<p>Wheat seeds can delay orthodontic tooth movement by blocking osteoclastogenesis in rats</p>

Abstract

Background The hormone estrogen can prevent osteoclast differentiation and suppress osteoclastic activity, which can prevent tooth relapse movement. Wheat seeds are a natural material containing phytoestrogens with similar characteristics to estrogen. Objective This study intends to determine the influence of wheat seeds in reducing osteoclastogenesis following orthodontic tooth movement (OTM). Materials and methods Forty male Sprague Dawley rats were used in this experimental study. The rats were divided into control and treatment groups (n=20). In both groups, the rat maxillary incisors were moved distally using a 0.012 U stainless steel orthodontic appliance with a 2 mm diameter coil and 5 mm wire length. The treatment group received wheat seeds at a dose of 0.6 gram/day. The animals were sacrificed at days 0, 1, 7, and 14 after using the orthodontic appliance (4 subgroups according to observations of days; n=5). RANKL and OPG expressions were determined from the gingival crevicular fluid (GCF) samples using ELISA analysis. Statistical analysis of the data collected was calculated with the independent sample t -test ( P <0.05). Results All the experimental procedures were well-tolerated and did not change the animals’ weight. On days 7 and 14, the OTM rate of the treatment group was significantly lower than the control group ( P <0.05). ELISA test results showed that the OPG level was significantly higher on days 1, 7, and 14, while the RANKL level was considerably lower on day 14 in the wheat seeds group compared with the control group ( P <0.05). Conclusion Wheat seeds can promote osteoclastogenesis inhibition and delay OTM.

Different effects of soybean isoflavone genistein on transforming growth factor levels during orthodontic tooth movement among young and old rabbits

“…The success of orthodontic treatment depends on the process of alveolar bone tissue remodeling during the treatment which involves bone apposition and resorption by osteoblasts and osteoclasts 6 . For children and juveniles who are in an early stage of growth and development, bone apposition and resorption are balanced.…”

Postorthodontic Relapse Prevention by Administration of Grape Seed (Vitis vinifera) Extract Containing Cyanidine in Rats

“…6,7 Therefore, natural remedies might be an alternative to reduce those effects. 8 Grape seeds are a natural source of proanthocyanidins, one of the phenolic compounds. Furthermore, one of the proanthocyanidin members, procyanidin, forms a complex known as cyanidin.…”

Effect of cocoa administration during orthodontic tooth movement on RUNX2, calcium levels, and osteoclast bone-resorbing activity in rats

“…In early studies, RUNX2 induction lowered the expression of OPG (Baniwal et al, 2012). As OPG functions as a decoy receptor for RANKL, a key activator of osteoclastogenesis, it is anticipated that a decrease in OPG level will allow RANKL activity and hence enhance osteoclastogenesis (Suparwitri et al, 2019). Enhancing osteoclastogenesis during orthodontic tooth movement facilitates rapid orthodontic tooth movement (Alhasyimi and Rosyida, 2019).…”