&lt;title&gt;Nano-aerosol approach for characterization of proteins and viruses&lt;/title&gt;

Szymanski, Wladyslaw W.; Bacher, Gerold; Allmaier, Günter

doi:10.1117/12.454586

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the assessment of the possible internal composition of NPs (i.e., the number of modified dextran chains that participated in the formation of a single NP) aerosol technology methods were employed [ 15 – 17 ]. Dex-NPs were dispersed in an electrically conductive liquid and transferred to the aerosol phase by electrostatic atomization [ 18 , 19 ] by means of a nanoelectrospray generator (TSI Inc., Mod.…”

Section: Methodsmentioning

confidence: 99%

Dextran Nanoparticle Synthesis and Properties

et al. 2016

Self Cite

View full text Add to dashboard Cite

Dextran is widely exploited in medical products and as a component of drug-delivering nanoparticles (NPs). Here, we tested whether dextran can serve as the main substrate of NPs and form a stable backbone. We tested dextrans with several molecular masses under several synthesis conditions to optimize NP stability. The analysis of the obtained nanoparticles showed that dextran NPs that were synthesized from 70 kDa dextran with a 5% degree of oxidation of the polysaccharide chain and 50% substitution with dodecylamine formed a NP backbone composed of modified dextran subunits, the mean diameter of which in an aqueous environment was around 100 nm. Dextran NPs could be stored in a dry state and reassembled in water. Moreover, we found that different chemical moieties (e.g., drugs such as doxorubicin) can be attached to the dextran NPs via a pH-dependent bond that allows release of the drug with lowering pH. We conclude that dextran NPs are a promising nano drug carrier.

show abstract