&lt;p&gt;The LINC00365/SCGB2A1 (Mammaglobin B) Axis Down-Regulates NF-κB Signaling and Is Associated with the Progression of Gastric Cancer&lt;/p&gt;

Yan, Xiaoyu; Zhang, Juanjuan; Zhong, Xinru; Yu, Shuyou; Xu, Long; Tian, Rui; Sun, Liankun; Su, Jing

doi:10.2147/cmar.s223699

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…LINC00365 influences the Wnt/β-catenin signaling pathway, which modulates colorectal cancer (CRC) progression ( 53 ), and breast cancer cell viability may be regulated by the LINC00365-secretoglobin family 2A member 1 (SCGB2A1) axis, which targets NF-κB signaling ( 54 ). In GC, the expression levels of LINC00365 and SCGB2A1 are downregulated in tumor tissues, which is associated with a shorter survival time ( 55 ). Notably, this LINC00365/SCGB2A1 axis and associated NF-κB suppression are associated with GC progression ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

“…In GC, the expression levels of LINC00365 and SCGB2A1 are downregulated in tumor tissues, which is associated with a shorter survival time ( 55 ). Notably, this LINC00365/SCGB2A1 axis and associated NF-κB suppression are associated with GC progression ( 55 ). In the present study, SOX21-AS1 was demonstrated to be associated with GC in the ceRNA network.…”

Section: Discussionmentioning

confidence: 99%

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Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

Jiang

Zhang

et al. 2021

Oncol Lett

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Gastric cancer (GC) is a common type of cancer, and identification of novel diagnostic biomarkers associated with this disease is important. The present study aimed to identify novel diagnostic biomarkers associated with the prognosis of GC, using an integrated bioinformatics approach. Differentially expressed long non-coding RNAs (lncRNAs) associated with GC were identified using Gene Expression Omnibus datasets (GSE58828, GSE72305 and GSE99416) and The Cancer Genome Atlas database. A competing endogenous RNA network that incorporated five lncRNAs [long intergenic non-protein coding RNA 501 (LINC00501), LINC00365, SOX21 antisense divergent transcript 1 (SOX21-AS1), GK intronic transcript 1 (GK-IT1) and DLEU7 antisense RNA 1 (DLEU7-AS1)], 29 microRNAs and 114 mRNAs was constructed. Gene Ontology and protein-protein interaction network analyses revealed that these lncRNAs may be involved in ‘biological regulation’, ‘metabolic process’, ‘cell communication’, ‘developmental process’, ‘cell proliferation’, ‘reproduction’ and the ‘cell cycle’. The results of receiver operating characteristic curve analysis demonstrated that LINC00501 (AUC=0.819), LINC00365 (AUC=0.580), SOX21-AS1 (AUC=0.736), GK-IT1 (AUC=0.823) and DLEU7-AS1 (AUC=0.932) had the potential to become valuable diagnostic biomarkers for GC. Associations with clinicopathological characteristics demonstrated that LINC00501 expression was significantly associated with sex (P=0.015) and tumor grade (P=0.022). Furthermore, LINC00365 expression was significantly associated with lymph node metastasis (P=0.025). Gene set enrichment analysis revealed that LINC00501, LINC00365 and SOX21-AS1 were enriched in signaling pathways associated with GC. Reverse transcription-quantitative PCR analysis demonstrated that LINC00501 expression (P=0.043) was significantly upregulated in GC tissues, whereas the expression levels of LINC00365 (P=0.033) and SOX21-AS1 (P=0.037) were significantly downregulated in GC tissues. Taken together, the results of the present study suggest that LINC00501, LINC00365, SOX21-AS1, GK-IT1 and DLEU7-AS1 may be used as novel diagnostic biomarkers for GC, and may be functionally associated with GC development and progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

Jiang

Zhang

et al. 2021

Oncol Lett

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“…Low LINC00365 expression was closely related to short survival time. In vitro data indicated that LINC00365 up‐regulation suppressed the proliferation ability of gastric cancer cells 15 . By contrast, LINC00365 was up‐regulated in the colorectal cancer, associating with worse outcome of patients.…”

