Lubricant‐Infused Polymeric Interfaces: A Stretchable and Anti‐Fouling Surface for Implantable Biomaterials

Abstract

Developing thin, highly stretchable coatings that inhibit the undesirable adhesion of biological substances on soft and high‐water‐content biomaterial surfaces is an area of significant interest. In this study, a stretchable antifouling coating named lubricant‐infused poly(1,3,5,7‐tetramethyl‐1,3,5,7‐tetravinyl cyclotetrasiloxane) (V4D4) is introduced interface with perfluoropolymer (L‐VIP). The stretchable adhesive‐perfluoropolymer bilayer comprises stretchable adhesive polymer (V4D4) and perfluoropolymer (1H,1H,2H,2H‐perfluorooctyl methacrylate (FOMA)). The bilayer exhibits a strong affinity with the lubricant, imparting exceptional antifouling and slippery properties. L‐VIP coating displays superior fouling resistance against plasma proteins related to foreign body reactions (FBR) and biofilm‐forming bacteria. The coating exhibits impressive elastic limits exceeding 200% strain and exceptional stability under repeated cyclic stretching (> 2000 cycles at 150% strain) while maintaining its antifouling properties. Furthermore, the coating presents dielectric performance under accelerated aging conditions at a temperature of 70° and constant voltage stress of 10 V s−1 for over 50 days. To assess the biocompatibility of the L‐VIP coating, a series of in vitro and in vivo experiments are conducted, confirming its non‐toxicity for biomedical applications. It is expected that the stretchable L‐VIP coating will enhance medical devices’ longevity and help prevent bacterial infections, the formation of biofilms, and the nonspecific adherence of biological substances after implantation.

Hydrogel/MOF Dual-Modified Photoelectrochemical Biosensor for Antibiofouling and Biocompatible Dopamine Detection

“…Furthermore, to meet the long-term antibiofouling demands of practical biosensing applications, various hydrophilic polymers have been developed as anticontamination materials. , However, these methods often encounter limitations, such as complex synthesis processes and poor conductivity of the modified layers, affecting electrode sensing sensitivity. In recent years, hydrogel networks composed of three-dimensional cross-linked hydrophilic polymers have garnered widespread attention for their applications in chemical and biological sensing. − Hydrogels possess a high water content, excellent flexibility, biocompatibility, and ease of synthesis.…”