&lt;p&gt;The Effects of Gold Nanoparticles on Leydig Cells and Male Reproductive Function in Mice&lt;/p&gt;

Liu, Ying; Li, Xiaojie; Xiao, Shuwen; Liu, Xinyi; Chen, Xuanming; Xia, Qing; Song, Lei; Zhong, Zhihui; Xiao, Kai

doi:10.2147/ijn.s276606

Cited by 29 publications

(15 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The potential adverse effect of AuNPs on the reproductive system has been investigated by histological observations and assessment of AuNP accumulation in male or female reproductive organs, evaluation of the sperm quality and fertility of males, as well as the quantification of the sex hormones in the serum of the blood. More specifically, AuNPs can accumulate in the testes and cause the reduction of testosterone production through the downregulation of the expression of 17α-hydroxylase [125,126].…”

Section: Genotoxicity and Mutagenicitymentioning

confidence: 99%

Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations

Kus‐Liśkiewicz

Fickers

Tahar

2021

IJMS

105

View full text Add to dashboard Cite

Recent advances in the synthesis of metal nanoparticles (MeNPs), and more specifically gold nanoparticles (AuNPs), have led to tremendous expansion of their potential applications in different fields, ranging from healthcare research to microelectronics and food packaging. The properties of functionalised MeNPs can be fine-tuned depending on their final application, and subsequently, these properties can strongly modulate their biological effects. In this review, we will firstly focus on the impact of MeNP characteristics (particularly of gold nanoparticles, AuNPs) such as shape, size, and aggregation on their biological activities. Moreover, we will detail different in vitro and in vivo assays to be performed when cytotoxicity and biocompatibility must be assessed. Due to the complex nature of nanomaterials, conflicting studies have led to different views on their safety, and it is clear that the definition of a standard biosafety label for AuNPs is difficult. In fact, AuNPs’ biocompatibility is strongly affected by the nanoparticles’ intrinsic characteristics, biological target, and methodology employed to evaluate their toxicity. In the last part of this review, the current legislation and requirements established by regulatory authorities, defining the main guidelines and standards to characterise new nanomaterials, will also be discussed, as this aspect has not been reviewed recently. It is clear that the lack of well-established safety regulations based on reliable, robust, and universal methodologies has hampered the development of MeNP applications in the healthcare field. Henceforth, the international community must make an effort to adopt specific and standard protocols for characterisation of these products.

show abstract

Section: Genotoxicity and Mutagenicitymentioning

confidence: 99%

Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations

Kus‐Liśkiewicz

Fickers

Tahar

2021

IJMS

105

View full text Add to dashboard Cite

show abstract

“…Most metal or metal oxide NMs smaller than 100 nm can cross the Sertoli cell barrier; however, the other properties of the nanomaterials are also important to their behavior. For example, gold nanoparticles (AuNPs), silver nanoparticles (AgNPs), carbon nanotubes, nano-silica (SiO 2 NPs), Zinc oxide nanoparticles (ZnO NPs), and cerium oxide nanoparticles (CeO 2 NPs) all can enter the testes, while Au, Ag, titanium oxide (TiO 2 NPs), and CeO 2 NPs tend to accumulate in the testes (Ge et al, 2012;Li et al, 2012Liu, Li, et al, 2020;Lu et al, 2019;Meena et al, 2015;Morishita et al, 2012;Qin et al, 2019;Zande et al, 2012). Unlike the blood-brain barrier, no pathway has been shown to bypass the Sertoli cell barrier in order for entry into the seminiferous tubules.…”

Section: Testicular Injurymentioning

confidence: 99%

The potential for nanomaterial toxicity affecting the male reproductive system

Ning

Zhang

et al. 2022

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

With the development of nanotechnology, nanomaterials offer great advantages in a wide variety of industrial and consumer products, and show promise for biomedical applications. However, with these new products, nanomaterial pollutants may enter the human body to cause adverse health effects, including hazards to the male reproductive system. Nanomaterials can enter the body through inhalation, oral exposure, or intravenous injection, and reach the testis via the blood, penetrate the Sertoli cell barrier, and directly or indirectly elicit toxicopathological changes to the testicles. These may then trigger hormone disorders, inhibit spermatogenic cell proliferation, and induce apoptosis, ultimately leading to a decrease in sperm motility and number, ultimately diminishing male reproductive capacity. This review will discuss the toxicological effects of nanomaterials on the male reproductive system, including inflammation, the impact on the hypothalamic–pituitary–gonadal axis (HPG axis), lipid peroxidation, and free ion release relevant to germ cells, Sertoli cell tight junctions, and the gonadal endocrine system.This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

show abstract

“…The integrity of BTB is a concern since NPs can easily permeate cells and their nuclei. This creates favorable circumstances for mutations appearance, which in germ cells may interfere with fertilization, embryogenesis [100], or even generate congenital defects in the offspring [101]. Spermatogenesis is initiated at puberty by the hypothalamus, which produces GnRH, which, in turn, stimulates the release of FSH and LH at the reproductive tract.…”

Section: The Impact Of Monps On Male Fertilitymentioning

confidence: 99%

Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System

Vassal

Rebelo

Pereira

2021

IJMS

View full text Add to dashboard Cite

Metal oxide nanoparticles (MONPs) are inorganic materials that have become a valuable tool for many industrial sectors, especially in healthcare, due to their versatility, unique intrinsic properties, and relatively inexpensive production cost. As a consequence of their wide applications, human exposure to MONPs has increased dramatically. More recently, their use has become somehow controversial. On one hand, MONPs can interact with cellular macromolecules, which makes them useful platforms for diagnostic and therapeutic interventions. On the other hand, research suggests that these MONPs can cross the blood–testis barrier and accumulate in the testis. Although it has been demonstrated that some MONPs have protective effects on male germ cells, contradictory reports suggest that these nanoparticles compromise male fertility by interfering with spermatogenesis. In fact, in vitro and in vivo studies indicate that exposure to MONPs could induce the overproduction of reactive oxygen species, resulting in oxidative stress, which is the main suggested molecular mechanism that leads to germ cells’ toxicity. The latter results in subsequent damage to proteins, cell membranes, and DNA, which ultimately may lead to the impairment of the male reproductive system. The present manuscript overviews the therapeutic potential of MONPs and their biomedical applications, followed by a critical view of their potential risks in mammalian male fertility, as suggested by recent scientific literature.

show abstract

<p>The Effects of Gold Nanoparticles on Leydig Cells and Male Reproductive Function in Mice</p>

Cited by 29 publications

References 54 publications

Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations

Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations

The potential for nanomaterial toxicity affecting the male reproductive system

Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System

Contact Info

Product

Resources

About