Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious?

Shilpa, M; Raju, Kalyani; Sreeramulu, P N

doi:10.15419/bmrat.v7i8.621

Cited by 6 publications

(11 citation statements)

References 13 publications

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“…This finding is similar to the study conducted in Ethiopia, which showed that the prevalence of thrombocytopenia was 23.5% [21]. In contrast to this study, a study conducted in Switzerland revealed that thrombocytosis was increased throughout the treatment [11]. This variation could be due to the sample size, clinical characteristics, and socio-demographic differences between the study groups.…”

Section: Plos Onesupporting

confidence: 83%

“…Pretreatment hematological abnormalities are mostly due to suppression of hematopoiesis via bone marrow infiltration [8,9]. Several studies confirm that pretreatment anemia, neutropenia, and thrombocytopenia were found to be common in breast cancer patients [10,11]. The post-treatment hematological abnormalities are associated not only with the malignant cell effect, but also with the chemotherapy and radiotherapy medications administered to the patients [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Hematological abnormalities before and after initiation of cancer treatment among breast cancer patients attending at the University of Gondar comprehensive specialized hospital cancer treatment center

et al. 2022

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Background Breast cancer is the most frequent and fatal cancer type globally. The fatality rate of breast cancer is mostly due to disease complications like hematological alterations. Therefore, this study aimed to assess the hematological abnormalities before, during, and after the initiation of cancer treatment in breast cancer patients at the University of Gondar comprehensive specialized hospital. Methodology Hematological profiles were collected from 267 breast cancer patients who attended the cancer treatment center from September 2017 to August 2021. A data extraction sheet was used to extract data from the patient’s medical chart, including sociodemography, clinical, and hematological profiles. EPI info version 3.5.1 and SPSS Version 25 softwares were used for data entrance and analysis, respectively. Descriptive statistics were summarized using frequency and percentage. The Friedman test followed by a Wilcoxon signed rank test was used to compare the mean difference between the hematological profiles at zero and after the 4th and 8th cycles of treatment. Result Of the total participants, 91% were females, and the median age of the study participants was 45 (IQR = 36, 55) years. Red blood cell, white blood cell, and lymphocyte counts, as well as hematocrit and hemoglobin values, were significantly reduced after the initiation of cancer treatment, while the platelet count and red cell distribution width were significantly increased. The prevalence of anemia was 21.7% (95% CI: 16.6, 26.8), 22.7% (95% CI: 17.6, 27.8), and 26.4% (95% CI: 21.3, 31.5) before, during, and after the initiation of cancer treatment, respectively. The prevalence of leukopenia before, during, and after treatment was 9.7%, 18.8%, and 15.1%, respectively. Finally the prevalence of thrombocytopenia was 6.3%, 3.4%, and 8% at before, during, and after treatment, respectively. Conclusion This study concluded that many hematological parameters were significantly affected by the breast cancer treatment. Therefore, proper patient follow-up and provide appropriate interventions related to their hematological abnormalities is crucial. It is also important to conduct further prospective studies to confirm the findings of this study.

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Section: Plos Onesupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Hematological abnormalities before and after initiation of cancer treatment among breast cancer patients attending at the University of Gondar comprehensive specialized hospital cancer treatment center

et al. 2022

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“…Our finding is in agreement with studies reported from India; they concluded that the levels of Hgb, WCC, RCC and PLT counts significantly altered in the HIV-infected patients when compared with the HCs 22 23. Changes in the haematological indices might be due to the effects of the infections on the blood cells 24 25. Comparable findings were reported in Turkey26 27 and Egypt 28.…”

Section: Discussionsupporting

confidence: 92%

Diagnostic utility of haematological parameters in predicting the severity of HIV infection in southwestern Ethiopia: a comparative cross-sectional study