Section: Introductionmentioning

confidence: 96%

“…In vitro data indicated that LINC00365 up-regulation suppressed the proliferation ability of gastric cancer cells. 15 By contrast, LINC00365 was up-regulated in the colorectal cancer, associating with worse outcome of patients. LINC00365 overexpression promoted colorectal cancer cells proliferation, migration, and invasion.…”

Section: Introductionmentioning

confidence: 97%

LINC00365 inhibited lung adenocarcinoma progression and glycolysis via sponging miR‐429/KCTD12 axis

Zhang

Zhou

Liu

et al. 2022

Environmental Toxicology

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This study researched the function of long non-coding RNA LINC00365 in lung adenocarcinoma (LAD) progression. LINC00365, miR-429, and KCTD12 expression in the LAD clinical tissues and cells were detcetd by qRT-PCR and Western blot. LINC00365, miR-429, and KCTD12 effects on H1975 cells malignant phenotype were detected by cell counting kit-8 assay, clone formation experiment, Transwell experiment, and glycolysis. Dual luciferase reporter gene assay and RNA pull-down assay were implemented. LINC00365 effect on H1975 cells in vivo growth was detected. LINC00365 was low expressed in the LAD patients and cells, associating with poor outcome. LINC00365 up-regulation attenuated H1975 cells proliferation, migration, invasion, glycolysis and in vivo growth. LINC00365 inhibited KCTD12 expression by sponging miR-429. miR-429 up-regulation and KCTD12 downregulation partial reversed LINC00365 inhibition on H1975 cells malignant phenotype. Thus, LINC00365 inhibited LAD progression and glycolysis via targeting miR-429/KCTD12 axis. LINC00365 might be a potential candidate for LAD target treatment clinically.

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“…The upregulation of LINC00365, acting as a tumor suppressor, has the potential to serve as a prognostic marker in GC. It suppresses GC cell viability by inhibiting expansion rather than stimulating apoptosis [ 143 ]. Additionally, LINC01235 functions as a prognostic biomarker and facilitates the metastasis of GC cells by inducing EMT [ 144 ].…”

Section: Introductionmentioning

confidence: 99%

Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers

Zabeti Touchaei,

Vahidi,

Samadani

2024

Clin Exp Med

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Colorectal cancer (CRC) and gastric cancer (GC) are major contributors to cancer-related mortality worldwide. Despite advancements in understanding molecular mechanisms and improved drug treatments, the overall survival rate for patients remains unsatisfactory. Metastasis and drug resistance are major challenges contributing to the high mortality rate in both CRC and GC. Recent research has shed light on the role of long noncoding RNAs (lncRNAs) in the development and progression of these cancers. LncRNAs regulate gene expression through various mechanisms, including epigenetic modifications and interactions with microRNAs (miRNAs) and proteins. They can serve as miRNA precursors or pseudogenes, modulating gene expression at transcriptional and post-transcriptional levels. Additionally, circulating lncRNAs have emerged as non-invasive biomarkers for the diagnosis, prognosis, and prediction of drug therapy response in CRC and GC. This review explores the intricate relationship between lncRNAs and CRC/GC, encompassing their roles in cancer development, progression, and chemoresistance. Furthermore, it discusses the potential of lncRNAs as therapeutic targets in these malignancies. The interplay between lncRNAs, miRNAs, and tumor microenvironment is also highlighted, emphasizing their impact on the complexity of cancer biology. Understanding the regulatory landscape and molecular mechanisms governed by lncRNAs in CRC and GC is crucial for the development of effective diagnostic and prognostic biomarkers, as well as novel therapeutic strategies. This review provides a comprehensive overview of the current knowledge and paves the way for further exploration of lncRNAs as key players in the management of CRC and GC. Graphical Abstract

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<p>The LINC00365/SCGB2A1 (Mammaglobin B) Axis Down-Regulates NF-κB Signaling and Is Associated with the Progression of Gastric Cancer</p>

Cited by 9 publications

References 33 publications

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

LINC00365 inhibited lung adenocarcinoma progression and glycolysis via sponging miR‐429/KCTD12 axis

Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers

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