Burning-mouth-Syndrom

Burning mouth syndrome: the efficacy of lipoic acid on subgroups

“…BMS is not a specific disease entity but rather it is the manifestation of a range of aetiologies 23,24 and, for the treating clinician, it has remained an enigma because defined pathological lesions or processes are usually not evident 25 . Thus, unsurprisingly, current treatments are not reliably effective 26 . We have previously shown that alpha‐lipoic acid (ALA; Tiobec), a potent antioxidant mitochondrial coenzyme, the trometamol salt of thioctic acid, essential for various reactions of the Krebs cycle and glycolysis, regenerating, through the oxidation–reduction cycle, other antioxidants such as vitamin C and E, increasing the level of intracellular glutathione, and stimulating the production of ‘nerve‐growth factors’, 27 can be effective in some patients with BMS 20,21 …”

“…25 Thus, unsurprisingly, current treatments are not reliably effective. 26 We have previously shown that alpha-lipoic acid (ALA; Tiobec), a potent antioxidant mitochondrial coenzyme, the trometamol salt of thioctic acid, essential for various reactions of the Krebs cycle and glycolysis, regenerating, through the oxidation-reduction cycle, other antioxidants such as vitamin C and E, increasing the level of intracellular glutathione, and stimulating the production of 'nerve-growth factors' , 27 can be effective in some patients with BMS. 20,21 In the present study, patients with BMS who were treated with tranquillizers (group A), though somewhat older, responded poorly to therapy with lipoic acid compared with those who had not received previous psychotropic therapy (group B).…”