Haile,

Timerga,

Alemayehu

et al. 2023

BMJ Open

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ObjectivesThis study aimed to evaluate the diagnostic utility of haematological parameters as a predictive marker of the severity of HIV infection in southwestern Ethiopia.DesignComparative cross-sectional study.SettingThis study was conducted in southwestern Ethiopia.ParticipantsVenous blood samples were collected from 344 participants (172 HIV, 172 healthy controls (HC)) and haematological parameters were determined using the automated haematology analyser. The diagnostic utility of haematological parameters was determined by a receiver operating curve analysis. Data were analysed using SPSS V.21 and the p value was set at less than 0.05 for the statistical significance.ResultsIn this study, red cell count (RCC) distinguishes HIV-infected patients from HC at a threshold value of 4.05×109/L with sensitivity, specificity and an area under the curves (AUC) of 73.8%, 78.5% and 0.87, respectively. At a cut-off value of 4.25×109/L, RCC significantly distinguishes non-severe HIV-infected patients from HC with a sensitivity of 72.7%, specificity of 81.7% and an AUC of 0.86. Haemoglobin (Hgb) significantly differentiates severe HIV-infected patients from HC with sensitivity, specificity and an AUC of 95.9%, 86.7% and 0.96, respectively. Platelet count (PLT) significantly discriminates HC from non-severe and severe HIV-infected patients with an AUC of 0.74 and 0.963, respectively.ConclusionRCC, PLT and Hgb demonstrated better diagnostic performance in predicting the severity of HIV infection and have been identified as the best haematological markers in predicting the presence and severity of HIV infection. Thus, the haematological profiles (RCC, PLT and Hgb) should be used as an alternative marker to predict the severity of HIV infection and may provide supportive information for evidence-based interventions and early diagnosis of infections.

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“…( 25 ) also revealed that eosinophils are involved in the immune response to breast tumors. Various studies also reported that platelets release chemokines in response to drug toxicity and increase eosinophil counts through chemicals (eosinophils activating factor, Platelet P-selectin) released from platelets ( 34 , 35 ). These chemicals inhibit Eosinophils apoptosis and prolong survival ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Adriamycin-Cytoxan chemotherapy on hematological and electrolyte parameters among breast cancer patients

Tadesse

Leminie

2023

Front. Oncol.

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BackgroundAdriamycin-Cytoxan (AC) is a common chemotherapy treatment for breast cancer (BC) patients. Its electrolyte and hematological adverse effects have not been addressed adequately.ObjectiveThis study aimed to assess the effect of AC on hematological and electrolyte parameters among BC patients.MethodsA hospital-based comparative cross-sectional study design was conducted from March to November 2022. Randomly selected AC-treated (n=100) and untreated (n=100) patients were included. Structured questionnaire and medical records were used to collect sociodemographic data. Anthropometric parameters, hematological indices, and serum electrolytes were measured. Cobas Integra 400+and SYSMEX-XT-4000i were used to analyze serum electrolytes and hematological indices respectively. The data were analyzed using SPSS version 25. Independent t-test and chi-square test were used. p-value <0.05 was considered statistically significant.ResultsAC-treated patients’ mean total white blood cell (TWBC), neutrophil (NE), lymphocyte (LY), red blood cell (RBC), hemoglobin (Hgb), hematocrit (HCT), and sodium(Na+) values were significantly reduced (p<0.05) than patients with no treatment. However, mean eosinophils (EO), platelet (PLT) counts, red cell distribution-width (RDW), potassium (K+), and plateletcrit (PCT values were significantly increased (p<0.05).ConclusionThe majority of blood cells and serum sodium were affected by AC treatment. Incorporating these parameters in the routine analysis and further studies on the detailed mechanism of action of this drug is required.

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Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious?

Cited by 6 publications

References 13 publications

Hematological abnormalities before and after initiation of cancer treatment among breast cancer patients attending at the University of Gondar comprehensive specialized hospital cancer treatment center

Hematological abnormalities before and after initiation of cancer treatment among breast cancer patients attending at the University of Gondar comprehensive specialized hospital cancer treatment center

Diagnostic utility of haematological parameters in predicting the severity of HIV infection in southwestern Ethiopia: a comparative cross-sectional study

Effects of Adriamycin-Cytoxan chemotherapy on hematological and electrolyte parameters among breast cancer patients

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