LTP of AMPA and NMDA Receptor–Mediated Signals: Evidence for Presynaptic Expression and Extrasynaptic Glutamate Spill-Over

Kullmann, Dimitri M.; Erdemli, Gül; Asztély, Fredrik

doi:10.1016/s0896-6273(00)80178-6

Cited by 254 publications

(192 citation statements)

References 53 publications

Supporting

Mentioning

181

Contrasting

Unclassified

Order By: Relevance

“…(C and D) When change in PPF is calculated using points ''b'' and ''c,'' there is a significant correlation between change in PPF and LTP (C, r ϭ 0.87, n ϭ 10, P Ͻ 0.005, linear regression shown) that is similar to that of the control data (D, E, data from C superimposed). different paradigm, an increase in p with LTP was also recently demonstrated by examining MK-801 occlusion of NMDA receptors in naive slices vs. after LTP induction (49).…”

Section: Discussionmentioning

confidence: 66%

Long-term potentiation involves increases in the probability of neurotransmitter release

Schulz

1997

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Biochemistry. In the article ''Identification by mass spectrometry of the phosphorylated residue responsible for activation of the catalytic domain of myosin I heavy chain kinase, a member of the PAK͞STE20 family'' by Joanna Szczepanowska, Xiaolong Zhang, Christopher J. Herring, Jun Qin, Edward D. Korn, and Hanna Brzeska, which appeared in number 16, August 5, 1997, of Proc. Natl. Acad. Sci. USA (94,(8503)(8504)(8505)(8506)(8507)(8508), the authors wish to note that in Fig. 3, the ions of m͞z 1345.3 and 1247.1 were incorrectly identified as b 13 and b 13 ⌬ , respectively, produced by cleavage of the peptide AS(Pi)VVGTTYW-MAPEVVK between E and V (Fig. 3 Inset). In fact, these ions are b 12 and b 12 ⌬ , produced by cleavage of the peptide between P and E. This correction has no effect on the conclusion that the phosphorylated residue is serine. Also, in Table 2, reference numbers 22-24 should be 21-23 (the reference in the legend is cited correctly) and the MIHCK sequence is from residue 624 to residue 638.Cell Biology. In the article ''Subtraction hybridization identifies a transformation progression-associated gene PEG-3 with sequence homology to a growth arrest and DNA damageinducible gene'' by Zao

show abstract

Section: Discussionmentioning

confidence: 66%

Long-term potentiation involves increases in the probability of neurotransmitter release

Schulz

1997

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…The enhanced neurotransmitter release at vertical intracortical connections after global sensory deprivation appears to be unique to adult sensory cortices, because global reductions in sensory activity in the developing somatosensory or visual cortices fail to modify neurotransmitter release (Finnerty and Connors, 2000;Philpot et al, 2001a). The deprivation-induced increase in release probability in the adult cortex enhances the likelihood that perisynaptic/extrasynaptic NMDARs may be activated by glutamate spillover (Kullmann et al, 1996), and future studies will be needed to investigate whether this spillover could be augmented by a decrease in glutamate reuptake (Shen and Linden, 2005). Nonetheless, our data are consistent with the idea that visual deprivation increases a perisynaptic/extrasynaptic population of ifenprodil-sensitive NMDARs that can be activated by glutamate spillover during bursts of high-frequency stimulation.…”

Section: Discussionmentioning

confidence: 99%

Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex

Yashiro¹,

Corlew²,

Philpot

2005

J. Neurosci.

View full text Add to dashboard Cite

Use-dependent modifications of synapses have been well described in the developing visual cortex, but the ability for experience to modify synapses in the adult visual cortex is poorly understood. We found that 10 d of late-onset visual deprivation modifies both presynaptic and postsynaptic elements at the layer 432/3 connection in the visual cortex of adult mice, and these changes differ from those observed in juveniles. Although visual deprivation in juvenile mice modifies the subunit composition and increases the current duration of synaptic NMDA receptors (NMDARs), no such effect is observed at synapses between layer 4 and layer 2/3 pyramidal neurons in adult mice. Surprisingly, visual deprivation in adult mice enhances the temporal summation of NMDAR-mediated currents induced by bursts of high-frequency stimulation. The enhanced temporal summation of NMDAR-mediated currents in deprived cortex could not be explained by a reduction in the rate of synaptic depression, because our data indicate that late-onset visual deprivation actually increases the rate of synaptic depression. Biochemical and electrophysiological evidence instead suggest that the enhanced temporal summation in adult mice could be accounted for by a change in the molecular composition of NMDARs at perisynaptic/extrasynaptic sites. Our data demonstrate that the experience-dependent modifications observed in the adult visual cortex are different from those observed during development. These differences may help to explain the unique consequences of sensory deprivation on plasticity in the developing versus mature cortex.

show abstract

“…Alternatively, it could represent a difference of expression in the transporter subtypes. GAT-3 expression has been reported to be low in the adult and may be developmentally regulated (Liu et al 1993;Minelli et al 1996), whereas GAT-1 expression is reported to be higher in the adult than the neonate (Yan et al 1997). Recordings in this study were made on animals primarily over the age of 15 days old, but Ͻ26 (19.39 Ϯ 0.46; n ϭ 146).…”

Section: Transporter Expressionmentioning

confidence: 99%

Synaptically Evoked GABA Transporter Currents in Neocortical Glia

Kinney

Spain

2002

Journal of Neurophysiology

View full text Add to dashboard Cite

. The presence, magnitude, and time course of GABA transporter currents were investigated in electrophysiologically characterized neocortical astrocytes in an in vitro slice preparation. On stimulation with a bipolar-tungsten stimulating electrode placed nearby, the majority of cells tested displayed long-lasting GABA transporter currents using both single and repetitive stimulation protocols. Using subtype-specific GABA transporter antagonists, long-lasting GABA transporter currents were identified in neocortical astrocytes that originated from at least two subtypes of GABA transporters: GAT-1 and GAT-2/3. These transporter currents displayed slow rise times and long decay times, contrasting the time course observed for glutamate transporter currents, and are indicative of a long extracellular time course of GABA as well as a role for glial GABA transporters during synaptic transmission.

show abstract

LTP of AMPA and NMDA Receptor–Mediated Signals: Evidence for Presynaptic Expression and Extrasynaptic Glutamate Spill-Over

Cited by 254 publications

References 53 publications

Long-term potentiation involves increases in the probability of neurotransmitter release

Long-term potentiation involves increases in the probability of neurotransmitter release

Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex

Synaptically Evoked GABA Transporter Currents in Neocortical Glia

Contact Info

Product

Resources

About