&lt;title&gt;Objective measurements of haze following phototherapeutic excimer laser ablation of cornea&lt;/title&gt;

McCally, Russell L.; Connolly, Patrick J.; Jain, Sandeep; Azar, Dimitri T.

doi:10.1117/12.178552

Cited by 8 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Corneal haze can be recorded subjectively by observation with a slit-lamp, although more objective methods have been described. Clinical instruments for measurement of haze have included custom modified slit-lamps, 3 , 5 , 6 clinical confocal microscopes, 2 , 7 and Scheimpflug cameras. 8 – 19 Spatial resolution needed to identify the source of the backscattered light varies among instruments.…”

mentioning

confidence: 99%

Measuring Corneal Haze by Using Scheimpflug Photography and Confocal Microscopy

McLaren

Wacker

Kane

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PurposeWe compared corneal backscatter estimated from a Scheimpflug camera with backscatter estimated from a clinical confocal microscope across a wide range of corneal haze.MethodsA total of 59 corneas from 35 patients with a range of severity of Fuchs' endothelial corneal dystrophy and 15 corneas from 9 normal participants were examined using a Scheimpflug camera (Pentacam) and a confocal microscope (ConfoScan 4). The mean image brightness from the anterior 120 μm, midcornea, and posterior 60 μm of the cornea across the central 2 mm recorded by the Scheimpflug camera and analogous regions from the confocal microscope were measured and standardized. Differences between instruments and correlations between backscatter and disease severity were determined by using generalized estimating equation models.ResultsBackscatter measured by the two instruments in the anterior and midcornea were correlated (r = 0.67 and 0.43, respectively, P < 0.001), although in the posterior cornea they were not correlated (r = 0.13, P = 0.66). Measured with the Scheimpflug camera, mean backscatter from the anterior and midcornea were greater, whereas backscatter from the posterior cornea was lower (P < 0.001) than that measured by the confocal microscope. Backscatter from the anterior cornea was correlated with disease severity for both instruments (Scheimpflug, r = 0.55, P < 0.001; confocal, r = 0.49, P = 0.003).ConclusionsThe Scheimpflug camera and confocal microscope should not be used interchangeably to measure corneal haze. The ability to detect changes in backscatter with disease severity is superior with the Scheimpflug camera. However, the confocal microscope provides higher resolution of corneal structure.

show abstract

mentioning

confidence: 99%

Measuring Corneal Haze by Using Scheimpflug Photography and Confocal Microscopy

McLaren

Wacker

Kane

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…The small amount of scattered light produced by this tissue has in particular been extensively researched in the literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. All previous theories explaining corneal transparency [21][22][23][24][25][26][27] have focused on light propagation in the stromal extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

“…They can be caused by microstructural alterations, the irregular organization of the extracellular matrix, or by cells [22]. Many studies have attempted to relate form, density, and cell size to the structure of the scattered light [1][2][3][4][5][6][7]17,18]. Mourant et al [12,13] suggest that the cell itself is responsible for scattering at a small angle.…”

Section: Introductionmentioning

confidence: 99%

Measurement of correlation between transmission and scattering during wound healing in hen corneas

Mar

Martínez-García

Blanco–Mezquita

et al. 2009

Journal of Modern Optics

View full text Add to dashboard Cite

The aim of this work is to provide experimental data for corneal transparency and scattering to help create a more complete model of corneal transparency. The scattered light in 96 healing hen corneas was measured for three wavelengths by a scatterometer constructed in the Optics Laboratory (The University of Valladolid, Spain). With the help of mirrors and beamsplitters, the light from the three lasers is directed toward the cell containing the sample to be measured. The measured scattered light varies between six orders of magnitude. Corneal transmissivity, mean cosine of a scattering angle, and angular distribution of scattered light were all computed. The total transmitted light remained practically constant over a wide range of light values transmitted in a forward direction (direct transmissivity). The value of the mean cosine of the scattering direction is very close to the unit (g 4 0:98), even in corneas with high opacities. The behavior of g indicates that even damaged corneas evidence extremely small scattering, compared to other biological tissues. The transmission reduction of each cornea is related to an increase in scattered light. In all cases, scattered light is concentrated at very small angles. This behavior is acceptable in corneas that are healthy or which evidence small lesions, but remains in corneas that are severely injured.

show abstract

“…Slit lamp imaging has been used to clinically estimate corneal haze manually by physicians but not automatically. For example, it was used to observe the cornea haze after excimer laser ablation of cornea [ 286 , 287 ]. Slit lamp suffers from resolution reduction caused by interference of light reflected from structures above and below the plane of examination.…”

Section: Appendixmentioning

confidence: 99%

A survey on computer aided diagnosis for ocular diseases

Zhang

Srivastava

Liu

et al. 2014

BMC Med Inform Decis Mak

View full text Add to dashboard Cite

BackgroundComputer Aided Diagnosis (CAD), which can automate the detection process for ocular diseases, has attracted extensive attention from clinicians and researchers alike. It not only alleviates the burden on the clinicians by providing objective opinion with valuable insights, but also offers early detection and easy access for patients.MethodWe review ocular CAD methodologies for various data types. For each data type, we investigate the databases and the algorithms to detect different ocular diseases. Their advantages and shortcomings are analyzed and discussed.ResultWe have studied three types of data (i.e., clinical, genetic and imaging) that have been commonly used in existing methods for CAD. The recent developments in methods used in CAD of ocular diseases (such as Diabetic Retinopathy, Glaucoma, Age-related Macular Degeneration and Pathological Myopia) are investigated and summarized comprehensively.ConclusionWhile CAD for ocular diseases has shown considerable progress over the past years, the clinical importance of fully automatic CAD systems which are able to embed clinical knowledge and integrate heterogeneous data sources still show great potential for future breakthrough.

show abstract

<title>Objective measurements of haze following phototherapeutic excimer laser ablation of cornea</title>

Cited by 8 publications

References 0 publications

Measuring Corneal Haze by Using Scheimpflug Photography and Confocal Microscopy

Measuring Corneal Haze by Using Scheimpflug Photography and Confocal Microscopy

Measurement of correlation between transmission and scattering during wound healing in hen corneas

A survey on computer aided diagnosis for ocular diseases

Contact Info

Product

Resources

About