&lt;title&gt;Investigation of glucose-hemoglobin interaction by optical coherence tomography&lt;/title&gt;

Zhernovaya, Olga S.; Bashkatov, Alexey N.; Genina, Elina A.; Tuchin, Valery V.; Meglinski, Igor; Churmakov, Dmitry Y.; Ritchie, Laurie

doi:10.1117/12.740985

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…the tissues) [32]. The calculation of the percentage of blood's glycated hemoglobin is very important for diabetic patients [33]. Increasing of glycated hemoglobin concentration refers to that the levels of the glucose of blood are not naturally controlled with proper body response [34].…”

Section: Introductionmentioning

confidence: 99%

Ultra-sensitive acoustic biosensor based on a 1D phononic crystal

et al. 2020

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In this work, we introduce an ultra-sensitive acoustic biosensor based on a 1D phononic crystal (1D-PnC) to measure separately albumin, hemoglobin and hemocyanin concentrations. This study represents a new type of acoustic biosensors with very high sensitivity in a very broad molar ratio range. Lead-epoxy 1D-PnC multilayer stack confining a defect layer from the biomaterials to generate strong and well-separated resonance modes within the phononic band gap is proposed. For albumin, we calculated a sensitivity value of about 3.5 MHz over a concentration range between 0%–36%. For hemoglobin, the sensitivity was about 3.314 MHz over a concentration range between 0%–14%. For hemocyanin, the sensitivity was about 3.41 MHz over a concentration range between 0%–15.5%. Besides the sensitivity, the 1D-PnC showed high performance represented by high Q-factor and figure of merit values. The transfer matrix method is adopted for calculating the transmission coefficient of the incident acoustic wave. We believe these results could be useful in the design of an effective biosensor especially it has many merits such as low cost, ease of fabrication, high sensitivity, and absence of any electronic component.

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Section: Introductionmentioning

confidence: 99%

Ultra-sensitive acoustic biosensor based on a 1D phononic crystal

et al. 2020

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“…Since the high level of blood glucose leads to the growth of its content in the interstitial fluid, the glycation affects not only the blood proteins, such as albumin and hemoglobin [70,129,135,138,155], but also other proteins of the organism tissues. For example, in Refs.…”

Section: Different Tissuesmentioning

confidence: 99%

“…The hyperglycemia accelerates the atherosclerotic processes [13, 61,63], the atherosclerosis and the corresponding loss of elasticity of coronary artery walls cause stenosis and, therefore, reduce the blood supply to the cardiac muscle, which finally leads to angina pectoris, cardiomyopathy, and increased risk of myocardial infarction [12,13,63,64]. These serious complications are due to the glycation of proteins in vascular walls permanently washed by blood in the presence of increased free glucose content in blood [41,129,135,138]. Different methods are used to determine glycated hemoglobin or albumin, such as ion exchange, affine, or liquid chromatography, electrophoresis, colorimetric and immunochemical methods [70,143].…”

Section: Blood and Cardiovascular Systemmentioning

confidence: 99%

“…The glycation is a result of the interaction between the glucose molecules and the proteins, which leads to the change of protein structure and to the restriction of To study the glycation of proteins, both the samples of tissues and cells from the objects with natural or artificially induced diabetes mellitus (in vivo glycation), as well as the samples that has been glycated under in vitro conditions are used. Studies of in vitro glycation refer, for example, to human placental type IV collagen, performed by fluorescence analysis, as well as by electrophoresis and densitometry [134]; collagen of bovine skin -using multiphoton microscopy [34]; hemoglobin -by optical coherent tomography [135][136][137], refractometry and IR spectroscopy [122], as well as biochemical analysis [138]; albumin -using fluorescence spectroscopy [70], refractometry [122], and terahertz spectroscopy [138]; collagen of the tendon -through biochemical and biomechanical analyzes [139], as well as to collagen hydrogels -using multispectral fluorescence life time imaging (FLIM) [140]; by incubation in ribose [37,134,139,140], glucose [70,122,135,138,141] or fructose [70,141] solutions. All of them show a sufficiently effective glycation of proteins during 10-11 days of incubation, a change in the mechanical properties of tissues due to the formation of collagen cross-links.…”

Section: Glycation and Non-enzymatic Glycation Of Proteinsmentioning

confidence: 99%

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Optical and structural properties of biological tissues under diabetes mellitus

Tuchina

Tuchin

2018

J-BPE

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Abstract. Diabetes mellitus is a serious social and economic problem of modern society because it is widespread and fraught with numerous complications. Therefore, it is necessary to search for new methods of diabetes mellitus diagnostics and treatment and to improve the existing ones, which, in turn, requires thorough investigation of the disease development mechanisms, as well as elaboration of simple and reliable methods and criteria for detecting the complication precursors. In connection with the solution of these problems, in the paper we present an analytical review of recent publications devoted to the study of the changes of structural and optical properties of biological tissues under the conditions of diabetes mellitus development using in vitro models of glycated tissues, in vivo experimental models of diabetes in laboratory animals, and clinical studies.

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Ex vivo optical measurements of glucose diffusion kinetics in native and diabetic mouse skin

Tuchina

Shi

Bashkatov

et al. 2015

Journal of Biophotonics

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The aim of this study was to estimate the glucose diffusion coefficients ex vivo in skin of mice with diabetes induced in vivo by alloxan in comparison to non‐diabetic mice. The temporal dependences of collimated transmittance of tissue samples immersed in glucose solutions were measured in the VIS‐NIR spectral range to quantify the glucose diffusion/permeability coefficients and optical clearing efficiency of mouse skin. The average thickness of intact healthy and diabetic skin was 0.023 ± 0.006 cm and 0.019 ± 0.005 cm, respectively. Considerable differences in optical and kinetic properties of diabetic and non‐diabetic skin were found: clearing efficiency was 1.5‐fold better and glucose diffusivity was 2‐fold slower for diabetic skin. Experimental Setup for measuring collimated transmittance spectra of mouse skin samples.magnified imageExperimental Setup for measuring collimated transmittance spectra of mouse skin samples.

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<title>Investigation of glucose-hemoglobin interaction by optical coherence tomography</title>

Cited by 4 publications

References 12 publications

Ultra-sensitive acoustic biosensor based on a 1D phononic crystal

Ultra-sensitive acoustic biosensor based on a 1D phononic crystal

Optical and structural properties of biological tissues under diabetes mellitus

Ex vivo optical measurements of glucose diffusion kinetics in native and diabetic mouse skin

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