&lt;title&gt;Photodynamic therapy of cancer: five-year clinical experience&lt;/title&gt;

Stranadko, Eugeny Ph.; Skobelkin, Oleg K.; Vorozhtsov, Georgy N.; Mironov, A. F.; Beshleul, Stanislav E.; Markitchev, Nikolai A.; Riabov, Michail V.

doi:10.1117/12.297812

Cited by 10 publications

(6 citation statements)

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“…The phthalocyanines and naphthalocyanines which can be synthesised by currently available methods have been sufficient to show the potential of these systems as PDT agents, not only in oncological applications [66] but also as photovirucides in the sterilisation of blood products [78]. Nevertheless it would be useful, both here and in electroactive materials applications, to have more flexible stepwise syntheses to hand, such as exist in the related porphyrin chemistry.…”

Section: Phthalocyanines and Naphthalocyaninesmentioning

confidence: 98%

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Progress with heterocyclic photosensitizers for the photodynamic therapy (PDT) of tumours

Bonnett

2002

Journal of Heterocyclic Chem

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Section: Phthalocyanines and Naphthalocyaninesmentioning

confidence: 98%

“…The mixture is complex, but components can be separated by HPLC [65]. Under the trade name "Photosens" this mixture, thought to be mainly a mixture of the di and tri sulphonic acids 43, has been in clinical use in Russia for the treatment of cancer by PDT for some years [66].…”

Section: Phthalocyanines and Naphthalocyaninesmentioning

confidence: 99%

Progress with heterocyclic photosensitizers for the photodynamic therapy (PDT) of tumours

Bonnett

2002

Journal of Heterocyclic Chem

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“…In 1990 Photochem , another photosensitizer derived from haematoporphyrin was developed at the Lomonosov Moscow State Academy of Fine Chemical Technology by Mironov et al [ 135 , 136 , 137 , 138 , 139 ]. This potosensitizer was clinically tested from 1992 to 1996 then showing complete tumor resolution in 92% of the patients.…”

Section: Crossed and Linked Histories Of Tetrapyrrolic Or How Natumentioning

confidence: 99%

“…In 1994 a research group headed by Vorozhtsov [ 139 , 142 , 143 , 144 ] developed at NIOPIK , a Moscow Research and Production Association, the second generation of photosensitizers [ 142 , 143 , 144 , 145 ], consisting of water solutions of sodium salts of aluminum di- to tetra-sulfonated phthalocyanine (another member of the tetrapyrrolic macrocycles) named Photosense [ 142 , 143 ]. These solutions have strong absorption in the red region of the spectrum with a maximum at 675 nm and a Soret band at 350 nm.…”

Section: Crossed and Linked Histories Of Tetrapyrrolic Or How Natumentioning

confidence: 99%

Crossed and Linked Histories of Tetrapyrrolic Macrocycles and Their Use for Engineering Pores within Sol-Gel Matrices

et al. 2013

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The crossed and linked histories of tetrapyrrolic macrocycles, interwoven with new research discoveries, suggest that Nature has found in these structures a way to ensure the continuity of life. For diverse applications porphyrins or phthalocyanines must be trapped inside solid networks, but due to their nature, these compounds cannot be introduced by thermal diffusion; the sol-gel method makes possible this insertion through a soft chemical process. The methodologies for trapping or bonding macrocycles inside pristine or organo-modified silica or inside ZrO2 xerogels were developed by using phthalocyanines and porphyrins as molecular probes. The sizes of the pores formed depend on the structure, the cation nature, and the identities and positions of peripheral substituents of the macrocycle. The interactions of the macrocyclic molecule and surface Si-OH groups inhibit the efficient displaying of the macrocycle properties and to avoid this undesirable event, strategies such as situating the macrocycle far from the pore walls or to exchange the Si-OH species by alkyl or aryl groups have been proposed. Spectroscopic properties are better preserved when long unions are established between the macrocycle and the pore walls, or when oligomeric macrocyclic species are trapped inside each pore. When macrocycles are trapped inside organo-modified silica, their properties result similar to those displayed in solution and their intensities depend on the length of the alkyl chain attached to the matrix. These results support the prospect of tuning up the pore size, surface area, and polarity inside the pore cavities in order to prepare efficient catalytic, optical, sensoring, and medical systems. The most important feature is that research would confirm again that tetrapyrrolic macrocycles can help in the development of the authentic pore engineering in materials science.

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“…Одним из таких дополнительных методов является фотодинамическая терапия (ФДТ). Описаны единичные клинические случаи применения ФДТ в лечении колоректального рака, рандомизированные контролируемые исследования не проводились [4][5][6][7][8][9][10]. Анализ исследований в соответствии с протоколом PRISMA выполнен в систематическом обзоре, недавно зарегистрированном в международном реестре [11].…”

Section: Introductionunclassified

Outcomes after intraoperative photodynamic therapy in the combined treatment of locally advanced colon cancer

Krochek,

Ibatullin,

Lappa

et al. 2023

Lazernaâ medicina

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Purpose. To study outcomes after the combined treatment of locally advanced colon cancer with intraoperative photodynamic therapy. Materials and methods. 35 patients with locally advanced colon cancer were included in the trial. Patients from the main group (n = 17) had intraoperative photodynamic therapy in combination with elective surgery. Patients from the control group (n = 18) had only surgical treatment. For photodynamic therapy, photosensitizer Photolon and “Lakhta-Milon” diode laser with wavelength 662 nm and power up to 2.5 W were used. Laser light was delivered via a quartz polymer fiber with diameter 600 microns. Results and discussion. Better positive immediate and long-term outcomes were registered in patients with locally advanced colon cancer from the main group, if to compare with the control group (length of hospital stay, number of remissions, relapses and mortality). Conclusion: Intraoperative photodynamic therapy improves outcomes after the combined treatment of patients with locally advanced colon cancer.

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<title>Photodynamic therapy of cancer: five-year clinical experience</title>

Cited by 10 publications

References 0 publications

Progress with heterocyclic photosensitizers for the photodynamic therapy (PDT) of tumours

Progress with heterocyclic photosensitizers for the photodynamic therapy (PDT) of tumours

Crossed and Linked Histories of Tetrapyrrolic Macrocycles and Their Use for Engineering Pores within Sol-Gel Matrices

Outcomes after intraoperative photodynamic therapy in the combined treatment of locally advanced colon cancer

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