipour, Simin; Kiasat, Neda; Aboualigalehdari, Elham; Rezaei‐Matehkolaei, Ali; Mahmoudabadi, Ali Zarei; Shamsizadeh, Forough

doi:10.1016/j.mycmed.2017.04.011

Cited by 17 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…fumigatus isolates (0.001 to 0.008 μg/ml) (19). The reference ranges were generally lower than those of the other azoles tested, consistent with the findings for other Aspergillus species (18, 20). Olorofim (F901318) is an orotomide antifungal drug that has proven in vitro activity against filamentous fungi with high MIC values of commonly used antifungal drugs or demonstrated azole resistance, including Scedosporium , Lomentospora , and Aspergillus species (21, 22).…”

Section: Discussionsupporting

confidence: 86%

“…fumigatus and A. terreus isolates and in in vivo animal models has demonstrated that it is a promising treatment alternative to currently used antifungals, has much lower MIC values than other antifungals (azoles, echinocandins, and polyenes), and results in improved survival rates (18–20). All AVSC isolates had luliconazole MICs in the same range reported for azole-susceptible A.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex

Talbot

Frisvad

Meis

et al. 2019

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The past decade has seen an increase in aspergillosis in humans and animals due to Aspergillus viridinutans species complex members. Azole resistance is common to these infections, carrying a poor prognosis. cyp51A gene mutations are the main cause of acquired azole resistance in Aspergillus fumigatus. This study aimed to determine if the azole-resistant phenotype in A. viridinutans complex members is associated with cyp51A mutations or extrolite profiles.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex

Talbot

Frisvad

Meis

et al. 2019

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…The extracts were diluted in DMSO with the highest concentration in well 1 was 512 µg/mL, followed by dilution of ½ to obtain a decreasing range of concentrations. Add 50 µL test microorganism inocula; and 30 µL resazurin at 0.015 mg/mL as an indicator for cell viability; plates were incubated at 35 o C for 16-48 hours [29]. The MIC endpoints were observed visually when viable cells changed their colour from purple to pink [30].…”

Section: Microdilution Methodsmentioning

confidence: 99%

Myxobacteria From Vietnam: Isolation, Phylogenetic Analysis and Bioprospection

Nguyen

Duong

Nguyen

et al. 2022

Preprint

View full text Add to dashboard Cite

Forty-three myxobacterial strains were isolated and identified from 20 soil samples collected in Vietnam. The information on morphological characteristics and 16S ribosomal gene sequencing showed that these strains were designated to seven genera belonging to Angiococcus, Archangium, Chondromyces, Corallococcus, Cystobacter, Melittangium, and Myxococcus, in suborder Cystobacterineae and Sorangiineae. The phylogenetic tree was constructed to clarify the genetic relationship between myxobacterial isolates. Myxobacteria were cultured, and crude extracts were obtained after 10-day fermentation in P-medium in the presence of the Amberlite XAD 16N adsorbent resin. Elution was carried out with acetone and methanol to obtain the crude extracts. Evaluation of antioxidant activity used the DPPH and ABTS assay, the minimum inhibitory concentration values were determined by the microdilution method. The total extract from CT21 had the highest total antioxidant activity (IC50 = 52.34 +/- 1.47 mcg/mL, 30.28 +/- 0.74 mcg/mL for DPPH and ABTS assays, respectively). The other potential strain was TG131 and GL41 that IC50 values were 40.28 +/- 1.13 and 57.24 +/- 1.52 mcg/mL, respectively (by the DPPH method), and 48.35 +/- 0.58 and 42.76 +/- 0.50 mcg/mL, respectively (by the ABTS method). Interestingly, 100% isolated myxobacterial strains show inhibitory activity against at least one of the tested microorganisms. The potential antimicrobial strain was GL41, which inhibited all tested microorganisms, and the MIC values were 1 mcg/mL against MRSA, MSSA, S. faecalis, C. albicans, and A. niger. The highest active strains were members of Myxococcus sp. genus.

show abstract

“…Luliconazole initially available as topical cream (LUZU) 1% for dermatophytosis and solution 10% for onychomycosis (1,3,4). A very low minimum inhibitory concentration (MIC) of luliconazole for dermatophytes, Candida, Fusarium and Aspergillus species has been reported (2,(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

“…So that, voriconazole was presented as the first-line antifungal for invasive aspergillosis therapy (13,14). Also, caspofungin is recommended for invasive aspergillosis in AIDs patients (5). The clinical resistance of Aspergillus species to echinocandins like caspofungin is very low (15).…”

Section: Introductionmentioning

confidence: 99%

The high efficacy of luliconazole against environmental and otomycosis Aspergillus flavus strains

Moslem

Mahmoudabadi

2020

IJM

View full text Add to dashboard Cite

Background and Objectives: Luliconazole is currently confirmed for the topical therapy of dermatophytosis. Moreover, it is found that luliconazole has in vitro activity against some molds and yeast species. The aim of the present study was to evaluate the efficacy of luliconazole in comparison to routine used antifungals on clinical and environmental isolates of Aspergillus flavus. Materials and Methods: Thirty eight isolates of A. flavus (18 environmental and 20 clinical isolates) were detected based on morphological and microscopic features and also PCR-sequencing of β-tubulin ribosomal DNA gene. All the isolates were tested against luliconazole, voriconazole, amphotericin B and caspofungin. Minimum inhibitory concentration (MIC), 90 MIC50, MIC isolates. and MIC Geometric (GM) were calculated using CLSI M38-A2 protocol for both environmental and clinical GM Results: Luliconazole with extremely low MIC range, 0.00049-0.00781 μg/mL and MIC 0.00288 μg/mL showed very strong activity against both clinical and environmental A. flavus isolates. Moreover, voriconazole inhibited 100% of isolates at defined epidemiological cutoff values (ECV ≤ 2 µg/ml). 50% and 27.8% of clinical and environmental isolates of A. flavus, were resistant to caspofungin, respectively. Whereas, all the isolates were found to be resistant to amphotericin B. GM Conclusion: The analysis of our data clearly indicated that luliconazole (with MIC 0.00244 µg/ml for clinical and 0.00336 μg/ml for environmental isolates) had the highest in vitro activity against A. flavus strains.

show abstract

Luliconazole, an alternative antifungal agent against Aspergillus terreus

Cited by 17 publications

References 43 publications

cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex

cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex

Myxobacteria From Vietnam: Isolation, Phylogenetic Analysis and Bioprospection

The high efficacy of luliconazole against environmental and otomycosis Aspergillus flavus strains

Contact Info

Product

Resources

About