&lt;title&gt;Measurements of the optical properties of breast tissue using time-resolved transillumination&lt;/title&gt;

Koelzer, Jochen G.; Mitic, G.; Otto, J.

doi:10.1117/12.200841

Cited by 17 publications

(12 citation statements)

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“…This could be consistent with the above-mentioned different boundary conditions of the anteromedial position as well as with the anatomy of the female breast: the lateral and medial positions have a higher content of adipose tissue, whereas glandular tissue dominates at the anteromedial position. Consistent with our previous in vitro results 1 and with the investigations of Key et al, 8 we nevertheless assume that adipose tissue shows a greater reduced scattering coefficient than glandular tissue. This conclusion should be verified by statistically more significant measurements.…”

Section: Time Resolved and Spectroscopic Studies Of The Breastsupporting

confidence: 88%

“…[1][2][3][4][5] In the first part, the time-resolved in vivo measurements for determining the optical properties of breast tissue are described. [1][2][3] In the second part, spectral in vivo measurements obtained by transilluminating the breasts of volunteers 4,5 and patients 5 in the diagnostic window (650 to 1000 nm) are presented. Important information about the wavelength-dependent transmission characteristics of benign and malignant lesions may be obtained in this way.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of female breasts in vivo by time-resolved and spectroscopic measurements in the near infrared spectroscopy

1996

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Time-resolved and spectroscopic in vivo measurements were performed to determine the optical properties of the female breast in transmission. The time-resolved measurements were carried out at different positions on the female breast with a Ti:sapphire laser (800 nm) using a synchroscan streak camera. A diffusion model was used to calculate the absorption coefficient A and the reduced scattering coefficient. In addition, spectroscopic in vivo measurements of more than 100 patients were performed in a wavelength range between 650 and 1000 nm. A variety of pathological alterations could be characterized by measuring patients of different ages, different breast sizes, and at varying locations on the breast. The results indicate that besides the pure detection of the amount of blood in the neovascular network, the volume concentrations of water and fat seem to be of particular importance for discrimination. In order to quantify this observation, an analytical model was developed that takes the volume percentages of fat and water, the concentration and oxygenation of hemoglobin, and the relevant optical parameters into account. Experiments were carried out with volunteers and patients in a clinical environment: Typical observations are presented and analyzed statistically.

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Section: Time Resolved and Spectroscopic Studies Of The Breastsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Characterization of female breasts in vivo by time-resolved and spectroscopic measurements in the near infrared spectroscopy

1996

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“…16 This slow decay rate confirms that TRUE optical focusing is capable of suppressing the medium's turbidity by converging multiply scattered photons, instead of ballistic photons, back into the encoded region inside a tissue sample. A maximum penetration depth of 5 mm, Fig.…”

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confidence: 53%

Time-reversed ultrasonically encoded optical focusing in biological tissue

Lai¹,

Xu²,

Liu³

et al. 2012

J. Biomed. Opt.

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“…To make the phantoms with a height of 10 cm and a diameter of73 cm, we used water (500 ml) (= O15 cm' at X = 1064 nm), gelatin (105 g), and low fat milk (100 ml). This concentration of milk was chosen to provide effective attenuation coefficient, of 12 cm1, which is similar to that of normal breast tissue in vivo [6,7]. Absorbing volumes simulating tumors were made of the same optically turbid gel and colored either with Naphtol Green B or bovine hemoglobin.…”

Section: Phantomsmentioning

confidence: 99%

“…The absorption coefficient of blood is about 5 cm' at X = 1064 nm [5,6], while background absorption of normal breast tissue is only 0.03 -0.05 cm1 [7,8]. Optical tomography has a potential for breast cancer detection.…”

Section: Introductionmentioning

confidence: 99%

Comparison of optoacoustic tomography with ultrasound and x-ray imaging for breast cancer detection

et al. 2001

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This paper is devoted to comparison new optoacoustic tomography with conventional breast tumors diagnostic techniques such as ultrasonography and X-ray radiography. Experiments were performed in phantoms simulating breast with tumors. The fundamental harmonic of Q-switched Nd:YAG laser (2 = 1064 nm) was used to generate optoacoustic pressure waves. Laser induced pressure waves were detected by a wide-band acoustic transducer. Digital oscilloscope controlled by PC was used to store and process optoacoustic signals. Gelatin phantoms with controlled optical parameters were prepared to simulate breast with tumors. Absorbing volumes colored with naphthol green and hemoglobin were embedded in the gelatin phantoms to model the breast tumors with increased optical absorption. Optoacoustic pressure waves from the phantoms were detected at different angles and 2D images were reconstructed. Comparison of optoacoustic images with images obtained with ultrasound and X-ray techniques proved that optoacoustic method has substantially higher contrast and resolution. Obtained results confirm that laser optoacoustic imaging technique can be an important tool for early breast cancer detection with tumors less than 5 mm in diameter.

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<title>Measurements of the optical properties of breast tissue using time-resolved transillumination</title>

Cited by 17 publications

References 0 publications

Characterization of female breasts in vivo by time-resolved and spectroscopic measurements in the near infrared spectroscopy

Characterization of female breasts in vivo by time-resolved and spectroscopic measurements in the near infrared spectroscopy

Time-reversed ultrasonically encoded optical focusing in biological tissue

Comparison of optoacoustic tomography with ultrasound and x-ray imaging for breast cancer detection

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