<scp>LINC00365</scp> inhibited lung adenocarcinoma progression and glycolysis via sponging <scp>miR</scp>‐429/<scp>KCTD12</scp> axis

Zhang, Cheng-Wei; Zhou, Bin; Liu, Yanchao; Su, Liya; Meng, Jian; Li, Shaolei; Wang, Xue-Long

doi:10.1002/tox.23532

Cited by 5 publications

(2 citation statements)

References 52 publications

(95 reference statements)

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“…LINC00365 could be a potential candidate for targeted therapy of lung adenocarcinoma clinically. [ 24 ] The role of LINC00365 in inhibiting or promoting EC has not been studied, but our result showed it was significantly lower expressed in EC patients. The expression of TMEM75 was upregulated in colorectal cancer tissues compared with nontumor tissues and positively correlated with the advanced clinical stage.…”

Section: Discussionmentioning

confidence: 82%

A novel prognosis prediction of esophageal cancer based on chromatin regulator-related lncRNA

et al. 2023

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It has been reported that chromatin regulators (CRs), as one of the essential upstream regulators of tumor development, were screened to construct a prognostic model for predicting the outcome of tumor patients. However, the prognostic model based on CRs-related long noncoding RNAs (lncRNAs) in esophageal cancer (EC) has never been researched. This study aims to construct a novel CRs-related lncRNA signature to evaluate the prognostic ability of EC patients. We obtained the transcriptome data and clinical information of patients with EC from the Cancer Genome Atlas database, 870 CRs-related genes from previous topic research. Univariate, multivariate Cox, the least absolute shrinkage and selection operator regression analyses were used to establish the risk model. The receiver operating characteristic curve, principal component analysis, nomogram, quantitative real-time PCR were performed to evaluate the independence and accuracy of the model. The biological functions and immune microenvironment of the risk model were analyzed by gene set enrichment analyses and R softwares. A novel 3 CRs-related lncRNAs risk model composed of AC079684.1, TMEM75, LINC00365, as an independent and superior factor, was established for prognosis prediction of EC patients. Quantitative real-time PCR analysis verified upregulated AC079684.1 and TMEM75 mRNA levels and downregulated LINC00365 mRNA level in EC tissues compared with normal tissues. Gene set enrichment analysis analysis displayed Kyoto encyclopedia of genes and genomes and gene ontology pathways enriched in risk groups, such as focal adhesion, pathways in cancer, epidermal cell differentiation. Immune cells and immune checkpoints were more likely to be activated in the high-risk group. Finally, we found most of the compounds in the high-risk group exhibited higher sensitivity through therapeutic drug screening. The 3 CRs-related lncRNAs risk model could independently predict the prognosis of EC and provide immunotherapy guidance for patients with EC.

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Section: Discussionmentioning

confidence: 82%

A novel prognosis prediction of esophageal cancer based on chromatin regulator-related lncRNA

et al. 2023

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“…KCTD12 is an emerging biomarker for sarcoma that has been demonstrated by immunohistochemistry in multi-center studies on patients with clinical sarcoma 19 . KCTD12 can combine with miRNAs as the information transmission axis component of LINC00365 to regulate glycolysis in LUAD cells, thereby affecting the progression of LUAD 20 . KCTD12 inhibits the proliferation and invasion of UVM and ESCA as well as the growth of xenograft tumors.…”

Section: Discussionmentioning

confidence: 99%

A pan-cancer analysis of potassium channel tetramerization domain containing 12 in human cancer

Liu,

Luo

et al. 2023

Sci Rep

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Abnormal expression of the potassium channel tetramerization domain containing 12 (KCTD12) is closely related to the occurrence and development of various tumors, but a pan-cancer analysis of KCTD12 has not yet been conducted. We explored the association between KCTD12 and more than 30 human malignancies using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. First, the mRNA and protein levels of KCTD12 were examined and their correlations with tumor stage and survival were explored. Second, we analyzed the infiltration of CD8+ and CD4+ T cells and cancer-associated fibroblasts in tumors and explored the correlation between KCTD12 expression and tumor cell stemness, genomic heterogeneity, and diagnostic specificity. Finally, we explored the molecular mechanisms associated with KCTD12 using KEGG/GO analysis. The results showed that KCTD12 mRNA and protein expression levels decreased in most tumors was significantly associated with the prognosis of tumor patients, and the phosphorylation level of KCTD12 decreased in several tumors, such as S200 and T196, pancreatic adenocarcinoma (PAAD), lung adenocarcinoma (LUAD), and breast invasive cancer (BRCA). The expression of KCTD12 was positively correlated with the degree of cancer-associated fibroblasts infiltration in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), head and neck squamous cell carcinoma (HNSC), PAAD, and stomach adenocarcinoma (STAD). The relationship between KCTD12 expression and CD8+ and CD4+ T cell infiltration was also clarified. KCTD12 showed high diagnostic sensitivity for various types of tumors and may be involved in tumor cell biology by affecting tumor cell stemness, tumor burden, and other characteristics. Finally, we analyzed the molecular functions of KCTD12 and possible KEGG/GO signaling pathways. In this study, we developed a biological marker for diagnosis, prognosis, and immune infiltration of the pan-cancers.

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DLGAP5 knockdown inactivates the Wnt/β‐catenin signal to repress endometrial cancer cell malignant activities

Chen

Liu

et al. 2022

Environmental Toxicology

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Human discs large‐associated protein 5 (DLGAP5), a microtubule‐associated protein, has been reported to be upregulated in several tumors. However, the role of DLGAP5 in endometrial cancer (EC) progression and the related underlying mechanism were still unknown. A bioinformatics analysis was performed to analyze the expression and prognostic significance of DLGAP5 in EC tissues using TCGA, CPTAC, Human Protein Atlas, and GSE63678 databases, UALCAN web tool, and the Kaplan–Meier plotter. Effects of DLGAP on EC cell malignant properties were evaluated by CCK‐8, flow cytometry analysis, TUNEL assay, caspase‐3 activity assay, and Transwell invasion assay. The expression of DLGAP5, Wnt3, c‐Myc, Ki67, and cleaved caspase‐3 was detected by western blot analysis. DLGAP5 was highly expressed and correlated with poor prognosis in EC patients. DLGAP5 knockdown inhibited proliferation and invasion, triggered apoptosis, and increased caspase‐3 activity in EC cells. Additionally, DLGAP5 knockdown inactivated the Wnt/β‐catenin signaling pathway in EC cells. Moreover, β‐catenin overexpression abolished the effects of DLGAP5 knockdown on the malignant phenotypes of EC cells. DLGAP5 silencing suppressed the malignant properties in EC cells by inactivating the Wnt/β‐catenin pathway.

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LINC00365 inhibited lung adenocarcinoma progression and glycolysis via sponging miR‐429/KCTD12 axis

Cited by 5 publications

References 52 publications

A novel prognosis prediction of esophageal cancer based on chromatin regulator-related lncRNA

A novel prognosis prediction of esophageal cancer based on chromatin regulator-related lncRNA

A pan-cancer analysis of potassium channel tetramerization domain containing 12 in human cancer

DLGAP5 knockdown inactivates the Wnt/β‐catenin signal to repress endometrial cancer cell malignant activities

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