&lt;title&gt;Lasers and fiber optics in medicine&lt;/title&gt;

Tuchin, Valery V.

doi:10.1117/12.146456

Cited by 26 publications

(51 citation statements)

References 4 publications

(4 reference statements)

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“…Light is slightly attenuated, mainly in the relatively thin vessel wall, without any influence from other tissues, as it is in other models. The refractive indexes in the typical spectral range of 400-700 nm used for studies are lower for rat mesenteric tissue (n = 1.38) than for rat skin (n = 1.40-1.42) and, especially, for the epidermis (n = 1.55) for humans; thus, it is close to that of water (n = 1.33) [97] . As a result, these optical and geometric features significantly reduce unwanted scattered light, allowing the use of a microscopic objective with a high numerical aperture (up to 1.4) and high magnification (60× -100×).…”

Section: Animal Modelsmentioning

confidence: 97%

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Galanzha¹

2007

WJG

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Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo . Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell's functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo-and radio-sensitivity tests, and drug screening, are also discussed. TOPIC HIGHLIGHT

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Section: Animal Modelsmentioning

confidence: 97%

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Galanzha¹

2007

WJG

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“…This method, which has found wide application in nondestructive testing of materials [9][10][11], is also a promising method of diagnostics in biology and medicine [7,[12][13][14][15]. The method of digital speckle correlation is also suitable for the remote measurement of microdisplacements and speed of various processes [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…One of the most promising technics for the measurement of microdisplacements and deformations is a method of digital speckle correlation [6][7][8]. This method, which has found wide application in nondestructive testing of materials [9][10][11], is also a promising method of diagnostics in biology and medicine [7,[12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Speckle pattern processing by digital image correlation

Gubarev

Klenovskii

et al. 2016

MATEC Web of Conferences

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Abstract. Testing the method of speckle pattern processing based on the digital image correlation is carried out in the current work. Three the most widely used formulas of the correlation coefficient are tested. To determine the accuracy of the speckle pattern processing, test speckle patterns with known displacement are used. The optimal size of a speckle pattern template used for determination of correlation and corresponding the speckle pattern displacement is also considered in the work.

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“…The safety of these methods and the possibility to get information in real time explain their wide usage and permanent expansion of the application field in medicine [20, 38, 48, [146][147][148][149]. Using optical radiation one can also extract information on the structure, composition, and properties of biological tissues, investigate metabolic processes avoiding negative effect on them [144]. An essential advantage of visible and near-infrared optical radiation is its capability of sufficiently deep penetration into biological tissues.…”

Section: Blood and Cardiovascular Systemmentioning

confidence: 99%

“…Optical methods of diagnosing the condition of biological tissues are widely used in biology and medicine, e.g., for determination of oxygenation degree and blood perfusion [144,145]. The safety of these methods and the possibility to get information in real time explain their wide usage and permanent expansion of the application field in medicine [20, 38, 48, [146][147][148][149].…”

Section: Blood and Cardiovascular Systemmentioning

confidence: 99%

Optical and structural properties of biological tissues under diabetes mellitus

Tuchina

Tuchin

2018

J-BPE

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Abstract. Diabetes mellitus is a serious social and economic problem of modern society because it is widespread and fraught with numerous complications. Therefore, it is necessary to search for new methods of diabetes mellitus diagnostics and treatment and to improve the existing ones, which, in turn, requires thorough investigation of the disease development mechanisms, as well as elaboration of simple and reliable methods and criteria for detecting the complication precursors. In connection with the solution of these problems, in the paper we present an analytical review of recent publications devoted to the study of the changes of structural and optical properties of biological tissues under the conditions of diabetes mellitus development using in vitro models of glycated tissues, in vivo experimental models of diabetes in laboratory animals, and clinical studies.

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<title>Lasers and fiber optics in medicine</title>

Cited by 26 publications

References 4 publications

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Speckle pattern processing by digital image correlation

Optical and structural properties of biological tissues under diabetes mellitus

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