Luestertiärstadium der Mundhöhle

Kirwald, H.; Montag, Andreas

doi:10.1055/s-2007-996867

Cited by 8 publications

(2 citation statements)

References 5 publications

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“…Traumatic ulceration and squamous cell carcinoma might be quite similar to syphilitic chancre. Detailed history of sexual and social life style helps approach the diagnosis of primary syphilis [ 26 , 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree

Mortazavi

Safi

Baharvand

et al. 2016

International Journal of Dentistry

124

122

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Diagnosis of oral ulcerative lesions might be quite challenging. This narrative review article aims to introduce an updated decision tree for diagnosing oral ulcerative lesions on the basis of their diagnostic features. Various general search engines and specialized databases including PubMed, PubMed Central, Medline Plus, EBSCO, Science Direct, Scopus, Embase, and authenticated textbooks were used to find relevant topics by means of MeSH keywords such as “oral ulcer,” “stomatitis,” and “mouth diseases.” Thereafter, English-language articles published since 1983 to 2015 in both medical and dental journals including reviews, meta-analyses, original papers, and case reports were appraised. Upon compilation of the relevant data, oral ulcerative lesions were categorized into three major groups: acute, chronic, and recurrent ulcers and into five subgroups: solitary acute, multiple acute, solitary chronic, multiple chronic, and solitary/multiple recurrent, based on the number and duration of lesions. In total, 29 entities were organized in the form of a decision tree in order to help clinicians establish a logical diagnosis by stepwise progression.

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Section: Resultsmentioning

confidence: 99%

Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree

Mortazavi

Safi

Baharvand

et al. 2016

International Journal of Dentistry

124

122

View full text Add to dashboard Cite

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“…[17,18,24] The clemizole-penicillin combination was widely employed for treating syphilis. [25][26][27] Nowadays, clemizole becomes popular again with not only its antihistaminic features but also the blocking effects of TRPC5 cation channels, specifically. On the other hand, Cis is widely used in the treatment of several malignancies as an antitumoral drug.…”

Section: Discussionmentioning

confidence: 99%

Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin‐induced nephrotoxicity in Spraque–Dawley rats

Kumaş

Gepdíremen

Karataş

et al. 2023

J Biochem & Molecular Tox

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Cis‐diamminedichloroplatinum (II) (cisplatin, Cis) is widely employed to treat several types of cancer. It has many important toxic side effects; one of the most important of which is nephrotoxicity. Clemizole hydrochloride (Clem) as the most potent inhibitor of TRPC5 channels was tested in an animal model of Cis‐induced nephrotoxicity. Rats were divided into the following groups: control; Cis (8 mg/kg); Cis + 1 mg/kg Clem; Cis + 5 mg/kg Clem; Cis + 10 mg/kg Clem. Kidney injury was detected by histopathological and biochemical analysis. Urine urea nitrogen (UUN), creatinine, urine neutrophil gelatinase‐associated lipocalin (NGAL), serum catalase (CAT), and malondialdehyde (MDA) levels were determined by enzyme‐linked immunosorbent assay. Total antioxidant status (TAS) and total oxidant status (TOS) were studied using a colorimetric assay. Nephrin, synaptopodin, and Rac family small GTPase 1 (RAC1) expressions were detected by Western blot analysis. Cis was found to induce histopathological alterations, including tubular degeneration, congestion, hemorrhage, hyaline casts, glomerular collapse, and apoptotic cell death. Clem at a dose of 1 and 5 mg/kg attenuated histopathological alterations. UUN, creatinine, and NGAL levels increased in the Cis‐administered group, while all doses of Clem decreased in those. CAT and TAS levels decreased, while TOS and oxidative stress index levels increased in the Cis‐treated group. A dose of 1 and 5 mg Clem showed antioxidant effects against oxidative stress. Cis induced lipid peroxidation by increasing MDA levels. All doses of Clem reduced MDA levels. Nephrin and synaptopodin expressions were decreased by Cis, and all doses of Clem increased that. All doses of Clem successfully depressed RAC1 expression. Clem showed a highly ameliorating effect on toxicity caused by Cis by blocking TRPC5 calcium channels.

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