&lt;p&gt;The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant&lt;/p&gt;

Wang, Haiyan; Xu, Qiuping; Hu, Hui; Shi, Chunling; Lin, Ziyan; Jiang, Huixi; Dong, Huaipu; Guo, Jing

doi:10.2147/ijn.s268657

Cited by 23 publications

(24 citation statements)

References 61 publications

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“…The observed phenomenon may be attributed to the nano-needle-like structure possessing high surface roughness, whereas the Ta nano-coating enabled the surface to become smooth ( Noumbissi et al, 2019 ). The result corresponds with a previous study which showed that a strontium nanolayer slightly decreased the surface roughness of hot-alkaline treated titanium surfaces ( Wang et al, 2020 ).…”

Section: Resultssupporting

confidence: 92%

“…Such growth was not significant in Mg/FHA, compared to the Mg/FHA/Ta group. In Mg/FHA group, the brushite (CaHPO 4 .2H 2 O) diffraction peak was not stable, which indicated that the crystallinity and coating thickness were not sufficient to be detected ( Zhao et al, 2016 ; Noumbissi et al, 2019 ; Wang et al, 2020 ). This result corresponded with previous studies which found that insufficient coating thickness and crystallinity significantly influenced the XRD detection ( Bir et al, 2015 ).…”

Section: Resultsmentioning

confidence: 98%

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Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Cao

Yang

et al. 2021

Front. Chem.

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Magnesium (Mg) alloys have a wide range of biomaterial applications, but their lack of biocompatibility and osteoinduction property impedes osteointegration. In order to enhance the bioactivity of Mg alloy, a composite coating of fluorinated hydroxyapatite (FHA) and tantalum (Ta) was first developed on the surface of the alloy through thermal synthesis and magnetron sputtering technologies in this study. The samples were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive spectroscopy (EDS) mapping, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and water contact angle measurement (WCA), which characterized the surface alternation and confirmed the deposition of the target FHA/Ta coating. The results of cell morphology showed that the MC3T3-E1 cells on the surface of Mg/FHA/Ta samples had the largest spreading area and lamellipodia. Moreover, the FHA coating endowed the surface with superior cell viability and osteogenic properties, while Ta coating played a more important role in osteogenic differentiation. Therefore, the combination of FHA and Ta coatings could synergistically promote biological functions, thus providing a novel strategy for implant design.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 98%

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Cao

Yang

et al. 2021

Front. Chem.

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“… 54 Together with CCK-8 and ALP assay, evidences showed the enhancement of osteogenic activity, consistent with the results of Wang et al and Stan et al, comparing TNNs and TNTs with original surface in terms of osteogenesis, respectively. 38 , 55 Besides, our study also indicated stronger osteogenesis on TNT substrates than TNN substrates.…”

Section: Discussionsupporting

confidence: 63%

“…36,37 Wang et al reported that SrTiO 3 nanolayer coating on alkaliheat treated titanium possessed osteointegration promotion ability and long-term ion release capacity. 38 As the nano-topographies with the property for further functionalization, the basic ability of TNTs and TNNs for osteogenesis has also been studied. 39,40 However, some limits still exist among previous investigations.…”

Section: Introductionmentioning

confidence: 99%

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Different Cell and Tissue Behavior of Micro-/Nano-Tubes and Micro-/Nano-Nets Topographies on Selective Laser Melting Titanium to Enhance Osseointegration

Yu¹,

Xu²,

Zhang³

et al. 2021

IJN

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Background and Purpose: Micro-/nano-tubes (TNTs) and micro-/nano-nets (TNNs) are the common and sensible choice in the first step of combined modifications of titanium surface for further functionalization in the purpose of extended indications and therapeutic effect. It is important to recognize the respective biologic reactions of these two substrates for guiding a biologically based first-step selection. Materials and Methods: TNTs were produced by anodic oxidation and TNNs were formed by alkali-heat treatment. The original selective laser melting (SLM) titanium surface was set as control. Surface characterization was evaluated by scanning electron microscopy, surface roughness, and water contact angle measurements. Osteoclastogenesis and osteogenesis were measured. MC3T3-E1 cells and RAW 264.7 cells were used for in vitro assay in terms of adhesion, proliferation, and differentiation. In vivo assessments were taken on Beagle dogs with micro-CT and histological analysis. Results: TNN and TNT groups performed decreased roughness and increased hydrophilicity compared with SLM group. For biological detections, the highest ALP activity and osteogenesis-related genes expression were observed in TNT group followed by TNN group (P <0.05). Interestingly, when it comes to the osteoclastogenesis, TNNs displayed lowest TRAP activity and osteoclastogenesis-related genes expression and TNTs were lower than SLM but higher than TNNs (P <0.05). BV/TV around implants was highest in TNT group after 4 weeks (P <0.05). HE, ALP and TRAP staining showed that osteogenic and osteoclastic activity around TNTs were both higher than TNNs (P <0.05). Conclusion:TNNs and TNTs have dual advantages in promotion of osteogenesis and inhibition of osteoclastogenesis. Furthermore, TNNs showed better capability in inhibiting osteoclast activity while TNTs facilitated stronger osteogenesis. Our results implied that TNT substrates would take advantage in early application after implantation, while diseases with inappropriate osteoclast activity would prefer TNN substrates, which will guide a biologically based first-step selection on combined modification for different clinical purposes.

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A Multifunctional Metal–Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation

Liu,

Shi,

Zhao

et al. 2024

Advanced Science

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Surface modification is an important approach to improve osseointegration of the endosseous implants, however it is still desirable to develop a facile yet efficient coating strategy. Herein, a metal–phenolic network (MPN) is proposed as a multifunctional nanocoating on titanium (Ti) implants for enhanced osseointegration through early immunomodulation. With tannic acid (TA) and Sr2+ self‐assembled on Ti substrates, the MPN coatings provided a bioactive interface, which can facilitate the initial adhesion and recruitment of bone marrow mesenchymal stem cells (BMSCs) and polarize macrophage toward M2 phenotype. Furthermore, the TA‐Sr coatings accelerated the osteogenic differentiation of BMSCs. In vivo evaluations further confirmed the enhanced osseointegration of TA‐Sr modified implants via generating a favorable osteoimmune microenvironment. In general, these results suggest that TA‐Sr MPN nanocoating is a promising strategy for achieving better and faster osseointegration of bone implants, which can be easily utilized in future clinical applications.

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<p>The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant</p>

Cited by 23 publications

References 61 publications

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Different Cell and Tissue Behavior of Micro-/Nano-Tubes and Micro-/Nano-Nets Topographies on Selective Laser Melting Titanium to Enhance Osseointegration

A Multifunctional Metal–Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation

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