Lubrication in tablet formulations

Wang, Jennifer; Wen, Hu; Desai, Divyakant

doi:10.1016/j.ejpb.2010.01.007

Cited by 215 publications

(88 citation statements)

References 59 publications

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“…This chemical is a widely used lubricant for tablet compression because of its expedient mechanical properties: low coefficient of friction, very small particles and hydrophobic properties (Wang et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

“…With the market share of 6% in the world, it is one of the major components in the formulation of food products. Starch is one of the most widely used excipients in manufacture of solid dosage form as binder and dissenter in tablets formulation (Ahmad et al, 2012;Odeku et al, 2005;Ruppel et al, 2009;Wang et al, 2010). Starch is a useful raw material for biodegradable thermoplastics because of its natural abundance and low cost (Mitrus and Mościcki, 2009;Mościcki et al, 2012;Zavareze et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Magnesium stearate is widely used in tablet formulation because of its lubrication action and ability to form hydrophobic thin film on the surface of the carrier granules. Use of magnesium stearate allows to reduce power consumption and ejection forces in tablet production (Wang et al, 2010). Another factor determining the mechanical behaviour of powders is moisture content that affects flowability, cohesion, caking, density, shear strength, compaction and compression characteristics (Nokhodchi, 2005).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mechanical properties of potato starch modified by moisture content and addition of lubricant

Stasiak¹,

Molenda²,

Horabik³

et al. 2014

International Agrophysics

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A b s t r a c t. Laboratory testing was conducted to deliver a set of characteristics of structure and mechanical properties of pure starch and starch with an addition of a lubricant -magnesium stearate. Considerable influence of moisture content of potato starch was found in the case of density, parameters of internal friction, coefficients of wall friction and flowability. Elasticity was found to be strongly influenced by water content of the material. Addition of magnesium stearate affected density and parameters of flowability, internal friction and elasticity. Bulk density increased from 604 to 774 kg m -3 with decrease in moisture content of potato starch from 17 to for 6%. Addition of magnesium stearate resulted in approximately 10% decrease in bulk density. Angle of internal friction obtained for 10 kPa of consolidation stress decreased from 33 to 24º with increase in moisture content, and to approximately 22º with addition of the lubricant. With an increase of moisture content from 6 to 18% and with addition of the lubricant, the modulus of elasticity during loading decreased from approximately 1.0 to 0.1 MPa. Modulus of elasticity during unloading was found in the range from 19 to 42 MPa and increased with increase of moisture content and amount of lubricant.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mechanical properties of potato starch modified by moisture content and addition of lubricant

Stasiak¹,

Molenda²,

Horabik³

et al. 2014

International Agrophysics

View full text Add to dashboard Cite

show abstract

“…Lately, due to the development of instrumentations in surface and interfacial characterization, and force measurements as well as the improved understanding between friction and adhesion force, tribology has been developed into an active research field. In particular, in the pharmaceutical industry, the application of lubrication or tribology in drug development has become increasingly important for developing a successful manufacturing process [2].…”

Section: Introductionmentioning

confidence: 99%

“…As their names implies, the former three mechanisms are related to the usage of liquid lubricants to some extent. In the pharmaceutical industry, boundary lubrication is the most common mechanism functioning in unit operations [2]. For boundary lubrication, a lubricant typically forms layers/film between surfaces or at interfaces to reduce friction, where the penetration of the lubricant into surface asperities occurs.…”

Section: Lubricationmentioning

confidence: 99%

Lubricants in Pharmaceutical Solid Dosage Forms

2014

Lubricants

175

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Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing operations are caused by issues related to lubrication, in general, lubricants do not gain adequate attention in the development of pharmaceutical formulations. In this paper, the fundamental background on lubrication is introduced, in which the relationships between lubrication and friction/adhesion forces are discussed. Then, the application of lubrication in the development of pharmaceutical products and manufacturing processes is discussed with an emphasis on magnesium stearate. In particular, the effect of its hydration state (anhydrate, monohydrate, dihydrate, and trihydrate) and its powder characteristics on lubrication efficiency, as well as product and process performance is summarized. In addition, the impact of lubrication on the dynamics of compaction/compression processes and on the mechanical properties of compacts/tablets is presented. Furthermore, the online monitoring of magnesium stearate in a blending process is briefly mentioned. Finally, the chemical compatibility of active pharmaceutical ingredient (API) with magnesium stearate and its reactive impurities is reviewed with examples from the literature illustrating the various reaction mechanisms involved.

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Excipients for Conventional Oral Solid Dosage Forms

Kestur

Desai

2016

Pharmaceutical Excipients

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Lubrication in tablet formulations

Cited by 215 publications

References 59 publications

Mechanical properties of potato starch modified by moisture content and addition of lubricant

Mechanical properties of potato starch modified by moisture content and addition of lubricant

Lubricants in Pharmaceutical Solid Dosage Forms

Excipients for Conventional Oral Solid Dosage Forms

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