Characterization of female breasts in vivo by time-resolved and spectroscopic measurements in the near infrared spectroscopy

Heusmann, Hans; Koelzer, Jochen G.; Mitic, G.

doi:10.1117/12.250669

Cited by 63 publications

(51 citation statements)

References 25 publications

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“…36 Heusmann, Kölzer, and Mitic measured the effects of water in normal breast tissues using incomplete published scattering curves. 37 Quaresima, Matcher, and Ferrari measured the intra-and inter-subject variability of the optical properties of healthy women using second-derivative spectroscopy, again using published scattering data. 12 Cubeddu et al studied physiological changes in breast optical properties during the five phases of the menstrual cycle using a time-resolved, multi-spectral approach.…”

Section: Modern Breast Opticsmentioning

confidence: 99%

Spectroscopy enhances the information content of optical mammography

et al. 2002

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Abstract. Near-infrared (NIR) diffuse optical spectroscopy and imaging may enhance existing technologies for breast cancer screening, diagnosis, and treatment. NIR techniques are based on quantitative measurements of functional contrast between healthy and diseased tissue. In this study we measured the spectral dependence of tissue absorption ( a ) and reduced scattering ( s Ј) in the breasts of 30 healthy women and one woman with a fibroadenoma using a sevenwavelength frequency-domain photon migration probe. Subjects included pre-and postmenopausal women between the ages of 18 and 64. Multi-spectral measurements were used along with a fourcomponent fit to determine the concentrations of de-oxy and oxyhemoglobin, water and lipids in breast. The scattering spectral shape was also quantified. Our measurements demonstrate that the measured concentrations of NIR analytes correlate well with known breast physiology. Although the tissue scattering at a single wavelength was found to have little value as a functional parameter, the dependence of the scattering on wavelength provided key insights into breast composition and physiology. Lipids and scattering spectra in the breast were found to increase and decrease, respectively, with increasing body mass index. Simple calculations are also provided to demonstrate potential penalties from ignoring the contributions of water and lipids in breast measurements. Finally, water is shown to be a possible indicator for detecting a fibroadenoma, whereas the hemoglobin saturation was found to be a poor indicator. Multi-spectral measurements, compared to measurements restricted to one or two wavelengths, provide additional information that may be useful in managing breast disease.

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Section: Modern Breast Opticsmentioning

confidence: 99%

Spectroscopy enhances the information content of optical mammography

et al. 2002

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“…As optical diagnostic methods become more clinically applicable, there is a growing need to identify and quantify sources of endogenous contrast in breast (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). This article presents the results of quantitative NIR spectroscopic studies in 28 subjects ranging in age from 18 to 64 years.…”

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confidence: 99%

Sources of Absorption and Scattering Contrast for Near-Infrared Optical Mammography

et al. 2001

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Rationale and Objectives. Near-infrared (NIR) diffuse optical spectroscopy and imaging may enhance existing technologies for breast cancer screening, diagnosis, and treatment. NIR techniques are based on sensitive, quantitative measurements of functional contrast between healthy and diseased tissue. In this study, the authors quantified the origins of this contrast in healthy breasts. Materials and Methods.A seven-wavelength frequency-domain photon migration probe was used to perform noninvasive NIR measurements in the breasts of 28 healthy women, both pre-and postmenopausal, aged 18 -64 years. A diffusive model of light transport quantified oxygenated and deoxygenated hemoglobin, water, and lipid by their absorption signatures. Changes in the measured light-scattering spectra were quantified by means of a "scatter power" parameter.Results. Substantial quantitative differences were observed in both absorption and scattering spectra of breast as a function of subject age. These physiologic changes were consistent with long-term hormone-dependent transformations that occur in breast. Instrument response was not adversely affected by subject age or menopausal status. Conclusion.These measurements provide new insight into endogenous optical absorption and scattering contrast mechanisms and have important implications for the development of optical mammography. NIR spectroscopy yields quantitative functional information that cannot be obtained with other noninvasive radiologic techniques.

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“…The absorption and diffusion coefficients of the uniform slab are a = 1 / 300 mm −1 and D =1/3 mm, respectively, close to that of human breast tissue. 42 The incident cw beam scans a set of 21ϫ 21 grid points covering an area of 90ϫ 90 mm 2 . The spacing between two consecutive grid points is 4.5 mm.…”

Section: Resultsmentioning

confidence: 99%

Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography

Alfano¹,

Gayen²

2006

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. (From -To) REPORT DATE (DD-MM-YYYY) 01-04-2006 REPORT TYPE Annual DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERResearch Foundation of CUNY New York, New York 10019-2925 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThe research carried out during the current reporting period included: (a) Setting up of the near-infrared optical imaging experimental arrangements, (b) Development of an approach for optical tomographic imaging using independent component analysis (OPTICA), (c) Development of a tomographic image reconstruction approach using the "round-trip matrix approach, and, (d) Target detection and localization using the combined experimental and theoretical approaches. OPTICA is applicable for detection and localization of scattering, absorptive, and fluorescent targets and was demonstrated to provide locations of targets in model media, breast phantoms, and model breasts assembled using ex vivo human breast tissues with millimeter accuracy. The "round-trip matrix" approach could locate 6 targets embedded in a turbid medium that is 50 transport mean free path thick in simulation. These results have potential applications in obtaining accurate location of tumors within breast, as well as, in lumpectomy. SUBJECT TERMS INTRODUCTIONThe goal of the proposed research, "Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography," is to develop a safe and affordable breast cancer detection modality that uses noninvasive near-infrared (NIR) light for imaging and diagnosing tumors in human breast with high resolution and specificity. The project involves developing (a) experimental approach for probing the specimen using NIR light and collecting two-dimensional (2-D) images, and (b) image reconstruction and target localization algorithms that make use of the experimental d...

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Characterization of female breasts in vivo by time-resolved and spectroscopic measurements in the near infrared spectroscopy

Cited by 63 publications

References 25 publications

Spectroscopy enhances the information content of optical mammography

Spectroscopy enhances the information content of optical mammography

Sources of Absorption and Scattering Contrast for Near-Infrared Optical Mammography

Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography

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