<p>The Research Progress on the Prognostic Value of the Common Hematological Parameters in Peripheral Venous Blood in Breast Cancer</p>

Abstract

Breast carcinoma is one of the most malignant tumors, severely influencing the physical and mental health of people. The latest epidemiological and clinical studies have found that breast tumor and inflammation are determinate relationships with each other. Inflammation is an essential component of the tumor microenvironment, and the change of inflammatory cells might influence tumor progression, such as neoplastic cell proliferation, migration, invasion, the collapse of antitumor immunity, metastasis and so forth. Peripheral blood tests at the time of diagnosis and treatment can reflect inflammatory conditions within the neoplasm. Evaluation of peripheral blood parameters including white blood cell, neutrophil, lymphocyte, monocyte, platelet counts, as well as neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (d-NLR) (neutrophil count divided by the result of white blood cell count minus neutrophil count), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), which are indicators of systematic inflammatory response, have been widely proposed as prognostic factors for many malignancies. To intensively study the relationship between the common markers in peripheral blood and the treatment or prognosis of breast cancer will have critical clinical significance and application prospect, and can provide useful information for the clinicians. Herein, we review the research progress in the prognostic role of the peripheral blood in breast cancer to provide a new method for the treatment and prognosis of breast cancer.

Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious?

“…The mean total leukocyte count did not show any significant correlation with the control group but as the disease progressed from stage 1 to stage 4, the count decreased. The total leukocyte count is greatly affected by increase or decrease of neutrophils, eosinophils, lymphocytes, monocytes and basophils 11 . In the present study, the absolute neutrophil count did not show any significant correlation with the control group nor also with staging.…”

“…The NLR ratio was found to be higher in patients with axillary lymph node metastasis. Many studies have shown that a pre-operative increase in the NLR ratio suggests poor prognosis of the breast cancer patients; it can be used as an independent prognostic factor in breast carcinoma 11,16 . The process for elevated NLR is explained by relative increase in the neutrophil count and relative decrease in the lymphocyte count, causing the breakdown of balance in the tumour microenvironment.…”

“…Cellular immune responses decrease as a consequence to lymphocytopenia and there is an increase in the inflammatory response. This increase in inflammation causes an increase in tumor growth, invasion and metastasis 11,15,16 . The usefulness of the NLR in predicting short-and long-term mortality in breast cancer patients was first evaluated by Azab et al 17 .…”

<p>The Prognostic Value of Inflammation Factors in Hepatocellular Carcinoma Patients with Hepatic Artery Interventional Treatments: A Retrospective Study</p>

“…59 As indicators of systematic inflammation status, neutrophil and monocyte were reported to have participated in tumor cell proliferation and migration, tumor progression and metastasis. 60 However, lymphocyte plays a key role in anti-tumor reaction, and lymphocyte cell counts reflect immune response status. Therefore, the levels of NLR, PLR and MLR could indicate the severity of aggressive Notes: Confidential Interval.…”

Sociodemographic and Hematologic Profile of Breast Cancer Patients Attending a Tertiary Care Teaching Hospital in Ethiopia: Case Control Study

“…They are cost effective and can be easily examined in less complex laboratories that do not have access to sophisticated technology for demonstration of more reliable cancer markers (14). Studies indicate hematological parameters as important investigations that are useful prognostic factors for evaluating the accuracy of risk strati cation in breast cancer patients (15,16). For example, a study done in south western Nigeria showed that HB, PCV, RBC and WBC were signi cantly lower in patients compared to controls (16).…”