<p>The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial</p>

Abstract

Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular homeostasis. Molecular hydrogen (H 2) may attenuate oxidative stress, improve cellular function, and reduce chronic inflammation. Preclinical and clinical studies have shown promising effects of H 2-rich water (HRW) on specific features of metabolic syndrome, yet the effects of long-term, high-concentration HRW in this prevalent condition remain poorly addressed. Methods: We conducted a randomized, double-blinded, placebo-controlled trial in 60 subjects (30 men and 30 women) with metabolic syndrome. An initial observation period of one week was used to acquire baseline clinical data followed by randomization to either placebo or high-concentration HRW (> 5.5 millimoles of H 2 per day) for 24 weeks. Results: Supplementation with high-concentration HRW significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis as compared to placebo (P < 0.05). Furthermore, H 2 tended to promote a mild reduction in body mass index and waist-to-hip ratio. Conclusion: Our results give further credence that high-concentration HRW might have promising effects as a therapeutic modality for attenuating risk factors of metabolic syndrome.

Synergistic Effects of Regular Walking and Alkaline Electrolyzed Water on Decreasing Inflammation and Oxidative Stress, and Increasing Quality of Life in Individuals with Type 2 Diabetes: A Community Based Randomized Controlled Trial

“…AEW is also used as a therapeutic substance, and was reported to reduce insulin resistance (IR) in animal models [ 19 , 20 ]. However, few studies have explored the antidiabetic effects of AEW in humans [ 21 , 22 , 23 , 24 , 25 , 26 ]. AEW was revealed to ameliorate blood glucose, MDA, interleukin-6 and tumor necrosis factor alpha [ 25 ], and to increase the oxidant potential [ 26 ].…”

“…However, few studies have explored the antidiabetic effects of AEW in humans [ 21 , 22 , 23 , 24 , 25 , 26 ]. AEW was revealed to ameliorate blood glucose, MDA, interleukin-6 and tumor necrosis factor alpha [ 25 ], and to increase the oxidant potential [ 26 ]. A study by Gadek et al [ 27 ] showed that patients who drank at least 2 L/day of AEW had significantly decreased blood glucose and glycated hemoglobin levels after treatment for 6 days.…”

Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity Mice

“…Moreover, in a human study, a hydrogen-rich water bath once daily for 6 months was reported to decrease visceral fat with reductions in low-density lipoprotein and fasting blood glucose levels [ 11 ]. Clinically, MH intake was reported to be effective against metabolic syndrome (MetS) [ 12 ] and the adverse effects of chemotherapy [ 13 ] and radiotherapy [ 14 ].…”

Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems

“…Molecular hydrogen is currently recognized as an emerging therapeutic, as its supplemental application exerts protective effects in cardiovascular diseases [ 1 , 2 ], neurodegenerative diseases [ 3 ], inflammatory diseases [ 4 ], neuromuscular disorders [ 5 ], metabolic syndrome [ 6 ] diabetes [ 7 , 8 ], kidney disorders [ 9 , 10 ], and cancer [ 11 ]. The protective effects of molecular hydrogen are largely related to its antiapoptotic, anti-inflammatory, and antioxidative actions ( Figure 1 ).…”

“…They found that inhalation of 1.3% H 2 during PCI resulted in left ventricular (LV) reverse remodeling at six months after STEMI. The positive effects of H 2 were also demonstrated in metabolic syndrome ( n = 60) using a double-blinded, placebo-controlled trial [ 6 ]. The consumption of H 2 -rich water for 24 weeks led to a significant reduction in blood cholesterol, glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis as compared to the placebo group.…”